Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels

Abstract Because of the lack of studies focused on the biological implications of extremely low B-type natriuretic peptide (BNP) levels, we investigated whether extremely low BNP levels could be harmful to the cardiovascular system due to compromised cardio-protection. By using cardiac troponin I (c...

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Autores principales:	Satoshi Sugawa, Izuru Masuda, Kiminori Kato, Michihiro Yoshimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f43daa02a3fb4869809028ceebbdfe40
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spelling	oai:doaj.org-article:f43daa02a3fb4869809028ceebbdfe402021-12-02T15:07:57ZIncreased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels10.1038/s41598-018-23441-z2045-2322https://doaj.org/article/f43daa02a3fb4869809028ceebbdfe402018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23441-zhttps://doaj.org/toc/2045-2322Abstract Because of the lack of studies focused on the biological implications of extremely low B-type natriuretic peptide (BNP) levels, we investigated whether extremely low BNP levels could be harmful to the cardiovascular system due to compromised cardio-protection. By using cardiac troponin I (cTnI) as an indicator of cardiovascular disorder, we assessed whether cTnI was inversely associated with BNP in populations with low BNP levels. A total of 2,001 apparently healthy subjects older than 38 years were included in this study. We defined subgroups from this population by limiting the maximum BNP level with cut-off values ranging from 1 through 20 pg/mL and performed covariance structure analyses by comparing log(BNP) with log(cTnI) in each subgroup. The beta values between log(BNP) and log(cTnI) sharply decreased as the BNP cut-off was reduced from 20 pg/mL (beta = 0.04) to 1 pg/mL (beta = −0.29) and became significant when the BNP cut-off levels were lower than 4 pg/mL (p < 0.005). In subgroups with BNP levels lower than 4 pg/mL, elevation in cTnI level was inversely associated with BNP (p < 0.005), which suggests that insufficient BNP may play a pathogenic role in the occurrence of cardiovascular abnormalities.Satoshi SugawaIzuru MasudaKiminori KatoMichihiro YoshimuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Satoshi Sugawa Izuru Masuda Kiminori Kato Michihiro Yoshimura Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels
description	Abstract Because of the lack of studies focused on the biological implications of extremely low B-type natriuretic peptide (BNP) levels, we investigated whether extremely low BNP levels could be harmful to the cardiovascular system due to compromised cardio-protection. By using cardiac troponin I (cTnI) as an indicator of cardiovascular disorder, we assessed whether cTnI was inversely associated with BNP in populations with low BNP levels. A total of 2,001 apparently healthy subjects older than 38 years were included in this study. We defined subgroups from this population by limiting the maximum BNP level with cut-off values ranging from 1 through 20 pg/mL and performed covariance structure analyses by comparing log(BNP) with log(cTnI) in each subgroup. The beta values between log(BNP) and log(cTnI) sharply decreased as the BNP cut-off was reduced from 20 pg/mL (beta = 0.04) to 1 pg/mL (beta = −0.29) and became significant when the BNP cut-off levels were lower than 4 pg/mL (p < 0.005). In subgroups with BNP levels lower than 4 pg/mL, elevation in cTnI level was inversely associated with BNP (p < 0.005), which suggests that insufficient BNP may play a pathogenic role in the occurrence of cardiovascular abnormalities.
format	article
author	Satoshi Sugawa Izuru Masuda Kiminori Kato Michihiro Yoshimura
author_facet	Satoshi Sugawa Izuru Masuda Kiminori Kato Michihiro Yoshimura
author_sort	Satoshi Sugawa
title	Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels
title_short	Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels
title_full	Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels
title_fullStr	Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels
title_full_unstemmed	Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels
title_sort	increased levels of cardiac troponin i in subjects with extremely low b-type natriuretic peptide levels
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f43daa02a3fb4869809028ceebbdfe40
work_keys_str_mv	AT satoshisugawa increasedlevelsofcardiactroponiniinsubjectswithextremelylowbtypenatriureticpeptidelevels AT izurumasuda increasedlevelsofcardiactroponiniinsubjectswithextremelylowbtypenatriureticpeptidelevels AT kiminorikato increasedlevelsofcardiactroponiniinsubjectswithextremelylowbtypenatriureticpeptidelevels AT michihiroyoshimura increasedlevelsofcardiactroponiniinsubjectswithextremelylowbtypenatriureticpeptidelevels
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Increased Levels of Cardiac Troponin I in Subjects with Extremely Low B-type Natriuretic Peptide Levels

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