Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis

Abstract Background The hygiene hypothesis posits that microbial exposure reduces risk of asthma and other respiratory-related diseases. Helicobacter pylori and hepatitis A virus (HAV) are common fecal–oral infections. Our study aimed to examine associations of seropositivity to these agents with as...

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Autores principales:	Christian S. Alvarez, M. Larissa Avilés-Santa, Neal D. Freedman, Krista M. Perreira, Olga Garcia-Bedoya, Robert C. Kaplan, Martha L. Daviglus, Barry I. Graubard, Gregory A. Talavera, Bharat Thyagarajan, M. Constanza Camargo
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Asthma Helicobacter pylori Hepatitis A virus Mexicans Puerto Ricans Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f44054eb032542d99a713c2567f0846e
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spelling	oai:doaj.org-article:f44054eb032542d99a713c2567f0846e2021-11-28T12:36:15ZAssociations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis10.1186/s13223-021-00625-31710-1492https://doaj.org/article/f44054eb032542d99a713c2567f0846e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13223-021-00625-3https://doaj.org/toc/1710-1492Abstract Background The hygiene hypothesis posits that microbial exposure reduces risk of asthma and other respiratory-related diseases. Helicobacter pylori and hepatitis A virus (HAV) are common fecal–oral infections. Our study aimed to examine associations of seropositivity to these agents with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Methods A total of 12,471 HCHS/SOL participants with baseline data on self-reported physician-diagnosed asthma, and antibodies anti-H. pylori and anti-HAV were included in this cross-sectional analysis. Multivariable logistic regression models were used to estimate the odds ratios and 95% confidence intervals for the overall associations of seropositivity to each agent with asthma. Analyses were also stratified by Hispanic/Latino background. Effect modification by smoking status and nativity were tested. An analysis restricted to individuals with spirometry-defined chronic obstructive pulmonary disease (COPD) was also considered. Results The weighted overall prevalence of asthma was 16.6%. The weighted seroprevalence of H. pylori was 56.6% and of HAV was 76.6%, and they significantly differed by Hispanic/Latino background. After accounting for age, sex, education and other key confounders, we found no associations between H. pylori or HAV seropositivity with asthma (with and without COPD), either for all individuals combined or for any of the six specific backgrounds. There were no significant interactions by smoking and nativity. Conclusion Our findings did not provide support for the role of H. pylori or HAV, as evidence of the hygiene hypothesis in asthma among the large and diverse Hispanic/Latino populations of the HCHS/SOL. Trial registration NCT02060344Christian S. AlvarezM. Larissa Avilés-SantaNeal D. FreedmanKrista M. PerreiraOlga Garcia-BedoyaRobert C. KaplanMartha L. DaviglusBarry I. GraubardGregory A. TalaveraBharat ThyagarajanM. Constanza CamargoBMCarticleAsthmaHelicobacter pyloriHepatitis A virusMexicansPuerto RicansImmunologic diseases. AllergyRC581-607ENAllergy, Asthma & Clinical Immunology, Vol 17, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asthma Helicobacter pylori Hepatitis A virus Mexicans Puerto Ricans Immunologic diseases. Allergy RC581-607
spellingShingle	Asthma Helicobacter pylori Hepatitis A virus Mexicans Puerto Ricans Immunologic diseases. Allergy RC581-607 Christian S. Alvarez M. Larissa Avilés-Santa Neal D. Freedman Krista M. Perreira Olga Garcia-Bedoya Robert C. Kaplan Martha L. Daviglus Barry I. Graubard Gregory A. Talavera Bharat Thyagarajan M. Constanza Camargo Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis
description	Abstract Background The hygiene hypothesis posits that microbial exposure reduces risk of asthma and other respiratory-related diseases. Helicobacter pylori and hepatitis A virus (HAV) are common fecal–oral infections. Our study aimed to examine associations of seropositivity to these agents with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Methods A total of 12,471 HCHS/SOL participants with baseline data on self-reported physician-diagnosed asthma, and antibodies anti-H. pylori and anti-HAV were included in this cross-sectional analysis. Multivariable logistic regression models were used to estimate the odds ratios and 95% confidence intervals for the overall associations of seropositivity to each agent with asthma. Analyses were also stratified by Hispanic/Latino background. Effect modification by smoking status and nativity were tested. An analysis restricted to individuals with spirometry-defined chronic obstructive pulmonary disease (COPD) was also considered. Results The weighted overall prevalence of asthma was 16.6%. The weighted seroprevalence of H. pylori was 56.6% and of HAV was 76.6%, and they significantly differed by Hispanic/Latino background. After accounting for age, sex, education and other key confounders, we found no associations between H. pylori or HAV seropositivity with asthma (with and without COPD), either for all individuals combined or for any of the six specific backgrounds. There were no significant interactions by smoking and nativity. Conclusion Our findings did not provide support for the role of H. pylori or HAV, as evidence of the hygiene hypothesis in asthma among the large and diverse Hispanic/Latino populations of the HCHS/SOL. Trial registration NCT02060344
format	article
author	Christian S. Alvarez M. Larissa Avilés-Santa Neal D. Freedman Krista M. Perreira Olga Garcia-Bedoya Robert C. Kaplan Martha L. Daviglus Barry I. Graubard Gregory A. Talavera Bharat Thyagarajan M. Constanza Camargo
author_facet	Christian S. Alvarez M. Larissa Avilés-Santa Neal D. Freedman Krista M. Perreira Olga Garcia-Bedoya Robert C. Kaplan Martha L. Daviglus Barry I. Graubard Gregory A. Talavera Bharat Thyagarajan M. Constanza Camargo
author_sort	Christian S. Alvarez
title	Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis
title_short	Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis
title_full	Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis
title_fullStr	Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis
title_full_unstemmed	Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis
title_sort	associations of helicobacter pylori and hepatitis a seropositivity with asthma in the hispanic community health study/study of latinos (hchs/sol): addressing the hygiene hypothesis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f44054eb032542d99a713c2567f0846e
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Associations of Helicobacter pylori and hepatitis A seropositivity with asthma in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): addressing the hygiene hypothesis

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