Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices

Abstract The contact cardiac electrogram is derived from the extracellular manifestation of cellular action potentials and cell-to-cell communication. It is used to guide catheter based clinical procedures. Theoretically, the contact electrogram and the cellular action potential are directly related...

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Autores principales:	Rasheda A. Chowdhury, Konstantinos N. Tzortzis, Emmanuel Dupont, Shaun Selvadurai, Filippo Perbellini, Chris D. Cantwell, Fu Siong Ng, Andre R. Simon, Cesare M. Terracciano, Nicholas S. Peters
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f3def2e7326c4f699b77217db0871ad1
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spelling	oai:doaj.org-article:f3def2e7326c4f699b77217db0871ad12021-12-02T16:07:51ZConcurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices10.1038/s41598-018-25170-92045-2322https://doaj.org/article/f3def2e7326c4f699b77217db0871ad12018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25170-9https://doaj.org/toc/2045-2322Abstract The contact cardiac electrogram is derived from the extracellular manifestation of cellular action potentials and cell-to-cell communication. It is used to guide catheter based clinical procedures. Theoretically, the contact electrogram and the cellular action potential are directly related, and should change in conjunction with each other during arrhythmogenesis, however there is currently no methodology by which to concurrently record both electrograms and action potentials in the same preparation for direct validation of their relationships and their direct mechanistic links. We report a novel dual modality apparatus for concurrent electrogram and cellular action potential recording at a single cell level within multicellular preparations. We further demonstrate the capabilities of this system to validate the direct link between these two modalities of voltage recordings.Rasheda A. ChowdhuryKonstantinos N. TzortzisEmmanuel DupontShaun SelvaduraiFilippo PerbelliniChris D. CantwellFu Siong NgAndre R. SimonCesare M. TerraccianoNicholas S. PetersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rasheda A. Chowdhury Konstantinos N. Tzortzis Emmanuel Dupont Shaun Selvadurai Filippo Perbellini Chris D. Cantwell Fu Siong Ng Andre R. Simon Cesare M. Terracciano Nicholas S. Peters Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices
description	Abstract The contact cardiac electrogram is derived from the extracellular manifestation of cellular action potentials and cell-to-cell communication. It is used to guide catheter based clinical procedures. Theoretically, the contact electrogram and the cellular action potential are directly related, and should change in conjunction with each other during arrhythmogenesis, however there is currently no methodology by which to concurrently record both electrograms and action potentials in the same preparation for direct validation of their relationships and their direct mechanistic links. We report a novel dual modality apparatus for concurrent electrogram and cellular action potential recording at a single cell level within multicellular preparations. We further demonstrate the capabilities of this system to validate the direct link between these two modalities of voltage recordings.
format	article
author	Rasheda A. Chowdhury Konstantinos N. Tzortzis Emmanuel Dupont Shaun Selvadurai Filippo Perbellini Chris D. Cantwell Fu Siong Ng Andre R. Simon Cesare M. Terracciano Nicholas S. Peters
author_facet	Rasheda A. Chowdhury Konstantinos N. Tzortzis Emmanuel Dupont Shaun Selvadurai Filippo Perbellini Chris D. Cantwell Fu Siong Ng Andre R. Simon Cesare M. Terracciano Nicholas S. Peters
author_sort	Rasheda A. Chowdhury
title	Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices
title_short	Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices
title_full	Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices
title_fullStr	Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices
title_full_unstemmed	Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices
title_sort	concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f3def2e7326c4f699b77217db0871ad1
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Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices

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