ADHFE1 is a correlative factor of patient survival in cancer

Alcohol dehydrogenase iron containing 1 (ADHFE1) encodes a hydroxyacid-oxoacid transhydrogenase participating in multiple biological processes. The role of ADHFE1 in cancer has not been fully uncovered. Herein, we performed data analysis to investigate the expression of ADHFE1 and the underlying reg...

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Autores principales:	Chen Qi, Wu Qiyan, Peng Yaojun
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	adhfe1 cancer biomarker bioinformatics analysis dna methylation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f431e3192df94cfe9ed7a3326c9ee4e4
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spelling	oai:doaj.org-article:f431e3192df94cfe9ed7a3326c9ee4e42021-12-05T14:10:41ZADHFE1 is a correlative factor of patient survival in cancer2391-541210.1515/biol-2021-0065https://doaj.org/article/f431e3192df94cfe9ed7a3326c9ee4e42021-06-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0065https://doaj.org/toc/2391-5412Alcohol dehydrogenase iron containing 1 (ADHFE1) encodes a hydroxyacid-oxoacid transhydrogenase participating in multiple biological processes. The role of ADHFE1 in cancer has not been fully uncovered. Herein, we performed data analysis to investigate the expression of ADHFE1 and the underlying regulatory mechanisms, its relationship with cancer patients’ survival, and the relevant pathways in cancer. A range of recognized, web-available databases and bioinformatics tools were used in this in silico study. We found that ADHFE1 was frequently downregulated and hypermethylated in various cancer cell lines and tissue samples. High expression of ADHFE1 was positively associated with favorable patient prognosis in breast, colon, and gastric cancers. Pathway analysis revealed its potential role in cancer-related biological processes, including energy metabolism, DNA replication, and cell cycle regulation. AHDFE1 mRNA expression and DNA methylation can potentially be used as diagnostic markers in cancer and might be of great value in predicting the survival of patients with cancer.Chen QiWu QiyanPeng YaojunDe Gruyterarticleadhfe1cancer biomarkerbioinformatics analysisdna methylationBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 571-582 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adhfe1 cancer biomarker bioinformatics analysis dna methylation Biology (General) QH301-705.5
spellingShingle	adhfe1 cancer biomarker bioinformatics analysis dna methylation Biology (General) QH301-705.5 Chen Qi Wu Qiyan Peng Yaojun ADHFE1 is a correlative factor of patient survival in cancer
description	Alcohol dehydrogenase iron containing 1 (ADHFE1) encodes a hydroxyacid-oxoacid transhydrogenase participating in multiple biological processes. The role of ADHFE1 in cancer has not been fully uncovered. Herein, we performed data analysis to investigate the expression of ADHFE1 and the underlying regulatory mechanisms, its relationship with cancer patients’ survival, and the relevant pathways in cancer. A range of recognized, web-available databases and bioinformatics tools were used in this in silico study. We found that ADHFE1 was frequently downregulated and hypermethylated in various cancer cell lines and tissue samples. High expression of ADHFE1 was positively associated with favorable patient prognosis in breast, colon, and gastric cancers. Pathway analysis revealed its potential role in cancer-related biological processes, including energy metabolism, DNA replication, and cell cycle regulation. AHDFE1 mRNA expression and DNA methylation can potentially be used as diagnostic markers in cancer and might be of great value in predicting the survival of patients with cancer.
format	article
author	Chen Qi Wu Qiyan Peng Yaojun
author_facet	Chen Qi Wu Qiyan Peng Yaojun
author_sort	Chen Qi
title	ADHFE1 is a correlative factor of patient survival in cancer
title_short	ADHFE1 is a correlative factor of patient survival in cancer
title_full	ADHFE1 is a correlative factor of patient survival in cancer
title_fullStr	ADHFE1 is a correlative factor of patient survival in cancer
title_full_unstemmed	ADHFE1 is a correlative factor of patient survival in cancer
title_sort	adhfe1 is a correlative factor of patient survival in cancer
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/f431e3192df94cfe9ed7a3326c9ee4e4
work_keys_str_mv	AT chenqi adhfe1isacorrelativefactorofpatientsurvivalincancer AT wuqiyan adhfe1isacorrelativefactorofpatientsurvivalincancer AT pengyaojun adhfe1isacorrelativefactorofpatientsurvivalincancer
_version_	1718371874606415872

ADHFE1 is a correlative factor of patient survival in cancer

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