Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

Parkinson’s disease (PD) is a neurodegenerative disease in which the neurotransmitter dopamine (DA) depletes due to the progressive loss of nigrostriatal neurons. Therefore, DA measurement might be a useful diagnostic tool for targeting the early stages of PD, as well as helping to optimize DA repla...

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Autores principales:	Małgorzata Kujawska, Sheetal K. Bhardwaj, Yogendra Kumar Mishra, Ajeet Kaushik
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dopamine Parkinson’s disease graphene point-of-care biosensing Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/f42b3bfd688a409680be6a6efb49312b
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spelling	oai:doaj.org-article:f42b3bfd688a409680be6a6efb49312b2021-11-25T16:55:19ZUsing Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics10.3390/bios111104332079-6374https://doaj.org/article/f42b3bfd688a409680be6a6efb49312b2021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/433https://doaj.org/toc/2079-6374Parkinson’s disease (PD) is a neurodegenerative disease in which the neurotransmitter dopamine (DA) depletes due to the progressive loss of nigrostriatal neurons. Therefore, DA measurement might be a useful diagnostic tool for targeting the early stages of PD, as well as helping to optimize DA replacement therapy. Moreover, DA sensing appears to be a useful analytical tool in complex biological systems in PD studies. To support the feasibility of this concept, this mini-review explores the currently developed graphene-based biosensors dedicated to DA detection. We discuss various graphene modifications designed for high-performance DA sensing electrodes alongside their analytical performances and interference studies, which we listed based on their limit of detection in biological samples. Moreover, graphene-based biosensors for optical DA detection are also presented herein. Regarding clinical relevance, we explored the development trends of graphene-based electrochemical sensing of DA as they relate to point-of-care testing suitable for the site-of-location diagnostics needed for personalized PD management. In this field, the biosensors are developed into smartphone-connected systems for intelligent disease management. However, we highlighted that the focus should be on the clinical utility rather than analytical and technical performance.Małgorzata KujawskaSheetal K. BhardwajYogendra Kumar MishraAjeet KaushikMDPI AGarticledopamineParkinson’s diseasegraphenepoint-of-carebiosensingBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 433, p 433 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dopamine Parkinson’s disease graphene point-of-care biosensing Biotechnology TP248.13-248.65
spellingShingle	dopamine Parkinson’s disease graphene point-of-care biosensing Biotechnology TP248.13-248.65 Małgorzata Kujawska Sheetal K. Bhardwaj Yogendra Kumar Mishra Ajeet Kaushik Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics
description	Parkinson’s disease (PD) is a neurodegenerative disease in which the neurotransmitter dopamine (DA) depletes due to the progressive loss of nigrostriatal neurons. Therefore, DA measurement might be a useful diagnostic tool for targeting the early stages of PD, as well as helping to optimize DA replacement therapy. Moreover, DA sensing appears to be a useful analytical tool in complex biological systems in PD studies. To support the feasibility of this concept, this mini-review explores the currently developed graphene-based biosensors dedicated to DA detection. We discuss various graphene modifications designed for high-performance DA sensing electrodes alongside their analytical performances and interference studies, which we listed based on their limit of detection in biological samples. Moreover, graphene-based biosensors for optical DA detection are also presented herein. Regarding clinical relevance, we explored the development trends of graphene-based electrochemical sensing of DA as they relate to point-of-care testing suitable for the site-of-location diagnostics needed for personalized PD management. In this field, the biosensors are developed into smartphone-connected systems for intelligent disease management. However, we highlighted that the focus should be on the clinical utility rather than analytical and technical performance.
format	article
author	Małgorzata Kujawska Sheetal K. Bhardwaj Yogendra Kumar Mishra Ajeet Kaushik
author_facet	Małgorzata Kujawska Sheetal K. Bhardwaj Yogendra Kumar Mishra Ajeet Kaushik
author_sort	Małgorzata Kujawska
title	Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics
title_short	Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics
title_full	Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics
title_fullStr	Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics
title_full_unstemmed	Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics
title_sort	using graphene-based biosensors to detect dopamine for efficient parkinson’s disease diagnostics
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f42b3bfd688a409680be6a6efb49312b
work_keys_str_mv	AT małgorzatakujawska usinggraphenebasedbiosensorstodetectdopamineforefficientparkinsonsdiseasediagnostics AT sheetalkbhardwaj usinggraphenebasedbiosensorstodetectdopamineforefficientparkinsonsdiseasediagnostics AT yogendrakumarmishra usinggraphenebasedbiosensorstodetectdopamineforefficientparkinsonsdiseasediagnostics AT ajeetkaushik usinggraphenebasedbiosensorstodetectdopamineforefficientparkinsonsdiseasediagnostics
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Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

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