Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking

The actomyosin cytoskeleton plays an important role in polarised cell migration. Here the authors identify lymphocyte-specific protein (LSP)-1 as a regulator of actomyosin contractility in macrophages, by competing with supervillin for myosin IIA activators acting specifically on the β-actin isoform...

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Autores principales:	Pasquale Cervero, Christiane Wiesner, Anais Bouissou, Renaud Poincloux, Stefan Linder
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f3f5c58257864c0498c0aecf08fa9c52
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spelling	oai:doaj.org-article:f3f5c58257864c0498c0aecf08fa9c522021-12-02T17:31:16ZLymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking10.1038/s41467-018-02904-x2041-1723https://doaj.org/article/f3f5c58257864c0498c0aecf08fa9c522018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02904-xhttps://doaj.org/toc/2041-1723The actomyosin cytoskeleton plays an important role in polarised cell migration. Here the authors identify lymphocyte-specific protein (LSP)-1 as a regulator of actomyosin contractility in macrophages, by competing with supervillin for myosin IIA activators acting specifically on the β-actin isoform.Pasquale CerveroChristiane WiesnerAnais BouissouRenaud PoinclouxStefan LinderNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pasquale Cervero Christiane Wiesner Anais Bouissou Renaud Poincloux Stefan Linder Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking
description	The actomyosin cytoskeleton plays an important role in polarised cell migration. Here the authors identify lymphocyte-specific protein (LSP)-1 as a regulator of actomyosin contractility in macrophages, by competing with supervillin for myosin IIA activators acting specifically on the β-actin isoform.
format	article
author	Pasquale Cervero Christiane Wiesner Anais Bouissou Renaud Poincloux Stefan Linder
author_facet	Pasquale Cervero Christiane Wiesner Anais Bouissou Renaud Poincloux Stefan Linder
author_sort	Pasquale Cervero
title	Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking
title_short	Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking
title_full	Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking
title_fullStr	Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking
title_full_unstemmed	Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking
title_sort	lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f3f5c58257864c0498c0aecf08fa9c52
work_keys_str_mv	AT pasqualecervero lymphocytespecificprotein1regulatesmechanosensoryoscillationofpodosomesandactinisoformbasedactomyosinsymmetrybreaking AT christianewiesner lymphocytespecificprotein1regulatesmechanosensoryoscillationofpodosomesandactinisoformbasedactomyosinsymmetrybreaking AT anaisbouissou lymphocytespecificprotein1regulatesmechanosensoryoscillationofpodosomesandactinisoformbasedactomyosinsymmetrybreaking AT renaudpoincloux lymphocytespecificprotein1regulatesmechanosensoryoscillationofpodosomesandactinisoformbasedactomyosinsymmetrybreaking AT stefanlinder lymphocytespecificprotein1regulatesmechanosensoryoscillationofpodosomesandactinisoformbasedactomyosinsymmetrybreaking
_version_	1718380709349949440

Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking

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