Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentia...

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Autores principales:	Lucia Cabal-Hierro, Peter van Galen, Miguel A. Prado, Kelly J. Higby, Katsuhiro Togami, Cody T. Mowery, Joao A. Paulo, Yingtian Xie, Paloma Cejas, Takashi Furusawa, Michael Bustin, Henry W. Long, David B. Sykes, Steven P. Gygi, Daniel Finley, Bradley E. Bernstein, Andrew A. Lane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f424d9b406fb49f7a429fe6474f60a2d
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spelling	oai:doaj.org-article:f424d9b406fb49f7a429fe6474f60a2d2021-12-02T15:33:52ZChromatin accessibility promotes hematopoietic and leukemia stem cell activity10.1038/s41467-020-15221-z2041-1723https://doaj.org/article/f424d9b406fb49f7a429fe6474f60a2d2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15221-zhttps://doaj.org/toc/2041-1723Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentiation.Lucia Cabal-HierroPeter van GalenMiguel A. PradoKelly J. HigbyKatsuhiro TogamiCody T. MoweryJoao A. PauloYingtian XiePaloma CejasTakashi FurusawaMichael BustinHenry W. LongDavid B. SykesSteven P. GygiDaniel FinleyBradley E. BernsteinAndrew A. LaneNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucia Cabal-Hierro Peter van Galen Miguel A. Prado Kelly J. Higby Katsuhiro Togami Cody T. Mowery Joao A. Paulo Yingtian Xie Paloma Cejas Takashi Furusawa Michael Bustin Henry W. Long David B. Sykes Steven P. Gygi Daniel Finley Bradley E. Bernstein Andrew A. Lane Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
description	Chromatin accessibility is a key mediator of gene expression and mutations in chromatin modifiers are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which is frequently mutated by amplification in leukemias - acts by blocking myeloid differentiation.
format	article
author	Lucia Cabal-Hierro Peter van Galen Miguel A. Prado Kelly J. Higby Katsuhiro Togami Cody T. Mowery Joao A. Paulo Yingtian Xie Paloma Cejas Takashi Furusawa Michael Bustin Henry W. Long David B. Sykes Steven P. Gygi Daniel Finley Bradley E. Bernstein Andrew A. Lane
author_facet	Lucia Cabal-Hierro Peter van Galen Miguel A. Prado Kelly J. Higby Katsuhiro Togami Cody T. Mowery Joao A. Paulo Yingtian Xie Paloma Cejas Takashi Furusawa Michael Bustin Henry W. Long David B. Sykes Steven P. Gygi Daniel Finley Bradley E. Bernstein Andrew A. Lane
author_sort	Lucia Cabal-Hierro
title	Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_short	Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_full	Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_fullStr	Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_full_unstemmed	Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
title_sort	chromatin accessibility promotes hematopoietic and leukemia stem cell activity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f424d9b406fb49f7a429fe6474f60a2d
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Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

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