Production of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium

Production of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium

Lulu Sun,1,* Peiyu Jia,2 Junfeng Zhang,2 Xin Zhang,2 Yiwei Zhang,2 Hong Jiang,1 Wei Jiang,2 Yong Guo2,* 1Department of Anesthesiology and Critical Care Medicine, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 2Department of Anesthesiology...

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Autores principales: Sun L, Jia P, Zhang J, Zhang X, Zhang Y, Jiang H, Jiang W, Guo Y
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
Elderly
Postoperative delirium
Inflammatory cytokines
Cortisol
β-amyloid protein
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/f4216202616646edae3f36eebf125fcf
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spelling oai:doaj.org-article:f4216202616646edae3f36eebf125fcf2021-12-02T01:26:25ZProduction of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium1178-2021https://doaj.org/article/f4216202616646edae3f36eebf125fcf2016-10-01T00:00:00Zhttps://www.dovepress.com/production-of-inflammatory-cytokines-cortisol-and-abeta1-40-in-elderly-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lulu Sun,1,* Peiyu Jia,2 Junfeng Zhang,2 Xin Zhang,2 Yiwei Zhang,2 Hong Jiang,1 Wei Jiang,2 Yong Guo2,* 1Department of Anesthesiology and Critical Care Medicine, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 2Department of Anesthesiology and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China *These authors contributed equally to this work Aim: Pathophysiological disorders after surgery might be related to postoperative delirium (POD). This study was designed to elucidate the pathogenesis of POD in elderly oral cancer patients by determining the perioperative kinetics of inflammatory cytokines, cortisol, and amyloid β1-40 (Aβ1-40).Methods: A total of 257 elderly oral cancer patients who underwent tumor resection surgery were selected. Venous blood was collected prior to surgery (T0), at the end of surgery (T1), and at 12 hours after surgery (T2). During the first three postoperative days, patients were examined using the confusion assessment method twice a day (8 am and 8 pm). Mini-Mental State Examination scores were recorded at T0 and on postoperative days 1, 3, and 7. Ultimately, 56 patients suffering from POD made up the POD group, and 56 patients randomly selected from a cohort of patients without POD were allocated to the no POD (NPOD) group. Subsequently, interleukin-6, C-reactive protein, procalcitonin, cortisol, and Aβ1-40 in plasma from the two groups were measured.Results: The two groups displayed comparable basic characteristics. There were no differences in all tested biomarkers between the two groups at T0. However, after surgery, the biomarker levels displayed distinct patterns between the two groups. The peak levels of all biomarkers were higher in the POD group than in the NPOD group. Conversely, the Mini-Mental State Examination scores after surgery were lower in the POD group than in the no POD group.Conclusion: The boost of inflammatory cytokines, cortisol, and Aβ1-40 after surgery might be involved in POD onset among elderly oral cancer patients. POD was accompanied by progressive cognitive deficiency. Keywords: elderly, postoperative delirium, inflammatory cytokines, cortisol, β-amyloid proteinSun LJia PZhang JZhang XZhang YJiang HJiang WGuo YDove Medical PressarticleElderlyPostoperative deliriumInflammatory cytokinesCortisolβ-amyloid proteinNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2789-2795 (2016)
institution DOAJ
collection DOAJ
language EN
topic Elderly
Postoperative delirium
Inflammatory cytokines
Cortisol
β-amyloid protein
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Elderly
Postoperative delirium
Inflammatory cytokines
Cortisol
β-amyloid protein
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Sun L
Jia P
Zhang J
Zhang X
Zhang Y
Jiang H
Jiang W
Guo Y
Production of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium
description Lulu Sun,1,* Peiyu Jia,2 Junfeng Zhang,2 Xin Zhang,2 Yiwei Zhang,2 Hong Jiang,1 Wei Jiang,2 Yong Guo2,* 1Department of Anesthesiology and Critical Care Medicine, Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 2Department of Anesthesiology and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China *These authors contributed equally to this work Aim: Pathophysiological disorders after surgery might be related to postoperative delirium (POD). This study was designed to elucidate the pathogenesis of POD in elderly oral cancer patients by determining the perioperative kinetics of inflammatory cytokines, cortisol, and amyloid β1-40 (Aβ1-40).Methods: A total of 257 elderly oral cancer patients who underwent tumor resection surgery were selected. Venous blood was collected prior to surgery (T0), at the end of surgery (T1), and at 12 hours after surgery (T2). During the first three postoperative days, patients were examined using the confusion assessment method twice a day (8 am and 8 pm). Mini-Mental State Examination scores were recorded at T0 and on postoperative days 1, 3, and 7. Ultimately, 56 patients suffering from POD made up the POD group, and 56 patients randomly selected from a cohort of patients without POD were allocated to the no POD (NPOD) group. Subsequently, interleukin-6, C-reactive protein, procalcitonin, cortisol, and Aβ1-40 in plasma from the two groups were measured.Results: The two groups displayed comparable basic characteristics. There were no differences in all tested biomarkers between the two groups at T0. However, after surgery, the biomarker levels displayed distinct patterns between the two groups. The peak levels of all biomarkers were higher in the POD group than in the NPOD group. Conversely, the Mini-Mental State Examination scores after surgery were lower in the POD group than in the no POD group.Conclusion: The boost of inflammatory cytokines, cortisol, and Aβ1-40 after surgery might be involved in POD onset among elderly oral cancer patients. POD was accompanied by progressive cognitive deficiency. Keywords: elderly, postoperative delirium, inflammatory cytokines, cortisol, β-amyloid protein
format article
author Sun L
Jia P
Zhang J
Zhang X
Zhang Y
Jiang H
Jiang W
Guo Y
author_facet Sun L
Jia P
Zhang J
Zhang X
Zhang Y
Jiang H
Jiang W
Guo Y
author_sort Sun L
title Production of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium
title_short Production of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium
title_full Production of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium
title_fullStr Production of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium
title_full_unstemmed Production of inflammatory cytokines, cortisol, and Aβ1-40 in elderly oral cancer patients with postoperative delirium
title_sort production of inflammatory cytokines, cortisol, and aβ1-40 in elderly oral cancer patients with postoperative delirium
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/f4216202616646edae3f36eebf125fcf
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