A snapshot of CNVs in the pig genome.

Recent studies of mammalian genomes have uncovered the extent of copy number variation (CNV) that contributes to phenotypic diversity, including health and disease status. Here we report a first account of CNVs in the pig genome covering part of the chromosomes 4, 7, 14, and 17 already sequenced and...

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Autores principales:	João Fadista, Marianne Nygaard, Lars-Erik Holm, Bo Thomsen, Christian Bendixen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f409d31e4b6c42dbab715f8701dcd1ed
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spelling	oai:doaj.org-article:f409d31e4b6c42dbab715f8701dcd1ed2021-11-25T06:18:11ZA snapshot of CNVs in the pig genome.1932-620310.1371/journal.pone.0003916https://doaj.org/article/f409d31e4b6c42dbab715f8701dcd1ed2008-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19079605/?tool=EBIhttps://doaj.org/toc/1932-6203Recent studies of mammalian genomes have uncovered the extent of copy number variation (CNV) that contributes to phenotypic diversity, including health and disease status. Here we report a first account of CNVs in the pig genome covering part of the chromosomes 4, 7, 14, and 17 already sequenced and assembled. A custom tiling oligonucleotide array was used with a median probe spacing of 409 bp for screening 12 unrelated Duroc boars that are founders of a large family material. After a strict CNV calling pipeline, 37 copy number variable regions (CNVRs) across all four chromosomes were identified, with five CNVRs overlapping segmental duplications, three overlapping pig unigenes and one overlapping a RefSeq pig mRNA. This CNV snapshot analysis is the first of its kind in the porcine genome and constitutes the basis for a better understanding of porcine phenotypes and genotypes with the prospect of identifying important economic traits.João FadistaJoão FadistaMarianne NygaardLars-Erik HolmBo ThomsenChristian BendixenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 12, p e3916 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q João Fadista João Fadista Marianne Nygaard Lars-Erik Holm Bo Thomsen Christian Bendixen A snapshot of CNVs in the pig genome.
description	Recent studies of mammalian genomes have uncovered the extent of copy number variation (CNV) that contributes to phenotypic diversity, including health and disease status. Here we report a first account of CNVs in the pig genome covering part of the chromosomes 4, 7, 14, and 17 already sequenced and assembled. A custom tiling oligonucleotide array was used with a median probe spacing of 409 bp for screening 12 unrelated Duroc boars that are founders of a large family material. After a strict CNV calling pipeline, 37 copy number variable regions (CNVRs) across all four chromosomes were identified, with five CNVRs overlapping segmental duplications, three overlapping pig unigenes and one overlapping a RefSeq pig mRNA. This CNV snapshot analysis is the first of its kind in the porcine genome and constitutes the basis for a better understanding of porcine phenotypes and genotypes with the prospect of identifying important economic traits.
format	article
author	João Fadista João Fadista Marianne Nygaard Lars-Erik Holm Bo Thomsen Christian Bendixen
author_facet	João Fadista João Fadista Marianne Nygaard Lars-Erik Holm Bo Thomsen Christian Bendixen
author_sort	João Fadista
title	A snapshot of CNVs in the pig genome.
title_short	A snapshot of CNVs in the pig genome.
title_full	A snapshot of CNVs in the pig genome.
title_fullStr	A snapshot of CNVs in the pig genome.
title_full_unstemmed	A snapshot of CNVs in the pig genome.
title_sort	snapshot of cnvs in the pig genome.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/f409d31e4b6c42dbab715f8701dcd1ed
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A snapshot of CNVs in the pig genome.

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