Stromal PTEN determines mammary epithelial response to radiotherapy

Stromal PTEN determines mammary epithelial response to radiotherapy

The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperp...

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Auteurs principaux: Gina M. Sizemore, Subhasree Balakrishnan, Katie A. Thies, Anisha M. Hammer, Steven T. Sizemore, Anthony J. Trimboli, Maria C. Cuitiño, Sarah A. Steck, Gary Tozbikian, Raleigh D. Kladney, Neelam Shinde, Manjusri Das, Dongju Park, Sarmila Majumder, Shiva Krishnan, Lianbo Yu, Soledad A. Fernandez, Arnab Chakravarti, Peter G. Shields, Julia R. White, Lisa D. Yee, Thomas J. Rosol, Thomas Ludwig, Morag Park, Gustavo Leone, Michael C. Ostrowski
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Science
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Accès en ligne:https://doaj.org/article/f4113fd816a74125b1e376f6cb322dab
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Internet

https://doaj.org/article/f4113fd816a74125b1e376f6cb322dab

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