Iron and Neurodevelopment in Preterm Infants: A Narrative Review

Iron is critical for brain development, playing key roles in synaptogenesis, myelination, energy metabolism and neurotransmitter production. NICU infants are at particular risk for iron deficiency due to high iron needs, preterm birth, disruptions in maternal or placental health and phlebotomy. If d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kendell R. German, Sandra E. Juul
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	iron neurodevelopment brain development Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/f3ecb003d09348688202db2136190fde
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f3ecb003d09348688202db2136190fde
record_format	dspace
spelling	oai:doaj.org-article:f3ecb003d09348688202db2136190fde2021-11-25T18:33:37ZIron and Neurodevelopment in Preterm Infants: A Narrative Review10.3390/nu131137372072-6643https://doaj.org/article/f3ecb003d09348688202db2136190fde2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3737https://doaj.org/toc/2072-6643Iron is critical for brain development, playing key roles in synaptogenesis, myelination, energy metabolism and neurotransmitter production. NICU infants are at particular risk for iron deficiency due to high iron needs, preterm birth, disruptions in maternal or placental health and phlebotomy. If deficiency occurs during critical periods of brain development, this may lead to permanent alterations in brain structure and function which is not reversible despite later supplementation. Children with perinatal iron deficiency have been shown to have delayed nerve conduction speeds, disrupted sleep patterns, impaired recognition memory, motor deficits and lower global developmental scores which may be present as early as in the neonatal period and persist into adulthood. Based on this, ensuring brain iron sufficiency during the neonatal period is critical to optimizing neurodevelopmental outcomes and iron supplementation should be targeted to iron measures that correlate with improved outcomes.Kendell R. GermanSandra E. JuulMDPI AGarticleironneurodevelopmentbrain developmentNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3737, p 3737 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	iron neurodevelopment brain development Nutrition. Foods and food supply TX341-641
spellingShingle	iron neurodevelopment brain development Nutrition. Foods and food supply TX341-641 Kendell R. German Sandra E. Juul Iron and Neurodevelopment in Preterm Infants: A Narrative Review
description	Iron is critical for brain development, playing key roles in synaptogenesis, myelination, energy metabolism and neurotransmitter production. NICU infants are at particular risk for iron deficiency due to high iron needs, preterm birth, disruptions in maternal or placental health and phlebotomy. If deficiency occurs during critical periods of brain development, this may lead to permanent alterations in brain structure and function which is not reversible despite later supplementation. Children with perinatal iron deficiency have been shown to have delayed nerve conduction speeds, disrupted sleep patterns, impaired recognition memory, motor deficits and lower global developmental scores which may be present as early as in the neonatal period and persist into adulthood. Based on this, ensuring brain iron sufficiency during the neonatal period is critical to optimizing neurodevelopmental outcomes and iron supplementation should be targeted to iron measures that correlate with improved outcomes.
format	article
author	Kendell R. German Sandra E. Juul
author_facet	Kendell R. German Sandra E. Juul
author_sort	Kendell R. German
title	Iron and Neurodevelopment in Preterm Infants: A Narrative Review
title_short	Iron and Neurodevelopment in Preterm Infants: A Narrative Review
title_full	Iron and Neurodevelopment in Preterm Infants: A Narrative Review
title_fullStr	Iron and Neurodevelopment in Preterm Infants: A Narrative Review
title_full_unstemmed	Iron and Neurodevelopment in Preterm Infants: A Narrative Review
title_sort	iron and neurodevelopment in preterm infants: a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f3ecb003d09348688202db2136190fde
work_keys_str_mv	AT kendellrgerman ironandneurodevelopmentinpreterminfantsanarrativereview AT sandraejuul ironandneurodevelopmentinpreterminfantsanarrativereview
_version_	1718410988816957440

Iron and Neurodevelopment in Preterm Infants: A Narrative Review

Ejemplares similares