Role of mutational reversions and fitness restoration in Zika virus spread to the Americas

The trajectory of the emergence of Zika virus (ZIKV) into the Americas remains unclear. Here, the authors find that four mutations originated before ZIKV introduction to the Americas are direct reversions of previous mutations that accompanied spread many decades ago from ZIKV’s native Africa to Asi...

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Autores principales:	Jianying Liu, Yang Liu, Chao Shan, Bruno T. D. Nunes, Ruimei Yun, Sherry L. Haller, Grace H. Rafael, Sasha R. Azar, Clark R. Andersen, Kenneth Plante, Nikos Vasilakis, Pei-Yong Shi, Scott C. Weaver
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3efba102a884e04b70d3b7ef247c0bf
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spelling	oai:doaj.org-article:f3efba102a884e04b70d3b7ef247c0bf2021-12-02T13:24:33ZRole of mutational reversions and fitness restoration in Zika virus spread to the Americas10.1038/s41467-020-20747-32041-1723https://doaj.org/article/f3efba102a884e04b70d3b7ef247c0bf2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20747-3https://doaj.org/toc/2041-1723The trajectory of the emergence of Zika virus (ZIKV) into the Americas remains unclear. Here, the authors find that four mutations originated before ZIKV introduction to the Americas are direct reversions of previous mutations that accompanied spread many decades ago from ZIKV’s native Africa to Asia, and show in experimental infections of mosquitoes, human cells, and mice that the original mutations reduced fitness for urban transmission, while the reversions restored fitness, likely increasing epidemic risk.Jianying LiuYang LiuChao ShanBruno T. D. NunesRuimei YunSherry L. HallerGrace H. RafaelSasha R. AzarClark R. AndersenKenneth PlanteNikos VasilakisPei-Yong ShiScott C. WeaverNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jianying Liu Yang Liu Chao Shan Bruno T. D. Nunes Ruimei Yun Sherry L. Haller Grace H. Rafael Sasha R. Azar Clark R. Andersen Kenneth Plante Nikos Vasilakis Pei-Yong Shi Scott C. Weaver Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
description	The trajectory of the emergence of Zika virus (ZIKV) into the Americas remains unclear. Here, the authors find that four mutations originated before ZIKV introduction to the Americas are direct reversions of previous mutations that accompanied spread many decades ago from ZIKV’s native Africa to Asia, and show in experimental infections of mosquitoes, human cells, and mice that the original mutations reduced fitness for urban transmission, while the reversions restored fitness, likely increasing epidemic risk.
format	article
author	Jianying Liu Yang Liu Chao Shan Bruno T. D. Nunes Ruimei Yun Sherry L. Haller Grace H. Rafael Sasha R. Azar Clark R. Andersen Kenneth Plante Nikos Vasilakis Pei-Yong Shi Scott C. Weaver
author_facet	Jianying Liu Yang Liu Chao Shan Bruno T. D. Nunes Ruimei Yun Sherry L. Haller Grace H. Rafael Sasha R. Azar Clark R. Andersen Kenneth Plante Nikos Vasilakis Pei-Yong Shi Scott C. Weaver
author_sort	Jianying Liu
title	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_short	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_full	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_fullStr	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_full_unstemmed	Role of mutational reversions and fitness restoration in Zika virus spread to the Americas
title_sort	role of mutational reversions and fitness restoration in zika virus spread to the americas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f3efba102a884e04b70d3b7ef247c0bf
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Role of mutational reversions and fitness restoration in Zika virus spread to the Americas

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