Antiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study

Abstract We evaluated the effect of SSRI treatment on platelet aggregation in patients with ischaemic stroke and included patients from the randomized double-blind controlled study of citalopram in acute ischaemic stroke (TALOS). Patients on clopidogrel were included 6 months after acute ischaemic s...

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Autores principales:	Kristian Lundsgaard Kraglund, Janne Kaergaard Mortensen, Søren Paaske Johnsen, Grethe Andersen, Erik Lerkevang Grove
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f434cb39c17e4a90be2bbcf4822ac0d1
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spelling	oai:doaj.org-article:f434cb39c17e4a90be2bbcf4822ac0d12021-12-02T13:35:11ZAntiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study10.1038/s41598-019-56487-82045-2322https://doaj.org/article/f434cb39c17e4a90be2bbcf4822ac0d12019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56487-8https://doaj.org/toc/2045-2322Abstract We evaluated the effect of SSRI treatment on platelet aggregation in patients with ischaemic stroke and included patients from the randomized double-blind controlled study of citalopram in acute ischaemic stroke (TALOS). Patients on clopidogrel were included 6 months after acute ischaemic stroke. Platelet parameters, including P2Y12 platelet reactivity using the VerifyNow System, were measured at the last day of study treatment and repeated after a 14-day wash-out period. A total of 60 patients were included (n = 32 randomized to citalopram). Platelet aggregation levels did not differ between the citalopram group (mean 116, 95% CI 89 to 143) and the placebo group (mean 136, 95% CI 109 to 163) (On-treatment, p = 0.14). Similarly, there was no significant change in platelet aggregation in the citalopram group from on-treatment to post-treatment (mean difference 2.0; 95% CI −18 to 14). Platelet count, size and turnover were not affected by SSRI treatment. In conclusion, SSRI therapy did not lead to statistically significant inhibition of platelet aggregation in ischaemic stroke patients treated with clopidogrel.Kristian Lundsgaard KraglundJanne Kaergaard MortensenSøren Paaske JohnsenGrethe AndersenErik Lerkevang GroveNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-4 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kristian Lundsgaard Kraglund Janne Kaergaard Mortensen Søren Paaske Johnsen Grethe Andersen Erik Lerkevang Grove Antiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study
description	Abstract We evaluated the effect of SSRI treatment on platelet aggregation in patients with ischaemic stroke and included patients from the randomized double-blind controlled study of citalopram in acute ischaemic stroke (TALOS). Patients on clopidogrel were included 6 months after acute ischaemic stroke. Platelet parameters, including P2Y12 platelet reactivity using the VerifyNow System, were measured at the last day of study treatment and repeated after a 14-day wash-out period. A total of 60 patients were included (n = 32 randomized to citalopram). Platelet aggregation levels did not differ between the citalopram group (mean 116, 95% CI 89 to 143) and the placebo group (mean 136, 95% CI 109 to 163) (On-treatment, p = 0.14). Similarly, there was no significant change in platelet aggregation in the citalopram group from on-treatment to post-treatment (mean difference 2.0; 95% CI −18 to 14). Platelet count, size and turnover were not affected by SSRI treatment. In conclusion, SSRI therapy did not lead to statistically significant inhibition of platelet aggregation in ischaemic stroke patients treated with clopidogrel.
format	article
author	Kristian Lundsgaard Kraglund Janne Kaergaard Mortensen Søren Paaske Johnsen Grethe Andersen Erik Lerkevang Grove
author_facet	Kristian Lundsgaard Kraglund Janne Kaergaard Mortensen Søren Paaske Johnsen Grethe Andersen Erik Lerkevang Grove
author_sort	Kristian Lundsgaard Kraglund
title	Antiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study
title_short	Antiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study
title_full	Antiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study
title_fullStr	Antiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study
title_full_unstemmed	Antiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study
title_sort	antiplatelet effects of citalopram in patients with ischaemic stroke: a randomized, placebo-controlled, double-blind study
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f434cb39c17e4a90be2bbcf4822ac0d1
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Antiplatelet effects of citalopram in patients with ischaemic stroke: A randomized, placebo-controlled, double-blind study

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