Stromal PTEN determines mammary epithelial response to radiotherapy

The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gina M. Sizemore, Subhasree Balakrishnan, Katie A. Thies, Anisha M. Hammer, Steven T. Sizemore, Anthony J. Trimboli, Maria C. Cuitiño, Sarah A. Steck, Gary Tozbikian, Raleigh D. Kladney, Neelam Shinde, Manjusri Das, Dongju Park, Sarmila Majumder, Shiva Krishnan, Lianbo Yu, Soledad A. Fernandez, Arnab Chakravarti, Peter G. Shields, Julia R. White, Lisa D. Yee, Thomas J. Rosol, Thomas Ludwig, Morag Park, Gustavo Leone, Michael C. Ostrowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4113fd816a74125b1e376f6cb322dab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f4113fd816a74125b1e376f6cb322dab
record_format	dspace
spelling	oai:doaj.org-article:f4113fd816a74125b1e376f6cb322dab2021-12-02T16:49:31ZStromal PTEN determines mammary epithelial response to radiotherapy10.1038/s41467-018-05266-62041-1723https://doaj.org/article/f4113fd816a74125b1e376f6cb322dab2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05266-6https://doaj.org/toc/2041-1723The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperplasia.Gina M. SizemoreSubhasree BalakrishnanKatie A. ThiesAnisha M. HammerSteven T. SizemoreAnthony J. TrimboliMaria C. CuitiñoSarah A. SteckGary TozbikianRaleigh D. KladneyNeelam ShindeManjusri DasDongju ParkSarmila MajumderShiva KrishnanLianbo YuSoledad A. FernandezArnab ChakravartiPeter G. ShieldsJulia R. WhiteLisa D. YeeThomas J. RosolThomas LudwigMorag ParkGustavo LeoneMichael C. OstrowskiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gina M. Sizemore Subhasree Balakrishnan Katie A. Thies Anisha M. Hammer Steven T. Sizemore Anthony J. Trimboli Maria C. Cuitiño Sarah A. Steck Gary Tozbikian Raleigh D. Kladney Neelam Shinde Manjusri Das Dongju Park Sarmila Majumder Shiva Krishnan Lianbo Yu Soledad A. Fernandez Arnab Chakravarti Peter G. Shields Julia R. White Lisa D. Yee Thomas J. Rosol Thomas Ludwig Morag Park Gustavo Leone Michael C. Ostrowski Stromal PTEN determines mammary epithelial response to radiotherapy
description	The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperplasia.
format	article
author	Gina M. Sizemore Subhasree Balakrishnan Katie A. Thies Anisha M. Hammer Steven T. Sizemore Anthony J. Trimboli Maria C. Cuitiño Sarah A. Steck Gary Tozbikian Raleigh D. Kladney Neelam Shinde Manjusri Das Dongju Park Sarmila Majumder Shiva Krishnan Lianbo Yu Soledad A. Fernandez Arnab Chakravarti Peter G. Shields Julia R. White Lisa D. Yee Thomas J. Rosol Thomas Ludwig Morag Park Gustavo Leone Michael C. Ostrowski
author_facet	Gina M. Sizemore Subhasree Balakrishnan Katie A. Thies Anisha M. Hammer Steven T. Sizemore Anthony J. Trimboli Maria C. Cuitiño Sarah A. Steck Gary Tozbikian Raleigh D. Kladney Neelam Shinde Manjusri Das Dongju Park Sarmila Majumder Shiva Krishnan Lianbo Yu Soledad A. Fernandez Arnab Chakravarti Peter G. Shields Julia R. White Lisa D. Yee Thomas J. Rosol Thomas Ludwig Morag Park Gustavo Leone Michael C. Ostrowski
author_sort	Gina M. Sizemore
title	Stromal PTEN determines mammary epithelial response to radiotherapy
title_short	Stromal PTEN determines mammary epithelial response to radiotherapy
title_full	Stromal PTEN determines mammary epithelial response to radiotherapy
title_fullStr	Stromal PTEN determines mammary epithelial response to radiotherapy
title_full_unstemmed	Stromal PTEN determines mammary epithelial response to radiotherapy
title_sort	stromal pten determines mammary epithelial response to radiotherapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f4113fd816a74125b1e376f6cb322dab
work_keys_str_mv	AT ginamsizemore stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT subhasreebalakrishnan stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT katieathies stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT anishamhammer stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT steventsizemore stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT anthonyjtrimboli stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT mariaccuitino stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT sarahasteck stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT garytozbikian stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT raleighdkladney stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT neelamshinde stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT manjusridas stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT dongjupark stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT sarmilamajumder stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT shivakrishnan stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT lianboyu stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT soledadafernandez stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT arnabchakravarti stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT petergshields stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT juliarwhite stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT lisadyee stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT thomasjrosol stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT thomasludwig stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT moragpark stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT gustavoleone stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT michaelcostrowski stromalptendeterminesmammaryepithelialresponsetoradiotherapy
_version_	1718383312341303296

Stromal PTEN determines mammary epithelial response to radiotherapy

Ejemplares similares