Trial-level factors affecting accrual and completion of oncology clinical trials: A systematic review

Background: Cancer is the second-leading cause of death in the United States. Clinical trials translate basic science discoveries into treatments needed by cancer patients. Inadequate accrual of trial participants is one of the most significant barriers to the completion of oncology clinical trials....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cherie L. Hauck, Teresa J. Kelechi, Kathleen B. Cartmell, Martina Mueller
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Clinical trial Oncology Cancer Enrollment Accrual Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f41cc4ebcfb94631a01491f5ddab614d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f41cc4ebcfb94631a01491f5ddab614d
record_format	dspace
spelling	oai:doaj.org-article:f41cc4ebcfb94631a01491f5ddab614d2021-11-04T04:34:30ZTrial-level factors affecting accrual and completion of oncology clinical trials: A systematic review2451-865410.1016/j.conctc.2021.100843https://doaj.org/article/f41cc4ebcfb94631a01491f5ddab614d2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2451865421001435https://doaj.org/toc/2451-8654Background: Cancer is the second-leading cause of death in the United States. Clinical trials translate basic science discoveries into treatments needed by cancer patients. Inadequate accrual of trial participants is one of the most significant barriers to the completion of oncology clinical trials. Objective: The purpose of this study was to investigate trial-level factors that affect accrual and/or completion of oncology clinical trials, identify gaps in the literature, and indicate opportunities for future research. Design: A systematic review of the literature on trial-level factors that affect accrual and/or completion of oncology clinical trials was performed. Searches in PubMed and Scopus identified 6582 studies. Based on eligibility criteria, 16 studies were selected for the review. Results were analyzed according to the following: a) background factors, b) disease-related, c) treatment-related, and d) trial design. Results: Background factors that were investigated in relation to oncology clinical trial accrual and/or completion included sponsor, number and location of participating institutions, competing trials, time of trial opening, and fast-track status. Disease-related factors included the annual incidence and type(s) of targeted cancer. Several types of treatment such as drugs, radiation and surgery were examined in the studies. Trial design factors included trial development time, eligibility criteria, randomization, sample size, trial phase, placebo use, and required protocol procedures and their timing. Conclusion: With low patient participation rates in oncology clinical trials that hold promise for future treatments, it is imperative that trial-level factors affecting accrual be identified and addressed to facilitate the completion of trials.Cherie L. HauckTeresa J. KelechiKathleen B. CartmellMartina MuellerElsevierarticleClinical trialOncologyCancerEnrollmentAccrualMedicine (General)R5-920ENContemporary Clinical Trials Communications, Vol 24, Iss , Pp 100843- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Clinical trial Oncology Cancer Enrollment Accrual Medicine (General) R5-920
spellingShingle	Clinical trial Oncology Cancer Enrollment Accrual Medicine (General) R5-920 Cherie L. Hauck Teresa J. Kelechi Kathleen B. Cartmell Martina Mueller Trial-level factors affecting accrual and completion of oncology clinical trials: A systematic review
description	Background: Cancer is the second-leading cause of death in the United States. Clinical trials translate basic science discoveries into treatments needed by cancer patients. Inadequate accrual of trial participants is one of the most significant barriers to the completion of oncology clinical trials. Objective: The purpose of this study was to investigate trial-level factors that affect accrual and/or completion of oncology clinical trials, identify gaps in the literature, and indicate opportunities for future research. Design: A systematic review of the literature on trial-level factors that affect accrual and/or completion of oncology clinical trials was performed. Searches in PubMed and Scopus identified 6582 studies. Based on eligibility criteria, 16 studies were selected for the review. Results were analyzed according to the following: a) background factors, b) disease-related, c) treatment-related, and d) trial design. Results: Background factors that were investigated in relation to oncology clinical trial accrual and/or completion included sponsor, number and location of participating institutions, competing trials, time of trial opening, and fast-track status. Disease-related factors included the annual incidence and type(s) of targeted cancer. Several types of treatment such as drugs, radiation and surgery were examined in the studies. Trial design factors included trial development time, eligibility criteria, randomization, sample size, trial phase, placebo use, and required protocol procedures and their timing. Conclusion: With low patient participation rates in oncology clinical trials that hold promise for future treatments, it is imperative that trial-level factors affecting accrual be identified and addressed to facilitate the completion of trials.
format	article
author	Cherie L. Hauck Teresa J. Kelechi Kathleen B. Cartmell Martina Mueller
author_facet	Cherie L. Hauck Teresa J. Kelechi Kathleen B. Cartmell Martina Mueller
author_sort	Cherie L. Hauck
title	Trial-level factors affecting accrual and completion of oncology clinical trials: A systematic review
title_short	Trial-level factors affecting accrual and completion of oncology clinical trials: A systematic review
title_full	Trial-level factors affecting accrual and completion of oncology clinical trials: A systematic review
title_fullStr	Trial-level factors affecting accrual and completion of oncology clinical trials: A systematic review
title_full_unstemmed	Trial-level factors affecting accrual and completion of oncology clinical trials: A systematic review
title_sort	trial-level factors affecting accrual and completion of oncology clinical trials: a systematic review
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f41cc4ebcfb94631a01491f5ddab614d
work_keys_str_mv	AT cherielhauck triallevelfactorsaffectingaccrualandcompletionofoncologyclinicaltrialsasystematicreview AT teresajkelechi triallevelfactorsaffectingaccrualandcompletionofoncologyclinicaltrialsasystematicreview AT kathleenbcartmell triallevelfactorsaffectingaccrualandcompletionofoncologyclinicaltrialsasystematicreview AT martinamueller triallevelfactorsaffectingaccrualandcompletionofoncologyclinicaltrialsasystematicreview
_version_	1718445308217655296

Trial-level factors affecting accrual and completion of oncology clinical trials: A systematic review

Ejemplares similares