ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS

We studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, aswell as the production of relevant cytokines by the cells of patients with multiple sclerosis...

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Autores principales:	I. V. Nekrasova, S. V. Shirshev, I. Yu. Danchenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	multiple sclerosis estriol t regulatory lymphocytes th17 lymphocytes cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f3f663ba9e7c488fb106971d8a5966d6
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spelling	oai:doaj.org-article:f3f663ba9e7c488fb106971d8a5966d62021-11-18T08:03:37ZESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS1563-06252313-741X10.15789/1563-0625-2014-1-53-60https://doaj.org/article/f3f663ba9e7c488fb106971d8a5966d62014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/23https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, aswell as the production of relevant cytokines by the cells of patients with multiple sclerosis (MS), as comparedwith healthy donors. It was found that the levels of CD4+FoxP3+CTLA-4+ (Treg) lymphocytes in MS patientswere initially lower than those of healthy donors. Percentages of CD4+RORγt+IL-17A+ (Th17) lymphocytesdid not significantly differ from those in healthy donors, still showing a tendency for increase. Baseline levelsof IL-17 and IL-6 in cell culture supernates of MS patients were higher than in healthy donors, along withreduced contents of the anti-inflammatory IL-10 cytokine. Percentage of Tregs was increased under theinfluence of estriol, whereas Th17 proportion was diminished. These hormonal effects upon lymphocyteswere reproducible both for healthy donors, and MS patients. Moreover, estriol stimulated IL-10 productionand inhibited secretion of IL-6 and IL-17. Therefore, a sufficient release of MS symptoms observed duringpregnancy may be explained by influence of estriol, thus extending opportunities for rational use of this steroidhormone in MS treatmentI. V. NekrasovaS. V. ShirshevI. Yu. DanchenkoSPb RAACIarticlemultiple sclerosisestriolt regulatory lymphocytesth17 lymphocytescytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 1, Pp 53-60 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	multiple sclerosis estriol t regulatory lymphocytes th17 lymphocytes cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	multiple sclerosis estriol t regulatory lymphocytes th17 lymphocytes cytokines Immunologic diseases. Allergy RC581-607 I. V. Nekrasova S. V. Shirshev I. Yu. Danchenko ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS
description	We studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, aswell as the production of relevant cytokines by the cells of patients with multiple sclerosis (MS), as comparedwith healthy donors. It was found that the levels of CD4+FoxP3+CTLA-4+ (Treg) lymphocytes in MS patientswere initially lower than those of healthy donors. Percentages of CD4+RORγt+IL-17A+ (Th17) lymphocytesdid not significantly differ from those in healthy donors, still showing a tendency for increase. Baseline levelsof IL-17 and IL-6 in cell culture supernates of MS patients were higher than in healthy donors, along withreduced contents of the anti-inflammatory IL-10 cytokine. Percentage of Tregs was increased under theinfluence of estriol, whereas Th17 proportion was diminished. These hormonal effects upon lymphocyteswere reproducible both for healthy donors, and MS patients. Moreover, estriol stimulated IL-10 productionand inhibited secretion of IL-6 and IL-17. Therefore, a sufficient release of MS symptoms observed duringpregnancy may be explained by influence of estriol, thus extending opportunities for rational use of this steroidhormone in MS treatment
format	article
author	I. V. Nekrasova S. V. Shirshev I. Yu. Danchenko
author_facet	I. V. Nekrasova S. V. Shirshev I. Yu. Danchenko
author_sort	I. V. Nekrasova
title	ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS
title_short	ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS
title_full	ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS
title_fullStr	ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS
title_full_unstemmed	ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS
title_sort	estriol in functional modulation of regulatory lymphocytes in multiple sclerosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/f3f663ba9e7c488fb106971d8a5966d6
work_keys_str_mv	AT ivnekrasova estriolinfunctionalmodulationofregulatorylymphocytesinmultiplesclerosis AT svshirshev estriolinfunctionalmodulationofregulatorylymphocytesinmultiplesclerosis AT iyudanchenko estriolinfunctionalmodulationofregulatorylymphocytesinmultiplesclerosis
_version_	1718422580031913984

ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS

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