Novel type of references for weight aligned for onset of puberty – using the QEPS growth model

Abstract Background Growth references are traditionally constructed relative to chronological age, despite inter-individual variations in pubertal timing. A new type of height reference was recently developed allowing growth to be aligned based on onset of pubertal height growth. We here aim to deve...

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Autores principales:	Kerstin Albertsson-Wikland, Aimon Niklasson, Lars Gelander, Anton Holmgren, Andreas F. M. Nierop
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pubertal growth Personalized growth Biological age SDS Weight status Longitudinal BMI-selection; reference population Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/f43fcb300ac846a39d376b99b5382f6d
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spelling	oai:doaj.org-article:f43fcb300ac846a39d376b99b5382f6d2021-11-14T12:33:19ZNovel type of references for weight aligned for onset of puberty – using the QEPS growth model10.1186/s12887-021-02954-z1471-2431https://doaj.org/article/f43fcb300ac846a39d376b99b5382f6d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-02954-zhttps://doaj.org/toc/1471-2431Abstract Background Growth references are traditionally constructed relative to chronological age, despite inter-individual variations in pubertal timing. A new type of height reference was recently developed allowing growth to be aligned based on onset of pubertal height growth. We here aim to develop a corresponding reference for pubertal weight. Methods To model QEPS-weight, 3595 subjects (1779 girls) from GrowUp1974Gothenburg and GrowUp1990Gothenburg were used. The QEPS-height-model was transformed to a corresponding QEPS-weight-model; thereafter, QEPS-weight was modified by an individual, constitutional weight-height-factor. Longitudinal weight and length/height measurements from 1418 individuals (698 girls) from GrowUp1990Gothenburg were then used to create weight references aligned for height at pubertal onset (the age at 5% of P-function growth, AgeP5). GrowUp1974Gothenburg subgroups based on pubertal timing, stature at pubertal onset, and childhood body composition were assessed using the references. Results References (median, SDS) for total weight (QEPS-functions), weight specific to puberty (P-function), and weight gain in the absence of specific pubertal growth (basic weight, QES-functions), allowing alignment of individual growth based on age at pubertal onset. For both sexes, basic weight was greater than average for late maturing, tall and high-BMI subgroups. The P-function-related weight was greater than average in short and lower than average in tall children, in those with high BMI, and in girls but not boys with low BMI. Conclusions New pubertal weight references allow individual variations in pubertal timing to be taken into consideration when evaluating growth. When used together with the comparable pubertal height reference, this will improve growth monitoring in clinical practice for identifying abnormal growth and serve as a valuable research tool providing insight into human growth.Kerstin Albertsson-WiklandAimon NiklassonLars GelanderAnton HolmgrenAndreas F. M. NieropBMCarticlePubertal growthPersonalized growthBiological ageSDSWeight statusLongitudinal BMI-selection; reference populationPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pubertal growth Personalized growth Biological age SDS Weight status Longitudinal BMI-selection; reference population Pediatrics RJ1-570
spellingShingle	Pubertal growth Personalized growth Biological age SDS Weight status Longitudinal BMI-selection; reference population Pediatrics RJ1-570 Kerstin Albertsson-Wikland Aimon Niklasson Lars Gelander Anton Holmgren Andreas F. M. Nierop Novel type of references for weight aligned for onset of puberty – using the QEPS growth model
description	Abstract Background Growth references are traditionally constructed relative to chronological age, despite inter-individual variations in pubertal timing. A new type of height reference was recently developed allowing growth to be aligned based on onset of pubertal height growth. We here aim to develop a corresponding reference for pubertal weight. Methods To model QEPS-weight, 3595 subjects (1779 girls) from GrowUp1974Gothenburg and GrowUp1990Gothenburg were used. The QEPS-height-model was transformed to a corresponding QEPS-weight-model; thereafter, QEPS-weight was modified by an individual, constitutional weight-height-factor. Longitudinal weight and length/height measurements from 1418 individuals (698 girls) from GrowUp1990Gothenburg were then used to create weight references aligned for height at pubertal onset (the age at 5% of P-function growth, AgeP5). GrowUp1974Gothenburg subgroups based on pubertal timing, stature at pubertal onset, and childhood body composition were assessed using the references. Results References (median, SDS) for total weight (QEPS-functions), weight specific to puberty (P-function), and weight gain in the absence of specific pubertal growth (basic weight, QES-functions), allowing alignment of individual growth based on age at pubertal onset. For both sexes, basic weight was greater than average for late maturing, tall and high-BMI subgroups. The P-function-related weight was greater than average in short and lower than average in tall children, in those with high BMI, and in girls but not boys with low BMI. Conclusions New pubertal weight references allow individual variations in pubertal timing to be taken into consideration when evaluating growth. When used together with the comparable pubertal height reference, this will improve growth monitoring in clinical practice for identifying abnormal growth and serve as a valuable research tool providing insight into human growth.
format	article
author	Kerstin Albertsson-Wikland Aimon Niklasson Lars Gelander Anton Holmgren Andreas F. M. Nierop
author_facet	Kerstin Albertsson-Wikland Aimon Niklasson Lars Gelander Anton Holmgren Andreas F. M. Nierop
author_sort	Kerstin Albertsson-Wikland
title	Novel type of references for weight aligned for onset of puberty – using the QEPS growth model
title_short	Novel type of references for weight aligned for onset of puberty – using the QEPS growth model
title_full	Novel type of references for weight aligned for onset of puberty – using the QEPS growth model
title_fullStr	Novel type of references for weight aligned for onset of puberty – using the QEPS growth model
title_full_unstemmed	Novel type of references for weight aligned for onset of puberty – using the QEPS growth model
title_sort	novel type of references for weight aligned for onset of puberty – using the qeps growth model
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f43fcb300ac846a39d376b99b5382f6d
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Novel type of references for weight aligned for onset of puberty – using the QEPS growth model

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