Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance

Pinakin Gunvant Davey, Silverio D Alvarez, Jessica Y Lee College of Optometry, Western University of Health Sciences, Pomona, CA, USA Purpose: To evaluate short-term repeatability, intereye correlation, and effect of ocular dominance on macular pigment optical density (MPOD) measurements obtained...

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Autores principales:	Davey PG, Alvarez SD, Lee JY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Macular pigment optical density Heterochromatic Flicker Photometry Age Related Macular Degeneration Ocular dominance QuantifEye Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f413535102bb482b97d6291e701e01e7
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spelling	oai:doaj.org-article:f413535102bb482b97d6291e701e01e72021-12-02T01:02:56ZMacular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance1177-5483https://doaj.org/article/f413535102bb482b97d6291e701e01e72016-08-01T00:00:00Zhttps://www.dovepress.com/macular-pigment-optical-density-repeatability-intereye-correlation-and-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Pinakin Gunvant Davey, Silverio D Alvarez, Jessica Y Lee College of Optometry, Western University of Health Sciences, Pomona, CA, USA Purpose: To evaluate short-term repeatability, intereye correlation, and effect of ocular dominance on macular pigment optical density (MPOD) measurements obtained using the QuantifEye Heterochromatic Flicker Photometer.Patients and methods: A total of 72 study participants were enrolled in this prospective, cross-sectional study. Participants underwent a comprehensive ocular evaluation, including visual acuity, evaluation of ocular dominance, slit lamp examination, intraocular pressure measurement, and optic nerve head and macula analysis using optical coherence tomography and fundus photography. All study participants after initial training underwent MPOD measurement twice in both eyes in a randomized sequence. The repeatability was tested using Altman and Bland plots for first measurements with the second measurements for right eye and left eye and additionally by grouping eyes as a function of ocular dominance. The Pearson correlation coefficient was performed to assess the intereye correlation of MPOD values.Results: The mean age of study participants was 35.5 years (range 22–68 years). The mean MPOD measurements for OD (right eye) and OS (left eye) were 0.47 and 0.48, respectively, which followed a normal distribution (Shapiro–Wilk test, P=0.6 and 0.2). The 95% limits of agreement of Altman and Bland plots for the first and second measurements were -0.12 to +0.11 and -0.13 to +0.12 for OD and OS, respectively. The correlation coefficient of mean MPOD measurements of OD and OS was r statistic =0.94 (Pearson correlation coefficient P<0.0001; r2 0.89). The 95% limits of agreement of Altman and Bland plots when evaluated by laterality of eye or by ocular dominance were narrow, with limits of agreement ranging from -0.13 to +0.12.Conclusion: The MPOD measurements obtained using the QuantifEye show good short-term repeatability. There is excellent intereye correlation, indicating that the MPOD values of one eye data can predict the fellow eye value with 89% accuracy. The ocular dominance had no bearing on the outcome of this psychophysical test in ocular healthy eyes. Keywords: macular pigment optical density, heterochromatic flicker photometry, age-related macular degeneration, ocular dominance, QuantifEye, repeatability, clinical protocolDavey PGAlvarez SDLee JYDove Medical PressarticleMacular pigment optical densityHeterochromatic Flicker PhotometryAge Related Macular DegenerationOcular dominanceQuantifEyeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 1671-1678 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Macular pigment optical density Heterochromatic Flicker Photometry Age Related Macular Degeneration Ocular dominance QuantifEye Ophthalmology RE1-994
spellingShingle	Macular pigment optical density Heterochromatic Flicker Photometry Age Related Macular Degeneration Ocular dominance QuantifEye Ophthalmology RE1-994 Davey PG Alvarez SD Lee JY Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance
description	Pinakin Gunvant Davey, Silverio D Alvarez, Jessica Y Lee College of Optometry, Western University of Health Sciences, Pomona, CA, USA Purpose: To evaluate short-term repeatability, intereye correlation, and effect of ocular dominance on macular pigment optical density (MPOD) measurements obtained using the QuantifEye Heterochromatic Flicker Photometer.Patients and methods: A total of 72 study participants were enrolled in this prospective, cross-sectional study. Participants underwent a comprehensive ocular evaluation, including visual acuity, evaluation of ocular dominance, slit lamp examination, intraocular pressure measurement, and optic nerve head and macula analysis using optical coherence tomography and fundus photography. All study participants after initial training underwent MPOD measurement twice in both eyes in a randomized sequence. The repeatability was tested using Altman and Bland plots for first measurements with the second measurements for right eye and left eye and additionally by grouping eyes as a function of ocular dominance. The Pearson correlation coefficient was performed to assess the intereye correlation of MPOD values.Results: The mean age of study participants was 35.5 years (range 22–68 years). The mean MPOD measurements for OD (right eye) and OS (left eye) were 0.47 and 0.48, respectively, which followed a normal distribution (Shapiro–Wilk test, P=0.6 and 0.2). The 95% limits of agreement of Altman and Bland plots for the first and second measurements were -0.12 to +0.11 and -0.13 to +0.12 for OD and OS, respectively. The correlation coefficient of mean MPOD measurements of OD and OS was r statistic =0.94 (Pearson correlation coefficient P<0.0001; r2 0.89). The 95% limits of agreement of Altman and Bland plots when evaluated by laterality of eye or by ocular dominance were narrow, with limits of agreement ranging from -0.13 to +0.12.Conclusion: The MPOD measurements obtained using the QuantifEye show good short-term repeatability. There is excellent intereye correlation, indicating that the MPOD values of one eye data can predict the fellow eye value with 89% accuracy. The ocular dominance had no bearing on the outcome of this psychophysical test in ocular healthy eyes. Keywords: macular pigment optical density, heterochromatic flicker photometry, age-related macular degeneration, ocular dominance, QuantifEye, repeatability, clinical protocol
format	article
author	Davey PG Alvarez SD Lee JY
author_facet	Davey PG Alvarez SD Lee JY
author_sort	Davey PG
title	Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance
title_short	Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance
title_full	Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance
title_fullStr	Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance
title_full_unstemmed	Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance
title_sort	macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/f413535102bb482b97d6291e701e01e7
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_version_	1718403353177751552

Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance

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