Stress-Induced Loss of Heterozygosity in <italic toggle="yes">Candida</italic>: a Possible Missing Link in the Ability to Evolve

ABSTRACT Diploid organisms are buffered against the effects of mutations by carrying two sets of each gene, which allows compensation if one is mutated. But recombination between “mom” and “dad” chromosomes causes loss of heterozygosity (LOH), stretches of “mom-only” or “dad-only” DNA sequence, sudd...

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Autor principal:	Susan M. Rosenberg
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2011
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f41bf30533f04a5693dab78556c01e75
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spelling	oai:doaj.org-article:f41bf30533f04a5693dab78556c01e752021-11-15T15:38:58ZStress-Induced Loss of Heterozygosity in <italic toggle="yes">Candida</italic>: a Possible Missing Link in the Ability to Evolve10.1128/mBio.00200-112150-7511https://doaj.org/article/f41bf30533f04a5693dab78556c01e752011-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00200-11https://doaj.org/toc/2150-7511ABSTRACT Diploid organisms are buffered against the effects of mutations by carrying two sets of each gene, which allows compensation if one is mutated. But recombination between “mom” and “dad” chromosomes causes loss of heterozygosity (LOH), stretches of “mom-only” or “dad-only” DNA sequence, suddenly revealing effects of mutations accumulated in entire chromosome arms. LOH creates new phenotypes from old mutations, drives cancer development and evolution, and, in a new study by Forche et al., is shown to be induced by stress in Candida albicans [Forche A, et al, mBio 2(4):e00129-11, 2011]. Stress-induced LOH could speed evolution of Candida specifically when it is poorly adapted to its environment. Moreover, the findings may provide a missing link between recombination-dependent mutagenesis in bacteria and yeast, suggesting that both might be stress induced, both maximizing genetic variation when populations could benefit most from diversity.Susan M. RosenbergAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 2, Iss 5 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Susan M. Rosenberg Stress-Induced Loss of Heterozygosity in <italic toggle="yes">Candida</italic>: a Possible Missing Link in the Ability to Evolve
description	ABSTRACT Diploid organisms are buffered against the effects of mutations by carrying two sets of each gene, which allows compensation if one is mutated. But recombination between “mom” and “dad” chromosomes causes loss of heterozygosity (LOH), stretches of “mom-only” or “dad-only” DNA sequence, suddenly revealing effects of mutations accumulated in entire chromosome arms. LOH creates new phenotypes from old mutations, drives cancer development and evolution, and, in a new study by Forche et al., is shown to be induced by stress in Candida albicans [Forche A, et al, mBio 2(4):e00129-11, 2011]. Stress-induced LOH could speed evolution of Candida specifically when it is poorly adapted to its environment. Moreover, the findings may provide a missing link between recombination-dependent mutagenesis in bacteria and yeast, suggesting that both might be stress induced, both maximizing genetic variation when populations could benefit most from diversity.
format	article
author	Susan M. Rosenberg
author_facet	Susan M. Rosenberg
author_sort	Susan M. Rosenberg
title	Stress-Induced Loss of Heterozygosity in <italic toggle="yes">Candida</italic>: a Possible Missing Link in the Ability to Evolve
title_short	Stress-Induced Loss of Heterozygosity in <italic toggle="yes">Candida</italic>: a Possible Missing Link in the Ability to Evolve
title_full	Stress-Induced Loss of Heterozygosity in <italic toggle="yes">Candida</italic>: a Possible Missing Link in the Ability to Evolve
title_fullStr	Stress-Induced Loss of Heterozygosity in <italic toggle="yes">Candida</italic>: a Possible Missing Link in the Ability to Evolve
title_full_unstemmed	Stress-Induced Loss of Heterozygosity in <italic toggle="yes">Candida</italic>: a Possible Missing Link in the Ability to Evolve
title_sort	stress-induced loss of heterozygosity in <italic toggle="yes">candida</italic>: a possible missing link in the ability to evolve
publisher	American Society for Microbiology
publishDate	2011
url	https://doaj.org/article/f41bf30533f04a5693dab78556c01e75
work_keys_str_mv	AT susanmrosenberg stressinducedlossofheterozygosityinitalictoggleyescandidaitalicapossiblemissinglinkintheabilitytoevolve
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Stress-Induced Loss of Heterozygosity in <italic toggle="yes">Candida</italic>: a Possible Missing Link in the Ability to Evolve

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