Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats

Yazachew Engida Yismaw,1 Mohammedbrhan Abdelwuhab,2 Digambar B Ambikar,2 Ayenew Engida Yismaw,3 Dagninet Derebe,1 Wondim Melkam1 1Bahir Dar University, College of Medicine and Health Science, School of Health Science, Bahir Dar, Ethiopia; 2University of Gondar, College of Medicine and Health Science...

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Autores principales:	Yismaw YE, Abdelwuhab M, Ambikar DB, Yismaw AE, Derebe D, Melkam W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	antiulcer cordia africana seeds pylorus ligation ulcer parameters ulcer score ulcer index percent protection Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f4186e56cece4b5ca81abeffb8a139c9
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spelling	oai:doaj.org-article:f4186e56cece4b5ca81abeffb8a139c92021-12-02T11:23:15ZPhytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats1179-1438https://doaj.org/article/f4186e56cece4b5ca81abeffb8a139c92020-06-01T00:00:00Zhttps://www.dovepress.com/phytochemical-and-antiulcer-activity-screening-of-seed-extract-of-cord-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Yazachew Engida Yismaw,1 Mohammedbrhan Abdelwuhab,2 Digambar B Ambikar,2 Ayenew Engida Yismaw,3 Dagninet Derebe,1 Wondim Melkam1 1Bahir Dar University, College of Medicine and Health Science, School of Health Science, Bahir Dar, Ethiopia; 2University of Gondar, College of Medicine and Health Science, School of Pharmacy, Gondar, Ethiopia; 3University of Gondar, College of Medicine and Health Science, School of Health Science, Gondar, EthiopiaCorrespondence: Yazachew Engida Yismaw Email yachewable@gmail.comIntroduction: Peptic ulcer disease represents a worldwide health problem because of its high morbidity, mortality and economic loss. It is a very prevalent condition affecting around 10%– 15% of the general population worldwide. Most of the available antiulcer drugs are costly and have an incidence of relapse, drug interactions and several side effects upon chronic usage. Hence, the use of herbal medicine may be safe, economical and effective in such cases when drugs are used for long periods. Ethnobotanical reports showed traditional claims on the use of Cordia africana seeds for the treatment of gastric ulcers. However, the safety and efficacy of these remedies are not well known. The aim of this study is, therefore, to evaluate the antiulcer activity and safety of a crude extract of C. africana seeds in animal models.Methods: Shade-dried seeds of C. africana were extracted by 80% methanol and dried by the rotator evaporator and lyophilized. The crude extract was used to evaluate antiulcer activity in vivo with pylorus ligation method, on Wistar albino rats weighing 230– 250g. Preliminary phytochemical screening was performed using a standard procedure. Acute toxicity study was carried out in Swiss albino mice before antiulcer activity tests.Results: No sign of toxicity was observed upon the administration of 2000 mg/kg of the crude extract to mice. Single-dose administration of 400 and 600 mg/kg extract showed a significant reduction in the volume of secretion and acidity of the stomach (p < 0.01). The doses 400 and 600 mg/kg have reduced the ulcer score by 83.58% and 88%.Conclusion: The result of this study showed that the hydromethanolic crude extract of C. africana has strong antisecretory and ulcer protective activities against ulcers produced by pylorus ligation.Keywords: antiulcer, Cordia africana, seeds, pylorus ligation, ulcer parameters, ulcer score, ulcer index, percent protectionYismaw YEAbdelwuhab MAmbikar DBYismaw AEDerebe DMelkam WDove Medical Pressarticleantiulcercordia africanaseedspylorus ligationulcer parametersulcer scoreulcer indexpercent protectionTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 12, Pp 67-73 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antiulcer cordia africana seeds pylorus ligation ulcer parameters ulcer score ulcer index percent protection Therapeutics. Pharmacology RM1-950
spellingShingle	antiulcer cordia africana seeds pylorus ligation ulcer parameters ulcer score ulcer index percent protection Therapeutics. Pharmacology RM1-950 Yismaw YE Abdelwuhab M Ambikar DB Yismaw AE Derebe D Melkam W Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats
description	Yazachew Engida Yismaw,1 Mohammedbrhan Abdelwuhab,2 Digambar B Ambikar,2 Ayenew Engida Yismaw,3 Dagninet Derebe,1 Wondim Melkam1 1Bahir Dar University, College of Medicine and Health Science, School of Health Science, Bahir Dar, Ethiopia; 2University of Gondar, College of Medicine and Health Science, School of Pharmacy, Gondar, Ethiopia; 3University of Gondar, College of Medicine and Health Science, School of Health Science, Gondar, EthiopiaCorrespondence: Yazachew Engida Yismaw Email yachewable@gmail.comIntroduction: Peptic ulcer disease represents a worldwide health problem because of its high morbidity, mortality and economic loss. It is a very prevalent condition affecting around 10%– 15% of the general population worldwide. Most of the available antiulcer drugs are costly and have an incidence of relapse, drug interactions and several side effects upon chronic usage. Hence, the use of herbal medicine may be safe, economical and effective in such cases when drugs are used for long periods. Ethnobotanical reports showed traditional claims on the use of Cordia africana seeds for the treatment of gastric ulcers. However, the safety and efficacy of these remedies are not well known. The aim of this study is, therefore, to evaluate the antiulcer activity and safety of a crude extract of C. africana seeds in animal models.Methods: Shade-dried seeds of C. africana were extracted by 80% methanol and dried by the rotator evaporator and lyophilized. The crude extract was used to evaluate antiulcer activity in vivo with pylorus ligation method, on Wistar albino rats weighing 230– 250g. Preliminary phytochemical screening was performed using a standard procedure. Acute toxicity study was carried out in Swiss albino mice before antiulcer activity tests.Results: No sign of toxicity was observed upon the administration of 2000 mg/kg of the crude extract to mice. Single-dose administration of 400 and 600 mg/kg extract showed a significant reduction in the volume of secretion and acidity of the stomach (p < 0.01). The doses 400 and 600 mg/kg have reduced the ulcer score by 83.58% and 88%.Conclusion: The result of this study showed that the hydromethanolic crude extract of C. africana has strong antisecretory and ulcer protective activities against ulcers produced by pylorus ligation.Keywords: antiulcer, Cordia africana, seeds, pylorus ligation, ulcer parameters, ulcer score, ulcer index, percent protection
format	article
author	Yismaw YE Abdelwuhab M Ambikar DB Yismaw AE Derebe D Melkam W
author_facet	Yismaw YE Abdelwuhab M Ambikar DB Yismaw AE Derebe D Melkam W
author_sort	Yismaw YE
title	Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats
title_short	Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats
title_full	Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats
title_fullStr	Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats
title_full_unstemmed	Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats
title_sort	phytochemical and antiulcer activity screening of seed extract of cordia africana lam (boraginaceae) in pyloric ligated rats
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f4186e56cece4b5ca81abeffb8a139c9
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Phytochemical and Antiulcer Activity Screening of Seed Extract of Cordia africana Lam (Boraginaceae) in Pyloric Ligated Rats

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