Ultraviolet light-induced collagen degradation inhibits melanoma invasion

Ultraviolet radiation (UVR) increases melanoma incidence. Here, the authors report that UVR-damaged dermal fibroblasts upregulate MMP1 to degrade collagen which inhibits melanoma invasion and that aged primary melanomas in skin with degraded collagen have a better prognosis, while new collagen synth...

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Autores principales:	Timothy Budden, Caroline Gaudy-Marqueste, Andrew Porter, Emily Kay, Shilpa Gurung, Charles H. Earnshaw, Katharina Roeck, Sarah Craig, Víctor Traves, Jean Krutmann, Patricia Muller, Luisa Motta, Sara Zanivan, Angeliki Malliri, Simon J. Furney, Eduardo Nagore, Amaya Virós
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3eebf3f892a42e28f17cc0ebdce6bf8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:f3eebf3f892a42e28f17cc0ebdce6bf82021-12-02T17:15:32ZUltraviolet light-induced collagen degradation inhibits melanoma invasion10.1038/s41467-021-22953-z2041-1723https://doaj.org/article/f3eebf3f892a42e28f17cc0ebdce6bf82021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22953-zhttps://doaj.org/toc/2041-1723Ultraviolet radiation (UVR) increases melanoma incidence. Here, the authors report that UVR-damaged dermal fibroblasts upregulate MMP1 to degrade collagen which inhibits melanoma invasion and that aged primary melanomas in skin with degraded collagen have a better prognosis, while new collagen synthesis restores invasion and leads to death.Timothy BuddenCaroline Gaudy-MarquesteAndrew PorterEmily KayShilpa GurungCharles H. EarnshawKatharina RoeckSarah CraigVíctor TravesJean KrutmannPatricia MullerLuisa MottaSara ZanivanAngeliki MalliriSimon J. FurneyEduardo NagoreAmaya VirósNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Timothy Budden Caroline Gaudy-Marqueste Andrew Porter Emily Kay Shilpa Gurung Charles H. Earnshaw Katharina Roeck Sarah Craig Víctor Traves Jean Krutmann Patricia Muller Luisa Motta Sara Zanivan Angeliki Malliri Simon J. Furney Eduardo Nagore Amaya Virós Ultraviolet light-induced collagen degradation inhibits melanoma invasion
description	Ultraviolet radiation (UVR) increases melanoma incidence. Here, the authors report that UVR-damaged dermal fibroblasts upregulate MMP1 to degrade collagen which inhibits melanoma invasion and that aged primary melanomas in skin with degraded collagen have a better prognosis, while new collagen synthesis restores invasion and leads to death.
format	article
author	Timothy Budden Caroline Gaudy-Marqueste Andrew Porter Emily Kay Shilpa Gurung Charles H. Earnshaw Katharina Roeck Sarah Craig Víctor Traves Jean Krutmann Patricia Muller Luisa Motta Sara Zanivan Angeliki Malliri Simon J. Furney Eduardo Nagore Amaya Virós
author_facet	Timothy Budden Caroline Gaudy-Marqueste Andrew Porter Emily Kay Shilpa Gurung Charles H. Earnshaw Katharina Roeck Sarah Craig Víctor Traves Jean Krutmann Patricia Muller Luisa Motta Sara Zanivan Angeliki Malliri Simon J. Furney Eduardo Nagore Amaya Virós
author_sort	Timothy Budden
title	Ultraviolet light-induced collagen degradation inhibits melanoma invasion
title_short	Ultraviolet light-induced collagen degradation inhibits melanoma invasion
title_full	Ultraviolet light-induced collagen degradation inhibits melanoma invasion
title_fullStr	Ultraviolet light-induced collagen degradation inhibits melanoma invasion
title_full_unstemmed	Ultraviolet light-induced collagen degradation inhibits melanoma invasion
title_sort	ultraviolet light-induced collagen degradation inhibits melanoma invasion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3eebf3f892a42e28f17cc0ebdce6bf8
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Ultraviolet light-induced collagen degradation inhibits melanoma invasion

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