Possible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide

Currently, the clinical impact of cell therapy after a myocardial infarction (MI) is limited by low cell engraftment due to low cell retention, cell death in inflammatory and poor angiogenic infarcted areas, secondary migration. Cells interact with their microenvironment through integrin mechanorece...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Olivier Schussler, Pierre E. Falcoz, Juan C. Chachques, Marco Alifano, Yves Lecarpentier
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	RGD adhesion molecules contractility collagen tissue engineering myocardial infarct Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f3e380544d494238aea9edffa4075c67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f3e380544d494238aea9edffa4075c67
record_format	dspace
spelling	oai:doaj.org-article:f3e380544d494238aea9edffa4075c672021-11-25T17:57:56ZPossible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide10.3390/ijms2222125631422-00671661-6596https://doaj.org/article/f3e380544d494238aea9edffa4075c672021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12563https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Currently, the clinical impact of cell therapy after a myocardial infarction (MI) is limited by low cell engraftment due to low cell retention, cell death in inflammatory and poor angiogenic infarcted areas, secondary migration. Cells interact with their microenvironment through integrin mechanoreceptors that control their survival/apoptosis/differentiation/migration and proliferation. The association of cells with a three-dimensional material may be a way to improve interactions with their integrins, and thus outcomes, especially if preparations are epicardially applied. In this review, we will focus on the rationale for using collagen as a polymer backbone for tissue engineering of a contractile tissue. Contractilities are reported for natural but not synthetic polymers and for naturals only for: collagen/gelatin/decellularized-tissue/fibrin/Matrigel™ and for different material states: hydrogels/gels/solids. To achieve a thick/long-term contractile tissue and for cell transfer, solid porous compliant scaffolds are superior to hydrogels or gels. Classical methods to produce solid scaffolds: electrospinning/freeze-drying/3D-printing/solvent-casting and methods to reinforce and/or maintain scaffold properties by reticulations are reported. We also highlight the possibility of improving integrin interaction between cells and their associated collagen by its functionalizing with the RGD-peptide. Using a contractile patch that can be applied epicardially may be a way of improving ventricular remodeling and limiting secondary cell migration.Olivier SchusslerPierre E. FalcozJuan C. ChachquesMarco AlifanoYves LecarpentierMDPI AGarticleRGDadhesion moleculescontractilitycollagentissue engineeringmyocardial infarctBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12563, p 12563 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RGD adhesion molecules contractility collagen tissue engineering myocardial infarct Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	RGD adhesion molecules contractility collagen tissue engineering myocardial infarct Biology (General) QH301-705.5 Chemistry QD1-999 Olivier Schussler Pierre E. Falcoz Juan C. Chachques Marco Alifano Yves Lecarpentier Possible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide
description	Currently, the clinical impact of cell therapy after a myocardial infarction (MI) is limited by low cell engraftment due to low cell retention, cell death in inflammatory and poor angiogenic infarcted areas, secondary migration. Cells interact with their microenvironment through integrin mechanoreceptors that control their survival/apoptosis/differentiation/migration and proliferation. The association of cells with a three-dimensional material may be a way to improve interactions with their integrins, and thus outcomes, especially if preparations are epicardially applied. In this review, we will focus on the rationale for using collagen as a polymer backbone for tissue engineering of a contractile tissue. Contractilities are reported for natural but not synthetic polymers and for naturals only for: collagen/gelatin/decellularized-tissue/fibrin/Matrigel™ and for different material states: hydrogels/gels/solids. To achieve a thick/long-term contractile tissue and for cell transfer, solid porous compliant scaffolds are superior to hydrogels or gels. Classical methods to produce solid scaffolds: electrospinning/freeze-drying/3D-printing/solvent-casting and methods to reinforce and/or maintain scaffold properties by reticulations are reported. We also highlight the possibility of improving integrin interaction between cells and their associated collagen by its functionalizing with the RGD-peptide. Using a contractile patch that can be applied epicardially may be a way of improving ventricular remodeling and limiting secondary cell migration.
format	article
author	Olivier Schussler Pierre E. Falcoz Juan C. Chachques Marco Alifano Yves Lecarpentier
author_facet	Olivier Schussler Pierre E. Falcoz Juan C. Chachques Marco Alifano Yves Lecarpentier
author_sort	Olivier Schussler
title	Possible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide
title_short	Possible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide
title_full	Possible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide
title_fullStr	Possible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide
title_full_unstemmed	Possible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide
title_sort	possible treatment of myocardial infarct based on tissue engineering using a cellularized solid collagen scaffold functionalized with arg-glyc-asp (rgd) peptide
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f3e380544d494238aea9edffa4075c67
work_keys_str_mv	AT olivierschussler possibletreatmentofmyocardialinfarctbasedontissueengineeringusingacellularizedsolidcollagenscaffoldfunctionalizedwithargglycasprgdpeptide AT pierreefalcoz possibletreatmentofmyocardialinfarctbasedontissueengineeringusingacellularizedsolidcollagenscaffoldfunctionalizedwithargglycasprgdpeptide AT juancchachques possibletreatmentofmyocardialinfarctbasedontissueengineeringusingacellularizedsolidcollagenscaffoldfunctionalizedwithargglycasprgdpeptide AT marcoalifano possibletreatmentofmyocardialinfarctbasedontissueengineeringusingacellularizedsolidcollagenscaffoldfunctionalizedwithargglycasprgdpeptide AT yveslecarpentier possibletreatmentofmyocardialinfarctbasedontissueengineeringusingacellularizedsolidcollagenscaffoldfunctionalizedwithargglycasprgdpeptide
_version_	1718411839615795200

Possible Treatment of Myocardial Infarct Based on Tissue Engineering Using a Cellularized Solid Collagen Scaffold Functionalized with Arg-Glyc-Asp (RGD) Peptide

Ejemplares similares