Anxiolytics may promote locomotor function recovery in spinal cord injury patients

Pierre A GuertinNeuroscience Unit, Laval University Medical Center (CHUL), Quebec City, CanadaAbstract: Recent findings in animal models of paraplegia suggest that specific nonbenzodiazepine anxiolytics may temporarily restore locomotor functions after spinal cord injury (SCI). Experiments using in...

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Autor principal:	Pierre A Guertin
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f41864b083a24af1922bef312e67addf
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spelling	oai:doaj.org-article:f41864b083a24af1922bef312e67addf2021-12-02T04:21:37ZAnxiolytics may promote locomotor function recovery in spinal cord injury patients1176-63281178-2021https://doaj.org/article/f41864b083a24af1922bef312e67addf2008-09-01T00:00:00Zhttp://www.dovepress.com/anxiolytics-may-promote-locomotor-function-recovery-in-spinal-cord-inj-a2201https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Pierre A GuertinNeuroscience Unit, Laval University Medical Center (CHUL), Quebec City, CanadaAbstract: Recent findings in animal models of paraplegia suggest that specific nonbenzodiazepine anxiolytics may temporarily restore locomotor functions after spinal cord injury (SCI). Experiments using in vitro models have revealed, indeed, that selective serotonin receptor (5-HTR) ligands such as 5-HTR1A agonists, known as relatively safe anxiolytics, can acutely elicit episodes of rhythmic neuronal activity refered to as fictive locomotion in isolated spinal cord preparations. Along the same line, in vivo studies have recently shown that this subclass of anxiolytics can induce, shortly after systemic administration (eg, orally or subcutaneously), some locomotor-like hindlimb movements during 45&ndash;60 minutes in completely spinal cord-transected (Tx) rodents. Using &lsquo;knock-out&rsquo; mice (eg, 5-HTR7-/-) and selective antagonists, it has been clearly established that both 5-HTR1A and 5-HTR7 were critically involved in mediating the pro-locomotor effects induced by 8-OH-DPAT (typically referred to as a 5-HTR1A agonist) in Tx animals. Taken together, these in vitro and in vivo data strongly support the idea that 5-HTR1A agonists may eventually become constitutive elements of a novel first-in-class combinatorial treatment aimed at periodically inducing short episodes of treadmill stepping in SCI patients.Keywords: 5-HT agonists, anxiolytics, locomotion, SCI Pierre A GuertinDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 4, Pp 759-763 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pierre A Guertin Anxiolytics may promote locomotor function recovery in spinal cord injury patients
description	Pierre A GuertinNeuroscience Unit, Laval University Medical Center (CHUL), Quebec City, CanadaAbstract: Recent findings in animal models of paraplegia suggest that specific nonbenzodiazepine anxiolytics may temporarily restore locomotor functions after spinal cord injury (SCI). Experiments using in vitro models have revealed, indeed, that selective serotonin receptor (5-HTR) ligands such as 5-HTR1A agonists, known as relatively safe anxiolytics, can acutely elicit episodes of rhythmic neuronal activity refered to as fictive locomotion in isolated spinal cord preparations. Along the same line, in vivo studies have recently shown that this subclass of anxiolytics can induce, shortly after systemic administration (eg, orally or subcutaneously), some locomotor-like hindlimb movements during 45&ndash;60 minutes in completely spinal cord-transected (Tx) rodents. Using &lsquo;knock-out&rsquo; mice (eg, 5-HTR7-/-) and selective antagonists, it has been clearly established that both 5-HTR1A and 5-HTR7 were critically involved in mediating the pro-locomotor effects induced by 8-OH-DPAT (typically referred to as a 5-HTR1A agonist) in Tx animals. Taken together, these in vitro and in vivo data strongly support the idea that 5-HTR1A agonists may eventually become constitutive elements of a novel first-in-class combinatorial treatment aimed at periodically inducing short episodes of treadmill stepping in SCI patients.Keywords: 5-HT agonists, anxiolytics, locomotion, SCI
format	article
author	Pierre A Guertin
author_facet	Pierre A Guertin
author_sort	Pierre A Guertin
title	Anxiolytics may promote locomotor function recovery in spinal cord injury patients
title_short	Anxiolytics may promote locomotor function recovery in spinal cord injury patients
title_full	Anxiolytics may promote locomotor function recovery in spinal cord injury patients
title_fullStr	Anxiolytics may promote locomotor function recovery in spinal cord injury patients
title_full_unstemmed	Anxiolytics may promote locomotor function recovery in spinal cord injury patients
title_sort	anxiolytics may promote locomotor function recovery in spinal cord injury patients
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/f41864b083a24af1922bef312e67addf
work_keys_str_mv	AT pierreaguertin anxiolyticsmaypromotelocomotorfunctionrecoveryinspinalcordinjurypatients
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Anxiolytics may promote locomotor function recovery in spinal cord injury patients

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