Preparation of Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application

This study aimed to formulate sodium lauryl sulfate cross-linked chitosan beads and sodium alginate-chitosan films for designing a dressing that would shorten the healing time of skin wounds. Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads (CH-SLS) and chitosan-alginate (CH-ALG)...

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Autores principales:	Mariem Kharroubi, Fatima Bellali, Abdelhafid Karrat, Mohamed Bouchdoug, Abderrahim Jaouad
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	chitosan-sodium lauryl sulfate beads chitosan-alginate films characterization teucrium polium wound dressing wound healing Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/f4193c3a755b4e30a2ebd93eecd4aebc
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spelling	oai:doaj.org-article:f4193c3a755b4e30a2ebd93eecd4aebc2021-11-30T01:46:44ZPreparation of Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application10.3934/publichealth.20210592327-8994https://doaj.org/article/f4193c3a755b4e30a2ebd93eecd4aebc2021-10-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/publichealth.2021059?viewType=HTMLhttps://doaj.org/toc/2327-8994This study aimed to formulate sodium lauryl sulfate cross-linked chitosan beads and sodium alginate-chitosan films for designing a dressing that would shorten the healing time of skin wounds. Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads (CH-SLS) and chitosan-alginate (CH-ALG) films were prepared and characterized by using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) analysis, and scanning electron microscopy (SEM). The swelling properties of the CH-SLS beads were also analyzed in a water solution. The obtained Teucrium polium extract-loaded CH-SLS beads and CH-ALG films (TBF) were further incorporated into the commercial adhesive dressing. This TBF wound dressing was then investigated for evaluation of its wound healing potential in the mice using the excision wound model. Healing was assessed by the macroscopic appearance and the rate of wound contraction during 8 days. On day 4, the TBF-treated wounds exhibited 98% reduction in the wound area when they were compared with healing ointment, elastic adhesive dressing, and untreated wounds which were exhibited 63%, 43%, and 32%, respectively. Furthermore, the application of TBF dressing reduced skin wound rank scores and increased the percentage of wounds contraction. These results demonstrate that TBF dressing improves considerably the healing rate and the macroscopic wound appearance at a short delay and this application may have therapeutic benefits in wound healing.Mariem Kharroubi Fatima BellaliAbdelhafid KarratMohamed BouchdougAbderrahim JaouadAIMS Pressarticlechitosan-sodium lauryl sulfate beadschitosan-alginate filmscharacterizationteucrium poliumwound dressingwound healingPublic aspects of medicineRA1-1270ENAIMS Public Health, Vol 8, Iss 4, Pp 754-775 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan-sodium lauryl sulfate beads chitosan-alginate films characterization teucrium polium wound dressing wound healing Public aspects of medicine RA1-1270
spellingShingle	chitosan-sodium lauryl sulfate beads chitosan-alginate films characterization teucrium polium wound dressing wound healing Public aspects of medicine RA1-1270 Mariem Kharroubi Fatima Bellali Abdelhafid Karrat Mohamed Bouchdoug Abderrahim Jaouad Preparation of Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application
description	This study aimed to formulate sodium lauryl sulfate cross-linked chitosan beads and sodium alginate-chitosan films for designing a dressing that would shorten the healing time of skin wounds. Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads (CH-SLS) and chitosan-alginate (CH-ALG) films were prepared and characterized by using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) analysis, and scanning electron microscopy (SEM). The swelling properties of the CH-SLS beads were also analyzed in a water solution. The obtained Teucrium polium extract-loaded CH-SLS beads and CH-ALG films (TBF) were further incorporated into the commercial adhesive dressing. This TBF wound dressing was then investigated for evaluation of its wound healing potential in the mice using the excision wound model. Healing was assessed by the macroscopic appearance and the rate of wound contraction during 8 days. On day 4, the TBF-treated wounds exhibited 98% reduction in the wound area when they were compared with healing ointment, elastic adhesive dressing, and untreated wounds which were exhibited 63%, 43%, and 32%, respectively. Furthermore, the application of TBF dressing reduced skin wound rank scores and increased the percentage of wounds contraction. These results demonstrate that TBF dressing improves considerably the healing rate and the macroscopic wound appearance at a short delay and this application may have therapeutic benefits in wound healing.
format	article
author	Mariem Kharroubi Fatima Bellali Abdelhafid Karrat Mohamed Bouchdoug Abderrahim Jaouad
author_facet	Mariem Kharroubi Fatima Bellali Abdelhafid Karrat Mohamed Bouchdoug Abderrahim Jaouad
author_sort	Mariem Kharroubi
title	Preparation of Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application
title_short	Preparation of Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application
title_full	Preparation of Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application
title_fullStr	Preparation of Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application
title_full_unstemmed	Preparation of Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application
title_sort	preparation of teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/f4193c3a755b4e30a2ebd93eecd4aebc
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Preparation of Teucrium polium extract-loaded chitosan-sodium lauryl sulfate beads and chitosan-alginate films for wound dressing application

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