Association of human papilloma virus in oral squamous cell carcinoma: An alarming need for human papillomavirus 16 screening in cancer patients

Background: The percentage of cancers of the tongue and palatine tonsils has continued to increase by 2%–4% among younger men. This increased prevalence of a subsection of oropharyngeal carcinoma can be associated with human papillomavirus (HPV). Among the head-and-neck cancers, a strong association...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Arvind Venkatesh, S Elengkumaran, C Ravindran, N Malathi
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	human papillomavirus oral cancer squamous cell carcinoma Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/f4056a9c39034624ba966b05c27a6136
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f4056a9c39034624ba966b05c27a6136
record_format	dspace
spelling	oai:doaj.org-article:f4056a9c39034624ba966b05c27a61362021-11-19T12:15:52ZAssociation of human papilloma virus in oral squamous cell carcinoma: An alarming need for human papillomavirus 16 screening in cancer patients0975-740610.4103/jpbs.jpbs_370_21https://doaj.org/article/f4056a9c39034624ba966b05c27a61362021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1224;epage=1227;aulast=Venkateshhttps://doaj.org/toc/0975-7406Background: The percentage of cancers of the tongue and palatine tonsils has continued to increase by 2%–4% among younger men. This increased prevalence of a subsection of oropharyngeal carcinoma can be associated with human papillomavirus (HPV). Among the head-and-neck cancers, a strong association with HPV infection is evident with oropharyngeal cancers, particularly tonsillar and basal tongue cancers. Objectives: Oral carcinoma, with an overall incidence of 16.1 adults per 100,000, is one of the leading malignancies worldwide, presenting a noticeable geographic variation in its distribution. Squamous cell carcinoma (SCC) being the most common of all oral malignancies, the objective of the study is to detect the HPV antigen p16 over-expression in patients with oral SCC using immunohistochemistry (IHC). Materials and Methods: Oral SCC (OSCC) diagnosed formalin-fixed-paraffin embedded blocks were processed for IHC. Results: Out of 50 cases, 3 were deferred due to insufficient tumor sample and 2/47 cases were p16 positive and the site was the lateral border of the tongue. Conclusion: The HPV antigen overexpression in patients with OSCC was investigated to detect the incidence of HPV in SCC of oral cavity. P16 was used as a marker for the detection of OSCC using IHC in HPV-induced OSCC. Positives were detected thus concluding the significance of studying HPV expression during diagnosis.Arvind VenkateshS ElengkumaranC RavindranN MalathiWolters Kluwer Medknow Publicationsarticlehuman papillomavirusoral cancersquamous cell carcinomaPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1224-1227 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	human papillomavirus oral cancer squamous cell carcinoma Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	human papillomavirus oral cancer squamous cell carcinoma Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Arvind Venkatesh S Elengkumaran C Ravindran N Malathi Association of human papilloma virus in oral squamous cell carcinoma: An alarming need for human papillomavirus 16 screening in cancer patients
description	Background: The percentage of cancers of the tongue and palatine tonsils has continued to increase by 2%–4% among younger men. This increased prevalence of a subsection of oropharyngeal carcinoma can be associated with human papillomavirus (HPV). Among the head-and-neck cancers, a strong association with HPV infection is evident with oropharyngeal cancers, particularly tonsillar and basal tongue cancers. Objectives: Oral carcinoma, with an overall incidence of 16.1 adults per 100,000, is one of the leading malignancies worldwide, presenting a noticeable geographic variation in its distribution. Squamous cell carcinoma (SCC) being the most common of all oral malignancies, the objective of the study is to detect the HPV antigen p16 over-expression in patients with oral SCC using immunohistochemistry (IHC). Materials and Methods: Oral SCC (OSCC) diagnosed formalin-fixed-paraffin embedded blocks were processed for IHC. Results: Out of 50 cases, 3 were deferred due to insufficient tumor sample and 2/47 cases were p16 positive and the site was the lateral border of the tongue. Conclusion: The HPV antigen overexpression in patients with OSCC was investigated to detect the incidence of HPV in SCC of oral cavity. P16 was used as a marker for the detection of OSCC using IHC in HPV-induced OSCC. Positives were detected thus concluding the significance of studying HPV expression during diagnosis.
format	article
author	Arvind Venkatesh S Elengkumaran C Ravindran N Malathi
author_facet	Arvind Venkatesh S Elengkumaran C Ravindran N Malathi
author_sort	Arvind Venkatesh
title	Association of human papilloma virus in oral squamous cell carcinoma: An alarming need for human papillomavirus 16 screening in cancer patients
title_short	Association of human papilloma virus in oral squamous cell carcinoma: An alarming need for human papillomavirus 16 screening in cancer patients
title_full	Association of human papilloma virus in oral squamous cell carcinoma: An alarming need for human papillomavirus 16 screening in cancer patients
title_fullStr	Association of human papilloma virus in oral squamous cell carcinoma: An alarming need for human papillomavirus 16 screening in cancer patients
title_full_unstemmed	Association of human papilloma virus in oral squamous cell carcinoma: An alarming need for human papillomavirus 16 screening in cancer patients
title_sort	association of human papilloma virus in oral squamous cell carcinoma: an alarming need for human papillomavirus 16 screening in cancer patients
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/f4056a9c39034624ba966b05c27a6136
work_keys_str_mv	AT arvindvenkatesh associationofhumanpapillomavirusinoralsquamouscellcarcinomaanalarmingneedforhumanpapillomavirus16screeningincancerpatients AT selengkumaran associationofhumanpapillomavirusinoralsquamouscellcarcinomaanalarmingneedforhumanpapillomavirus16screeningincancerpatients AT cravindran associationofhumanpapillomavirusinoralsquamouscellcarcinomaanalarmingneedforhumanpapillomavirus16screeningincancerpatients AT nmalathi associationofhumanpapillomavirusinoralsquamouscellcarcinomaanalarmingneedforhumanpapillomavirus16screeningincancerpatients
_version_	1718420168685649920

Association of human papilloma virus in oral squamous cell carcinoma: An alarming need for human papillomavirus 16 screening in cancer patients

Ejemplares similares