EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.

<h4>Background</h4>The primordial organization of the metazoan body is achieved during gastrulation by the establishment of the germ layers. Adhesion differences between ectoderm, mesoderm, and endoderm cells could in principle be sufficient to maintain germ layer integrity and prevent i...

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Autores principales:	Nazanin Rohani, Laura Canty, Olivia Luu, François Fagotto, Rudolf Winklbauer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f425740e81d6470aa9b67d5d791af3d0
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spelling	oai:doaj.org-article:f425740e81d6470aa9b67d5d791af3d02021-11-18T05:36:18ZEphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.1544-91731545-788510.1371/journal.pbio.1000597https://doaj.org/article/f425740e81d6470aa9b67d5d791af3d02011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21390298/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885<h4>Background</h4>The primordial organization of the metazoan body is achieved during gastrulation by the establishment of the germ layers. Adhesion differences between ectoderm, mesoderm, and endoderm cells could in principle be sufficient to maintain germ layer integrity and prevent intermixing. However, in organisms as diverse as fly, fish, or amphibian, the ectoderm-mesoderm boundary not only keeps these germ layers separated, but the ectoderm also serves as substratum for mesoderm migration, and the boundary must be compatible with repeated cell attachment and detachment.<h4>Principal findings</h4>We show that localized detachment resulting from contact-induced signals at the boundary is at the core of ectoderm-mesoderm segregation. Cells alternate between adhesion and detachment, and detachment requires ephrinB/EphB signaling. Multiple ephrinB ligands and EphB receptors are expressed on each side of the boundary, and tissue separation depends on forward signaling across the boundary in both directions, involving partially redundant ligands and receptors and activation of Rac and RhoA.<h4>Conclusion</h4>This mechanism differs from a simple differential adhesion process of germ layer formation. Instead, it involves localized responses to signals exchanged at the tissue boundary and an attachment/detachment cycle which allows for cell migration across a cellular substratum.Nazanin RohaniLaura CantyOlivia LuuFrançois FagottoRudolf WinklbauerPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 9, Iss 3, p e1000597 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nazanin Rohani Laura Canty Olivia Luu François Fagotto Rudolf Winklbauer EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.
description	<h4>Background</h4>The primordial organization of the metazoan body is achieved during gastrulation by the establishment of the germ layers. Adhesion differences between ectoderm, mesoderm, and endoderm cells could in principle be sufficient to maintain germ layer integrity and prevent intermixing. However, in organisms as diverse as fly, fish, or amphibian, the ectoderm-mesoderm boundary not only keeps these germ layers separated, but the ectoderm also serves as substratum for mesoderm migration, and the boundary must be compatible with repeated cell attachment and detachment.<h4>Principal findings</h4>We show that localized detachment resulting from contact-induced signals at the boundary is at the core of ectoderm-mesoderm segregation. Cells alternate between adhesion and detachment, and detachment requires ephrinB/EphB signaling. Multiple ephrinB ligands and EphB receptors are expressed on each side of the boundary, and tissue separation depends on forward signaling across the boundary in both directions, involving partially redundant ligands and receptors and activation of Rac and RhoA.<h4>Conclusion</h4>This mechanism differs from a simple differential adhesion process of germ layer formation. Instead, it involves localized responses to signals exchanged at the tissue boundary and an attachment/detachment cycle which allows for cell migration across a cellular substratum.
format	article
author	Nazanin Rohani Laura Canty Olivia Luu François Fagotto Rudolf Winklbauer
author_facet	Nazanin Rohani Laura Canty Olivia Luu François Fagotto Rudolf Winklbauer
author_sort	Nazanin Rohani
title	EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.
title_short	EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.
title_full	EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.
title_fullStr	EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.
title_full_unstemmed	EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.
title_sort	ephrinb/ephb signaling controls embryonic germ layer separation by contact-induced cell detachment.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/f425740e81d6470aa9b67d5d791af3d0
work_keys_str_mv	AT nazaninrohani ephrinbephbsignalingcontrolsembryonicgermlayerseparationbycontactinducedcelldetachment AT lauracanty ephrinbephbsignalingcontrolsembryonicgermlayerseparationbycontactinducedcelldetachment AT olivialuu ephrinbephbsignalingcontrolsembryonicgermlayerseparationbycontactinducedcelldetachment AT francoisfagotto ephrinbephbsignalingcontrolsembryonicgermlayerseparationbycontactinducedcelldetachment AT rudolfwinklbauer ephrinbephbsignalingcontrolsembryonicgermlayerseparationbycontactinducedcelldetachment
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EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment.

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