Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)

The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juan Torres-Macho, Marcos Sánchez-Fernández, Irene Arnanz-González, Yale Tung-Chen, Ana Isabel Franco-Moreno, Mercedes Duffort-Falcó, Luis Beltrán-Romero, Santiago Rodríguez-Suaréz, Máximo Bernabeu-Wittel, Elena Urbano, Manuel Méndez-Bailon, Fernando Roque-Rojas, Elena García-Guijarro, Gonzalo García-Casasola
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lung ultrasound COVID-19 pneumonia point-of-care ultrasound prognosis Medicine R
Acceso en línea:	https://doaj.org/article/f40782ec16854f4f9db9f17b5c0114eb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f40782ec16854f4f9db9f17b5c0114eb
record_format	dspace
spelling	oai:doaj.org-article:f40782ec16854f4f9db9f17b5c0114eb2021-11-11T17:29:30ZPrediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)10.3390/jcm102148182077-0383https://doaj.org/article/f40782ec16854f4f9db9f17b5c0114eb2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4818https://doaj.org/toc/2077-0383The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (0–48 h and 72–96 h after admission) using a 10-zones sequence, and a 0 to 5 severity score. Primary combined endpoint was death or the need for invasive mechanical ventilation. Calibration (Hosmer–Lemeshow test and calibration curves), and discrimination power (area under the ROC curve) of both ultrasound exams (SCORE1 and 2), and their difference (DIFFERENTIAL-SCORE) were performed. A total of 469 patients (54.2% women, median age 60 years) were included. The primary endpoint occurred in 51 patients (10.9%). Probability risk tertiles of SCORE1 and SCORE2 (0–11 points, 12–24 points, and ≥25 points) obtained a high calibration. SCORE-2 showed a higher discrimination power than SCORE-1 (AUC 0.72 (0.58–0.85) vs. 0.61 (0.52–0.7)). The DIFFERENTIAL-SCORE showed a higher discrimination power than SCORE-1 and SCORE-2 (AUC 0.78 (0.66–0.9)). An algorithm for clinical decision-making is proposed. Serial lung ultrasound performing two examinations during the first days of hospitalization is an accurate strategy for predicting clinical deterioration of patients with COVID-19.Juan Torres-MachoMarcos Sánchez-FernándezIrene Arnanz-GonzálezYale Tung-ChenAna Isabel Franco-MorenoMercedes Duffort-FalcóLuis Beltrán-RomeroSantiago Rodríguez-SuarézMáximo Bernabeu-WittelElena UrbanoManuel Méndez-BailonFernando Roque-RojasElena García-GuijarroGonzalo García-CasasolaMDPI AGarticlelung ultrasoundCOVID-19pneumoniapoint-of-care ultrasoundprognosisMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4818, p 4818 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung ultrasound COVID-19 pneumonia point-of-care ultrasound prognosis Medicine R
spellingShingle	lung ultrasound COVID-19 pneumonia point-of-care ultrasound prognosis Medicine R Juan Torres-Macho Marcos Sánchez-Fernández Irene Arnanz-González Yale Tung-Chen Ana Isabel Franco-Moreno Mercedes Duffort-Falcó Luis Beltrán-Romero Santiago Rodríguez-Suaréz Máximo Bernabeu-Wittel Elena Urbano Manuel Méndez-Bailon Fernando Roque-Rojas Elena García-Guijarro Gonzalo García-Casasola Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
description	The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (0–48 h and 72–96 h after admission) using a 10-zones sequence, and a 0 to 5 severity score. Primary combined endpoint was death or the need for invasive mechanical ventilation. Calibration (Hosmer–Lemeshow test and calibration curves), and discrimination power (area under the ROC curve) of both ultrasound exams (SCORE1 and 2), and their difference (DIFFERENTIAL-SCORE) were performed. A total of 469 patients (54.2% women, median age 60 years) were included. The primary endpoint occurred in 51 patients (10.9%). Probability risk tertiles of SCORE1 and SCORE2 (0–11 points, 12–24 points, and ≥25 points) obtained a high calibration. SCORE-2 showed a higher discrimination power than SCORE-1 (AUC 0.72 (0.58–0.85) vs. 0.61 (0.52–0.7)). The DIFFERENTIAL-SCORE showed a higher discrimination power than SCORE-1 and SCORE-2 (AUC 0.78 (0.66–0.9)). An algorithm for clinical decision-making is proposed. Serial lung ultrasound performing two examinations during the first days of hospitalization is an accurate strategy for predicting clinical deterioration of patients with COVID-19.
format	article
author	Juan Torres-Macho Marcos Sánchez-Fernández Irene Arnanz-González Yale Tung-Chen Ana Isabel Franco-Moreno Mercedes Duffort-Falcó Luis Beltrán-Romero Santiago Rodríguez-Suaréz Máximo Bernabeu-Wittel Elena Urbano Manuel Méndez-Bailon Fernando Roque-Rojas Elena García-Guijarro Gonzalo García-Casasola
author_facet	Juan Torres-Macho Marcos Sánchez-Fernández Irene Arnanz-González Yale Tung-Chen Ana Isabel Franco-Moreno Mercedes Duffort-Falcó Luis Beltrán-Romero Santiago Rodríguez-Suaréz Máximo Bernabeu-Wittel Elena Urbano Manuel Méndez-Bailon Fernando Roque-Rojas Elena García-Guijarro Gonzalo García-Casasola
author_sort	Juan Torres-Macho
title	Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_short	Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_full	Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_fullStr	Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_full_unstemmed	Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)
title_sort	prediction accuracy of serial lung ultrasound in covid-19 hospitalized patients (pred-echovid study)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f40782ec16854f4f9db9f17b5c0114eb
work_keys_str_mv	AT juantorresmacho predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT marcossanchezfernandez predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT irenearnanzgonzalez predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT yaletungchen predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT anaisabelfrancomoreno predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT mercedesduffortfalco predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT luisbeltranromero predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT santiagorodriguezsuarez predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT maximobernabeuwittel predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT elenaurbano predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT manuelmendezbailon predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT fernandoroquerojas predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT elenagarciaguijarro predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy AT gonzalogarciacasasola predictionaccuracyofseriallungultrasoundincovid19hospitalizedpatientspredechovidstudy
_version_	1718432095698681856

Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)

Ejemplares similares