Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.

<h4>Background</h4>The Bolivian northern Altiplano is characterized by a high prevalence of Fasciola hepatica infection. In order to assess the feasibility, safety and efficacy of large-scale administration of triclabendazole as an appropriate public health measure to control morbidity a...

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Autores principales:	Fidel Villegas, René Angles, René Barrientos, Gary Barrios, María Adela Valero, Kamal Hamed, Heiner Grueninger, Steven K Ault, Antonio Montresor, Dirk Engels, Santiago Mas-Coma, Albis Francesco Gabrielli
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/f4359a226765471b81b5a920e38ebc06
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spelling	oai:doaj.org-article:f4359a226765471b81b5a920e38ebc062021-11-18T09:13:56ZAdministration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.1935-27271935-273510.1371/journal.pntd.0001720https://doaj.org/article/f4359a226765471b81b5a920e38ebc062012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22880138/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>The Bolivian northern Altiplano is characterized by a high prevalence of Fasciola hepatica infection. In order to assess the feasibility, safety and efficacy of large-scale administration of triclabendazole as an appropriate public health measure to control morbidity associated with fascioliasis, a pilot intervention was implemented in 2008.<h4>Materials and methods</h4>Schoolchildren from an endemic community were screened for fascioliasis and treated with a single administration of triclabendazole (10 mg/kg). Interviews to assess the occurrence of adverse events were conducted on treatment day, one week later, and one month after treatment. Further parasitological screenings were performed three months after treatment and again two months later (following a further treatment) in order to evaluate the efficacy of the intervention.<h4>Results</h4>Ninety infected children were administered triclabendazole. Adverse events were infrequent and mild. No serious adverse events were reported. Observed cure rates were 77.8% after one treatment and 97.8% after two treatments, while egg reduction rates ranged between 74% and 90.3% after one treatment, and between 84.2% and 99.9% after two treatments. The proportion of high-intensity infections (≥ 400 epg) decreased from 7.8% to 1.1% after one treatment and to 0% after two treatments.<h4>Conclusion</h4>Administration of triclabendazole is a feasible, safe and efficacious public health intervention in an endemic community in the Bolivian Altiplano, suggesting that preventive chemotherapy can be applied to control of fascioliasis. Further investigations are needed to define the most appropriate frequency of treatment.Fidel VillegasRené AnglesRené BarrientosGary BarriosMaría Adela ValeroKamal HamedHeiner GrueningerSteven K AultAntonio MontresorDirk EngelsSantiago Mas-ComaAlbis Francesco GabrielliPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 6, Iss 8, p e1720 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Fidel Villegas René Angles René Barrientos Gary Barrios María Adela Valero Kamal Hamed Heiner Grueninger Steven K Ault Antonio Montresor Dirk Engels Santiago Mas-Coma Albis Francesco Gabrielli Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.
description	<h4>Background</h4>The Bolivian northern Altiplano is characterized by a high prevalence of Fasciola hepatica infection. In order to assess the feasibility, safety and efficacy of large-scale administration of triclabendazole as an appropriate public health measure to control morbidity associated with fascioliasis, a pilot intervention was implemented in 2008.<h4>Materials and methods</h4>Schoolchildren from an endemic community were screened for fascioliasis and treated with a single administration of triclabendazole (10 mg/kg). Interviews to assess the occurrence of adverse events were conducted on treatment day, one week later, and one month after treatment. Further parasitological screenings were performed three months after treatment and again two months later (following a further treatment) in order to evaluate the efficacy of the intervention.<h4>Results</h4>Ninety infected children were administered triclabendazole. Adverse events were infrequent and mild. No serious adverse events were reported. Observed cure rates were 77.8% after one treatment and 97.8% after two treatments, while egg reduction rates ranged between 74% and 90.3% after one treatment, and between 84.2% and 99.9% after two treatments. The proportion of high-intensity infections (≥ 400 epg) decreased from 7.8% to 1.1% after one treatment and to 0% after two treatments.<h4>Conclusion</h4>Administration of triclabendazole is a feasible, safe and efficacious public health intervention in an endemic community in the Bolivian Altiplano, suggesting that preventive chemotherapy can be applied to control of fascioliasis. Further investigations are needed to define the most appropriate frequency of treatment.
format	article
author	Fidel Villegas René Angles René Barrientos Gary Barrios María Adela Valero Kamal Hamed Heiner Grueninger Steven K Ault Antonio Montresor Dirk Engels Santiago Mas-Coma Albis Francesco Gabrielli
author_facet	Fidel Villegas René Angles René Barrientos Gary Barrios María Adela Valero Kamal Hamed Heiner Grueninger Steven K Ault Antonio Montresor Dirk Engels Santiago Mas-Coma Albis Francesco Gabrielli
author_sort	Fidel Villegas
title	Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.
title_short	Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.
title_full	Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.
title_fullStr	Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.
title_full_unstemmed	Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.
title_sort	administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the bolivian altiplano.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/f4359a226765471b81b5a920e38ebc06
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Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.

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