The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside

Menstruation, the cyclical breakdown of the uterine lining, is arguably one of evolution's most mysterious reproductive strategies. The complexity and rarity of menstruation within the animal kingdom is undoubtedly a leading contributor to our current lack of understanding about menstrual funct...

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Autores principales:	Nadia Bellofiore, Jarrod McKenna, Stacey Ellery, Peter Temple-Smith
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	menstruating mouse model DHEA abnormal uterine bleeding preeclampsia angiogenesis uterus Reproduction QH471-489 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f417b28ba37347628d1e0847682df842
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spelling	oai:doaj.org-article:f417b28ba37347628d1e0847682df8422021-12-01T07:17:53ZThe Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside2673-315310.3389/frph.2021.784578https://doaj.org/article/f417b28ba37347628d1e0847682df8422021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/frph.2021.784578/fullhttps://doaj.org/toc/2673-3153Menstruation, the cyclical breakdown of the uterine lining, is arguably one of evolution's most mysterious reproductive strategies. The complexity and rarity of menstruation within the animal kingdom is undoubtedly a leading contributor to our current lack of understanding about menstrual function and disorders. In particular, the molecular and environmental mechanisms that drive menstrual and fertility dysregulation remain ambiguous, owing to the restricted opportunities to study menstruation and model menstrual disorders in species outside the primates. The recent discovery of naturally occurring menstruation in the Egyptian spiny mouse (Acomys cahirinus) offers a new laboratory model with significant benefits for prospective research in women's health. This review summarises current knowledge of spiny mouse menstruation, with an emphasis on spiral artery formation, inflammation and endocrinology. We offer a new perspective on cycle variation in menstrual bleeding between individual animals, and propose that this is indicative of fertility success. We discuss how we can harness our knowledge of the unique physiology of the spiny mouse to better understand vascular remodelling and its implications for successful implantation, placentation, and foetal development. Our research suggests that the spiny mouse has the potential as a translational research model to bridge the gap between bench to bedside and provide improved reproductive health outcomes for women.Nadia BellofioreNadia BellofioreJarrod McKennaStacey ElleryStacey ElleryPeter Temple-SmithFrontiers Media S.A.articlemenstruating mouse modelDHEAabnormal uterine bleedingpreeclampsiaangiogenesisuterusReproductionQH471-489Medicine (General)R5-920ENFrontiers in Reproductive Health, Vol 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	menstruating mouse model DHEA abnormal uterine bleeding preeclampsia angiogenesis uterus Reproduction QH471-489 Medicine (General) R5-920
spellingShingle	menstruating mouse model DHEA abnormal uterine bleeding preeclampsia angiogenesis uterus Reproduction QH471-489 Medicine (General) R5-920 Nadia Bellofiore Nadia Bellofiore Jarrod McKenna Stacey Ellery Stacey Ellery Peter Temple-Smith The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside
description	Menstruation, the cyclical breakdown of the uterine lining, is arguably one of evolution's most mysterious reproductive strategies. The complexity and rarity of menstruation within the animal kingdom is undoubtedly a leading contributor to our current lack of understanding about menstrual function and disorders. In particular, the molecular and environmental mechanisms that drive menstrual and fertility dysregulation remain ambiguous, owing to the restricted opportunities to study menstruation and model menstrual disorders in species outside the primates. The recent discovery of naturally occurring menstruation in the Egyptian spiny mouse (Acomys cahirinus) offers a new laboratory model with significant benefits for prospective research in women's health. This review summarises current knowledge of spiny mouse menstruation, with an emphasis on spiral artery formation, inflammation and endocrinology. We offer a new perspective on cycle variation in menstrual bleeding between individual animals, and propose that this is indicative of fertility success. We discuss how we can harness our knowledge of the unique physiology of the spiny mouse to better understand vascular remodelling and its implications for successful implantation, placentation, and foetal development. Our research suggests that the spiny mouse has the potential as a translational research model to bridge the gap between bench to bedside and provide improved reproductive health outcomes for women.
format	article
author	Nadia Bellofiore Nadia Bellofiore Jarrod McKenna Stacey Ellery Stacey Ellery Peter Temple-Smith
author_facet	Nadia Bellofiore Nadia Bellofiore Jarrod McKenna Stacey Ellery Stacey Ellery Peter Temple-Smith
author_sort	Nadia Bellofiore
title	The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside
title_short	The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside
title_full	The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside
title_fullStr	The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside
title_full_unstemmed	The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside
title_sort	spiny mouse—a menstruating rodent to build a bridge from bench to bedside
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f417b28ba37347628d1e0847682df842
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The Spiny Mouse—A Menstruating Rodent to Build a Bridge From Bench to Bedside

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