A modality selective effect of functional laterality in pain detection sensitivity

Abstract The ability to detect environmental changes is essential to determine the appropriate reaction when facing potential threats. Both detection and reaction functions are critical to survival, and the superior performance of motor reaction for the dominant hand is well recognized in humans. Ho...

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Autores principales:	Huijuan Zhang, Xuejing Lu, Yanzhi Bi, Li Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f40098d5988e49ce8328c6ec22dea56e
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spelling	oai:doaj.org-article:f40098d5988e49ce8328c6ec22dea56e2021-12-02T17:04:36ZA modality selective effect of functional laterality in pain detection sensitivity10.1038/s41598-021-85111-x2045-2322https://doaj.org/article/f40098d5988e49ce8328c6ec22dea56e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85111-xhttps://doaj.org/toc/2045-2322Abstract The ability to detect environmental changes is essential to determine the appropriate reaction when facing potential threats. Both detection and reaction functions are critical to survival, and the superior performance of motor reaction for the dominant hand is well recognized in humans. However, it is not clear whether there exists laterality in sensitivity to detect external changes and whether the possible laterality is associated with sensory modality and stimulus intensity. Here, we tested whether the perceptual sensitivity and electrophysiological responses elicited by graded sensory stimuli (i.e., nociceptive somatosensory, non-nociceptive somatosensory, auditory, and visual) that were delivered on/near the left and right hands would be different for right-handed individuals. We observed that perceived intensities and most brain responses were significantly larger when nociceptive stimuli were delivered to the left side (i.e., the non-dominant hand) than to the right side (i.e., the dominant hand). No significant difference was observed between the two sides for other modalities. The higher sensitivity to detect nociceptive stimuli for the non-dominant hand would be important to provide a prompt reaction to noxious events, thus compensating for its worse motor performance. This laterality phenomenon should be considered when designing experiments for pain laboratory studies and evaluating regional sensory abnormalities for pain patients.Huijuan ZhangXuejing LuYanzhi BiLi HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huijuan Zhang Xuejing Lu Yanzhi Bi Li Hu A modality selective effect of functional laterality in pain detection sensitivity
description	Abstract The ability to detect environmental changes is essential to determine the appropriate reaction when facing potential threats. Both detection and reaction functions are critical to survival, and the superior performance of motor reaction for the dominant hand is well recognized in humans. However, it is not clear whether there exists laterality in sensitivity to detect external changes and whether the possible laterality is associated with sensory modality and stimulus intensity. Here, we tested whether the perceptual sensitivity and electrophysiological responses elicited by graded sensory stimuli (i.e., nociceptive somatosensory, non-nociceptive somatosensory, auditory, and visual) that were delivered on/near the left and right hands would be different for right-handed individuals. We observed that perceived intensities and most brain responses were significantly larger when nociceptive stimuli were delivered to the left side (i.e., the non-dominant hand) than to the right side (i.e., the dominant hand). No significant difference was observed between the two sides for other modalities. The higher sensitivity to detect nociceptive stimuli for the non-dominant hand would be important to provide a prompt reaction to noxious events, thus compensating for its worse motor performance. This laterality phenomenon should be considered when designing experiments for pain laboratory studies and evaluating regional sensory abnormalities for pain patients.
format	article
author	Huijuan Zhang Xuejing Lu Yanzhi Bi Li Hu
author_facet	Huijuan Zhang Xuejing Lu Yanzhi Bi Li Hu
author_sort	Huijuan Zhang
title	A modality selective effect of functional laterality in pain detection sensitivity
title_short	A modality selective effect of functional laterality in pain detection sensitivity
title_full	A modality selective effect of functional laterality in pain detection sensitivity
title_fullStr	A modality selective effect of functional laterality in pain detection sensitivity
title_full_unstemmed	A modality selective effect of functional laterality in pain detection sensitivity
title_sort	modality selective effect of functional laterality in pain detection sensitivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f40098d5988e49ce8328c6ec22dea56e
work_keys_str_mv	AT huijuanzhang amodalityselectiveeffectoffunctionallateralityinpaindetectionsensitivity AT xuejinglu amodalityselectiveeffectoffunctionallateralityinpaindetectionsensitivity AT yanzhibi amodalityselectiveeffectoffunctionallateralityinpaindetectionsensitivity AT lihu amodalityselectiveeffectoffunctionallateralityinpaindetectionsensitivity AT huijuanzhang modalityselectiveeffectoffunctionallateralityinpaindetectionsensitivity AT xuejinglu modalityselectiveeffectoffunctionallateralityinpaindetectionsensitivity AT yanzhibi modalityselectiveeffectoffunctionallateralityinpaindetectionsensitivity AT lihu modalityselectiveeffectoffunctionallateralityinpaindetectionsensitivity
_version_	1718381885236707328

A modality selective effect of functional laterality in pain detection sensitivity

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