Surface protein imputation from single cell transcriptomes by deep neural networks

Cell-surface proteins serve as phenotypic cell markers and in many cases are more indicative of cellular function than the transcriptome. Here, the authors introduce a transfer learning framework to impute surface protein abundances from scRNA-seq data.

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Detalles Bibliográficos
Autores principales:	Zilu Zhou, Chengzhong Ye, Jingshu Wang, Nancy R. Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3f0dd0683dd476f946e529ea4212892
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id	oai:doaj.org-article:f3f0dd0683dd476f946e529ea4212892
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spelling	oai:doaj.org-article:f3f0dd0683dd476f946e529ea42128922021-12-02T14:41:01ZSurface protein imputation from single cell transcriptomes by deep neural networks10.1038/s41467-020-14391-02041-1723https://doaj.org/article/f3f0dd0683dd476f946e529ea42128922020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14391-0https://doaj.org/toc/2041-1723Cell-surface proteins serve as phenotypic cell markers and in many cases are more indicative of cellular function than the transcriptome. Here, the authors introduce a transfer learning framework to impute surface protein abundances from scRNA-seq data.Zilu ZhouChengzhong YeJingshu WangNancy R. ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zilu Zhou Chengzhong Ye Jingshu Wang Nancy R. Zhang Surface protein imputation from single cell transcriptomes by deep neural networks
description	Cell-surface proteins serve as phenotypic cell markers and in many cases are more indicative of cellular function than the transcriptome. Here, the authors introduce a transfer learning framework to impute surface protein abundances from scRNA-seq data.
format	article
author	Zilu Zhou Chengzhong Ye Jingshu Wang Nancy R. Zhang
author_facet	Zilu Zhou Chengzhong Ye Jingshu Wang Nancy R. Zhang
author_sort	Zilu Zhou
title	Surface protein imputation from single cell transcriptomes by deep neural networks
title_short	Surface protein imputation from single cell transcriptomes by deep neural networks
title_full	Surface protein imputation from single cell transcriptomes by deep neural networks
title_fullStr	Surface protein imputation from single cell transcriptomes by deep neural networks
title_full_unstemmed	Surface protein imputation from single cell transcriptomes by deep neural networks
title_sort	surface protein imputation from single cell transcriptomes by deep neural networks
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f3f0dd0683dd476f946e529ea4212892
work_keys_str_mv	AT ziluzhou surfaceproteinimputationfromsinglecelltranscriptomesbydeepneuralnetworks AT chengzhongye surfaceproteinimputationfromsinglecelltranscriptomesbydeepneuralnetworks AT jingshuwang surfaceproteinimputationfromsinglecelltranscriptomesbydeepneuralnetworks AT nancyrzhang surfaceproteinimputationfromsinglecelltranscriptomesbydeepneuralnetworks
_version_	1718390090455056384

Surface protein imputation from single cell transcriptomes by deep neural networks

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