Stromal PTEN determines mammary epithelial response to radiotherapy

Stromal PTEN determines mammary epithelial response to radiotherapy

The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperp...

Full description

Saved in:
Bibliographic Details
Main Authors: Gina M. Sizemore, Subhasree Balakrishnan, Katie A. Thies, Anisha M. Hammer, Steven T. Sizemore, Anthony J. Trimboli, Maria C. Cuitiño, Sarah A. Steck, Gary Tozbikian, Raleigh D. Kladney, Neelam Shinde, Manjusri Das, Dongju Park, Sarmila Majumder, Shiva Krishnan, Lianbo Yu, Soledad A. Fernandez, Arnab Chakravarti, Peter G. Shields, Julia R. White, Lisa D. Yee, Thomas J. Rosol, Thomas Ludwig, Morag Park, Gustavo Leone, Michael C. Ostrowski
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/f4113fd816a74125b1e376f6cb322dab
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items