CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study

Abstract C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wayne Huey-Herng Sheu, Wen-Chang Wang, Kwan-Dun Wu, Chih-Tsueng He, Chii-Min Hwu, Thomas Quertermous, Wan-Shan Hsieh, Wen-Jane Lee, Chih-Tai Ting, Yii-Der I. Chen, Chao A. Hsiung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f41d5e5a430f44649956e9f1f6041ec5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f41d5e5a430f44649956e9f1f6041ec5
record_format	dspace
spelling	oai:doaj.org-article:f41d5e5a430f44649956e9f1f6041ec52021-12-02T12:32:51ZCRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study10.1038/s41598-017-08696-22045-2322https://doaj.org/article/f41d5e5a430f44649956e9f1f6041ec52017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08696-2https://doaj.org/toc/2045-2322Abstract C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) to investigate associations between CRP polymorphisms, circulating CRP, diabetes, and glucose levels. Five single-nucleotide polymorphisms were analyzed: rs3093059, rs2794521, rs1417938, rs1800947, and rs1205. The generalized estimating equation approach was used to deal with correlated data within families. CRP level was positively correlated with diabetes prevalence and levels of fasting and 2-hour glucose (each P < 0.008). Alleles C at rs3093059 and G at rs1205 were associated with elevated CRP level (each P < 1.2 × 10−6). Allele C at rs3093059 was associated with fasting glucose (β = 0.20, P = 0.045) and G at rs1205 was associated with 2-hour glucose (β = 0.46, P = 0.00090) post oral glucose tolerance test, but only the latter passed Bonferroni correction. No polymorphism was associated with diabetes. Since 2-hour glucose is an indicator of glucose tolerance, this study indicated CRP gene is associated with glucose intolerance.Wayne Huey-Herng SheuWen-Chang WangKwan-Dun WuChih-Tsueng HeChii-Min HwuThomas QuertermousWan-Shan HsiehWen-Jane LeeChih-Tai TingYii-Der I. ChenChao A. HsiungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wayne Huey-Herng Sheu Wen-Chang Wang Kwan-Dun Wu Chih-Tsueng He Chii-Min Hwu Thomas Quertermous Wan-Shan Hsieh Wen-Jane Lee Chih-Tai Ting Yii-Der I. Chen Chao A. Hsiung CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study
description	Abstract C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) to investigate associations between CRP polymorphisms, circulating CRP, diabetes, and glucose levels. Five single-nucleotide polymorphisms were analyzed: rs3093059, rs2794521, rs1417938, rs1800947, and rs1205. The generalized estimating equation approach was used to deal with correlated data within families. CRP level was positively correlated with diabetes prevalence and levels of fasting and 2-hour glucose (each P < 0.008). Alleles C at rs3093059 and G at rs1205 were associated with elevated CRP level (each P < 1.2 × 10−6). Allele C at rs3093059 was associated with fasting glucose (β = 0.20, P = 0.045) and G at rs1205 was associated with 2-hour glucose (β = 0.46, P = 0.00090) post oral glucose tolerance test, but only the latter passed Bonferroni correction. No polymorphism was associated with diabetes. Since 2-hour glucose is an indicator of glucose tolerance, this study indicated CRP gene is associated with glucose intolerance.
format	article
author	Wayne Huey-Herng Sheu Wen-Chang Wang Kwan-Dun Wu Chih-Tsueng He Chii-Min Hwu Thomas Quertermous Wan-Shan Hsieh Wen-Jane Lee Chih-Tai Ting Yii-Der I. Chen Chao A. Hsiung
author_facet	Wayne Huey-Herng Sheu Wen-Chang Wang Kwan-Dun Wu Chih-Tsueng He Chii-Min Hwu Thomas Quertermous Wan-Shan Hsieh Wen-Jane Lee Chih-Tai Ting Yii-Der I. Chen Chao A. Hsiung
author_sort	Wayne Huey-Herng Sheu
title	CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study
title_short	CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study
title_full	CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study
title_fullStr	CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study
title_full_unstemmed	CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study
title_sort	crp-level-associated polymorphism rs1205 within the crp gene is associated with 2-hour glucose level: the sapphire study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f41d5e5a430f44649956e9f1f6041ec5
work_keys_str_mv	AT waynehueyherngsheu crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT wenchangwang crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT kwandunwu crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT chihtsuenghe crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT chiiminhwu crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT thomasquertermous crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT wanshanhsieh crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT wenjanelee crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT chihtaiting crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT yiiderichen crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy AT chaoahsiung crplevelassociatedpolymorphismrs1205withinthecrpgeneisassociatedwith2hourglucoselevelthesapphirestudy
_version_	1718393955082567680

CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study

Ejemplares similares