Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey

This study was carried out to determine polymorphisms of four genes in South Anatolian Red (SAR) and East Anatolian Red (EAR) indigenous cattle breeds in Turkey. Single nucleotide polymorphisms (SNPs) monitored in this study are Y581S in ATP binding cassette sub family G member 2 (ABCG2) gene, c.189...

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Autores principales:	Ateş Atila, Türkay Hoştürk Gülhan, Akiş Iraz, Esen Gürsel Feraye, Yardibi Hasret, Öztabak Kemal
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	abcg2 gene east anatolian red gene polymorphism olr1 gene ppargc1a gene south anatolian red Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/f429d41fc3fc4f17a38763f224426eb1
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spelling	oai:doaj.org-article:f429d41fc3fc4f17a38763f224426eb12021-11-17T21:27:52ZGenotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey1820-744810.2478/acve-2014-0008https://doaj.org/article/f429d41fc3fc4f17a38763f224426eb12014-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0008https://doaj.org/toc/1820-7448This study was carried out to determine polymorphisms of four genes in South Anatolian Red (SAR) and East Anatolian Red (EAR) indigenous cattle breeds in Turkey. Single nucleotide polymorphisms (SNPs) monitored in this study are Y581S in ATP binding cassette sub family G member 2 (ABCG2) gene, c.1892T>C and c.3359A>C in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene and g.8232C>A in oxidized low-density lipoprotein receptor 1 (OLR1) gene. The frequency of the ancestral allele A of the ABCG2 gene Y581S polymorphism was found to be very high (SAR: 0.63; EAR: 0.64) in both cattle breeds. The CC genotypes of PPARGC1A gene c.1892T>C (SAR: 0.65; EAR: 0.80) and OLR1 gene g.8232C>A polymorphisms (SAR: 0.82; EAR: 0.86), which are associated with high milk fat percentage, had higher frequencies than those of the other genotypes. In conclusion, we might suggest that the allele distribution of the ABCG2 gene Y581S polymorphism can be the evidence indicating autosomal gene flow from zebu cattle to SAR and EAR cattle breeds.Ateş AtilaTürkay Hoştürk GülhanAkiş IrazEsen Gürsel FerayeYardibi HasretÖztabak KemalSciendoarticleabcg2 geneeast anatolian redgene polymorphismolr1 geneppargc1a genesouth anatolian redVeterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 1, Pp 73-80 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	abcg2 gene east anatolian red gene polymorphism olr1 gene ppargc1a gene south anatolian red Veterinary medicine SF600-1100
spellingShingle	abcg2 gene east anatolian red gene polymorphism olr1 gene ppargc1a gene south anatolian red Veterinary medicine SF600-1100 Ateş Atila Türkay Hoştürk Gülhan Akiş Iraz Esen Gürsel Feraye Yardibi Hasret Öztabak Kemal Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey
description	This study was carried out to determine polymorphisms of four genes in South Anatolian Red (SAR) and East Anatolian Red (EAR) indigenous cattle breeds in Turkey. Single nucleotide polymorphisms (SNPs) monitored in this study are Y581S in ATP binding cassette sub family G member 2 (ABCG2) gene, c.1892T>C and c.3359A>C in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene and g.8232C>A in oxidized low-density lipoprotein receptor 1 (OLR1) gene. The frequency of the ancestral allele A of the ABCG2 gene Y581S polymorphism was found to be very high (SAR: 0.63; EAR: 0.64) in both cattle breeds. The CC genotypes of PPARGC1A gene c.1892T>C (SAR: 0.65; EAR: 0.80) and OLR1 gene g.8232C>A polymorphisms (SAR: 0.82; EAR: 0.86), which are associated with high milk fat percentage, had higher frequencies than those of the other genotypes. In conclusion, we might suggest that the allele distribution of the ABCG2 gene Y581S polymorphism can be the evidence indicating autosomal gene flow from zebu cattle to SAR and EAR cattle breeds.
format	article
author	Ateş Atila Türkay Hoştürk Gülhan Akiş Iraz Esen Gürsel Feraye Yardibi Hasret Öztabak Kemal
author_facet	Ateş Atila Türkay Hoştürk Gülhan Akiş Iraz Esen Gürsel Feraye Yardibi Hasret Öztabak Kemal
author_sort	Ateş Atila
title	Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey
title_short	Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey
title_full	Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey
title_fullStr	Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey
title_full_unstemmed	Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey
title_sort	genotype and allele frequencies of polymorphisms in abcg2, ppargc1a and olr1 genes in indigenous cattle breeds in turkey
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/f429d41fc3fc4f17a38763f224426eb1
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Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey

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