Cerebellar rTMS and PAS effectively induce cerebellar plasticity

Abstract Non-invasive brain stimulation techniques including repetitive transcranial magnetic stimulation (rTMS), continuous theta-burst stimulation (cTBS), paired associative stimulation (PAS), and transcranial direct current stimulation (tDCS) have been applied over the cerebellum to induce plasti...

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Autores principales:	Martje G. Pauly, Annika Steinmeier, Christina Bolte, Feline Hamami, Elinor Tzvi, Alexander Münchau, Tobias Bäumer, Anne Weissbach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f40ffea0e82d424381acfa3cd506b2f2
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spelling	oai:doaj.org-article:f40ffea0e82d424381acfa3cd506b2f22021-12-02T10:44:21ZCerebellar rTMS and PAS effectively induce cerebellar plasticity10.1038/s41598-021-82496-72045-2322https://doaj.org/article/f40ffea0e82d424381acfa3cd506b2f22021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82496-7https://doaj.org/toc/2045-2322Abstract Non-invasive brain stimulation techniques including repetitive transcranial magnetic stimulation (rTMS), continuous theta-burst stimulation (cTBS), paired associative stimulation (PAS), and transcranial direct current stimulation (tDCS) have been applied over the cerebellum to induce plasticity and gain insights into the interaction of the cerebellum with neo-cortical structures including the motor cortex. We compared the effects of 1 Hz rTMS, cTBS, PAS and tDCS given over the cerebellum on motor cortical excitability and interactions between the cerebellum and dorsal premotor cortex / primary motor cortex in two within subject designs in healthy controls. In experiment 1, rTMS, cTBS, PAS, and tDCS were applied over the cerebellum in 20 healthy subjects. In experiment 2, rTMS and PAS were compared to sham conditions in another group of 20 healthy subjects. In experiment 1, PAS reduced cortical excitability determined by motor evoked potentials (MEP) amplitudes, whereas rTMS increased motor thresholds and facilitated dorsal premotor-motor and cerebellum-motor cortex interactions. TDCS and cTBS had no significant effects. In experiment 2, MEP amplitudes increased after rTMS and motor thresholds following PAS. Analysis of all participants who received rTMS and PAS showed that MEP amplitudes were reduced after PAS and increased following rTMS. rTMS also caused facilitation of dorsal premotor-motor cortex and cerebellum-motor cortex interactions. In summary, cerebellar 1 Hz rTMS and PAS can effectively induce plasticity in cerebello-(premotor)-motor pathways provided larger samples are studied.Martje G. PaulyAnnika SteinmeierChristina BolteFeline HamamiElinor TzviAlexander MünchauTobias BäumerAnne WeissbachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martje G. Pauly Annika Steinmeier Christina Bolte Feline Hamami Elinor Tzvi Alexander Münchau Tobias Bäumer Anne Weissbach Cerebellar rTMS and PAS effectively induce cerebellar plasticity
description	Abstract Non-invasive brain stimulation techniques including repetitive transcranial magnetic stimulation (rTMS), continuous theta-burst stimulation (cTBS), paired associative stimulation (PAS), and transcranial direct current stimulation (tDCS) have been applied over the cerebellum to induce plasticity and gain insights into the interaction of the cerebellum with neo-cortical structures including the motor cortex. We compared the effects of 1 Hz rTMS, cTBS, PAS and tDCS given over the cerebellum on motor cortical excitability and interactions between the cerebellum and dorsal premotor cortex / primary motor cortex in two within subject designs in healthy controls. In experiment 1, rTMS, cTBS, PAS, and tDCS were applied over the cerebellum in 20 healthy subjects. In experiment 2, rTMS and PAS were compared to sham conditions in another group of 20 healthy subjects. In experiment 1, PAS reduced cortical excitability determined by motor evoked potentials (MEP) amplitudes, whereas rTMS increased motor thresholds and facilitated dorsal premotor-motor and cerebellum-motor cortex interactions. TDCS and cTBS had no significant effects. In experiment 2, MEP amplitudes increased after rTMS and motor thresholds following PAS. Analysis of all participants who received rTMS and PAS showed that MEP amplitudes were reduced after PAS and increased following rTMS. rTMS also caused facilitation of dorsal premotor-motor cortex and cerebellum-motor cortex interactions. In summary, cerebellar 1 Hz rTMS and PAS can effectively induce plasticity in cerebello-(premotor)-motor pathways provided larger samples are studied.
format	article
author	Martje G. Pauly Annika Steinmeier Christina Bolte Feline Hamami Elinor Tzvi Alexander Münchau Tobias Bäumer Anne Weissbach
author_facet	Martje G. Pauly Annika Steinmeier Christina Bolte Feline Hamami Elinor Tzvi Alexander Münchau Tobias Bäumer Anne Weissbach
author_sort	Martje G. Pauly
title	Cerebellar rTMS and PAS effectively induce cerebellar plasticity
title_short	Cerebellar rTMS and PAS effectively induce cerebellar plasticity
title_full	Cerebellar rTMS and PAS effectively induce cerebellar plasticity
title_fullStr	Cerebellar rTMS and PAS effectively induce cerebellar plasticity
title_full_unstemmed	Cerebellar rTMS and PAS effectively induce cerebellar plasticity
title_sort	cerebellar rtms and pas effectively induce cerebellar plasticity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f40ffea0e82d424381acfa3cd506b2f2
work_keys_str_mv	AT martjegpauly cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT annikasteinmeier cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT christinabolte cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT felinehamami cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT elinortzvi cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT alexandermunchau cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT tobiasbaumer cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT anneweissbach cerebellarrtmsandpaseffectivelyinducecerebellarplasticity
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Cerebellar rTMS and PAS effectively induce cerebellar plasticity

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