Prevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia

Tesfaye Yesuf, Oumer Abdu Muhie, Habtewold Shibru Department of Internal Medicine, University of Gondar, Gondar, EthiopiaCorrespondence: Oumer Abdu MuhieDepartment of Internal Medicine, University of Gondar, P.O Box 196, Gondar, EthiopiaTel +251 92 163 8680Email umerabdu88@gmail.comBackground: Anemi...

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Autores principales:	Yesuf T, Muhie OA, Shibru H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	HIV AIDS Anemia Gondar Ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f4095add22e340a0823e895a46093dbc
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spelling	oai:doaj.org-article:f4095add22e340a0823e895a46093dbc2021-12-02T11:26:46ZPrevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia1179-1373https://doaj.org/article/f4095add22e340a0823e895a46093dbc2019-09-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-predictors-of-anemia-among-adult-hiv-infected-patients--peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Tesfaye Yesuf, Oumer Abdu Muhie, Habtewold Shibru Department of Internal Medicine, University of Gondar, Gondar, EthiopiaCorrespondence: Oumer Abdu MuhieDepartment of Internal Medicine, University of Gondar, P.O Box 196, Gondar, EthiopiaTel +251 92 163 8680Email umerabdu88@gmail.comBackground: Anemia is the leading hematologic complication of HIV infection occurring in approximately 30% of patients with an asymptomatic infection and in as many as 75–80% of those with AIDS. Anemia increases morbidity and mortality among HIV infected patients.Objective: This study aimed to determine the prevalence of anemia in adult HIV infected patients and the associated factors.Method: Retrospective record review was conducted for a total of 404 HIV infected adult patients who were started on HAART from January 2010 up to September 2015 at the University of Gondar Hospital adult ART clinic. Descriptive analysis, bivariate and multivariate logistic regression was used to compute the different rates, proportions, and associations.Results: The prevalence of anemia was 32.9%, 14.4%, and 9.4% at baseline, after 6 and 12 months of HAART. Lower CD4 count (AOR=1.9; 95% CI: 1.1–3.2) and opportunistic infections (AOR=3.0; 95% CI: 1.8–5.0) were associated with the odds of being anemic at baseline. Baseline anemia was a predictor for being anemic after 6 months (AOR=3.6; 95% CI: 2.0–6.7). Similarly, being anemic after 6 months of HAART predicted the odds of being anemic after 12 months on HAART (AOR=9.1; 95% CI: 4.1–19.9). Zidovudine based regimen was also found to be a predictor of anemia at three months after HAART (AOR=6.0; 95% CI: 2.5–14.3).Conclusion: Anemia is a common problem in HIV patients at the University of Gondar Hospital, nearly a third of the HIV patients had anemia. A lower CD4 count and opportunistic infection were predictors of being anemic. Anemia during the early periods of HAART initiation was also a predictor of subsequent anemia in HIV patients.Keywords: HIV, AIDS, anemia, Gondar, EthiopiaYesuf TMuhie OAShibru HDove Medical PressarticleHIVAIDSAnemiaGondarEthiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 11, Pp 211-217 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV AIDS Anemia Gondar Ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	HIV AIDS Anemia Gondar Ethiopia Immunologic diseases. Allergy RC581-607 Yesuf T Muhie OA Shibru H Prevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia
description	Tesfaye Yesuf, Oumer Abdu Muhie, Habtewold Shibru Department of Internal Medicine, University of Gondar, Gondar, EthiopiaCorrespondence: Oumer Abdu MuhieDepartment of Internal Medicine, University of Gondar, P.O Box 196, Gondar, EthiopiaTel +251 92 163 8680Email umerabdu88@gmail.comBackground: Anemia is the leading hematologic complication of HIV infection occurring in approximately 30% of patients with an asymptomatic infection and in as many as 75–80% of those with AIDS. Anemia increases morbidity and mortality among HIV infected patients.Objective: This study aimed to determine the prevalence of anemia in adult HIV infected patients and the associated factors.Method: Retrospective record review was conducted for a total of 404 HIV infected adult patients who were started on HAART from January 2010 up to September 2015 at the University of Gondar Hospital adult ART clinic. Descriptive analysis, bivariate and multivariate logistic regression was used to compute the different rates, proportions, and associations.Results: The prevalence of anemia was 32.9%, 14.4%, and 9.4% at baseline, after 6 and 12 months of HAART. Lower CD4 count (AOR=1.9; 95% CI: 1.1–3.2) and opportunistic infections (AOR=3.0; 95% CI: 1.8–5.0) were associated with the odds of being anemic at baseline. Baseline anemia was a predictor for being anemic after 6 months (AOR=3.6; 95% CI: 2.0–6.7). Similarly, being anemic after 6 months of HAART predicted the odds of being anemic after 12 months on HAART (AOR=9.1; 95% CI: 4.1–19.9). Zidovudine based regimen was also found to be a predictor of anemia at three months after HAART (AOR=6.0; 95% CI: 2.5–14.3).Conclusion: Anemia is a common problem in HIV patients at the University of Gondar Hospital, nearly a third of the HIV patients had anemia. A lower CD4 count and opportunistic infection were predictors of being anemic. Anemia during the early periods of HAART initiation was also a predictor of subsequent anemia in HIV patients.Keywords: HIV, AIDS, anemia, Gondar, Ethiopia
format	article
author	Yesuf T Muhie OA Shibru H
author_facet	Yesuf T Muhie OA Shibru H
author_sort	Yesuf T
title	Prevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia
title_short	Prevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia
title_full	Prevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia
title_fullStr	Prevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia
title_full_unstemmed	Prevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia
title_sort	prevalence and predictors of anemia among adult hiv infected patients at the university of gondar hospital, northwest ethiopia
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f4095add22e340a0823e895a46093dbc
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Prevalence and predictors of anemia among adult HIV infected patients at the University of Gondar Hospital, Northwest Ethiopia

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