Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis

Bacillus thuringiensis Vip3 (Vegetative Insecticidal Protein 3) toxins are widely used in biotech crops to control Lepidopteran pests. Here authors present the cryo-EM structures of the protoxin and the protease-activated state of Vip3Aa which shed light on the molecular basis for Vip3 activation.

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Autores principales:	Rafael Núñez-Ramírez, Juanjo Huesa, Yolanda Bel, Juan Ferré, Patricia Casino, Ernesto Arias-Palomo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f4448b8a86204737aec24834ae368c1f
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spelling	oai:doaj.org-article:f4448b8a86204737aec24834ae368c1f2021-12-02T14:53:51ZMolecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis10.1038/s41467-020-17758-52041-1723https://doaj.org/article/f4448b8a86204737aec24834ae368c1f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17758-5https://doaj.org/toc/2041-1723Bacillus thuringiensis Vip3 (Vegetative Insecticidal Protein 3) toxins are widely used in biotech crops to control Lepidopteran pests. Here authors present the cryo-EM structures of the protoxin and the protease-activated state of Vip3Aa which shed light on the molecular basis for Vip3 activation.Rafael Núñez-RamírezJuanjo HuesaYolanda BelJuan FerréPatricia CasinoErnesto Arias-PalomoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rafael Núñez-Ramírez Juanjo Huesa Yolanda Bel Juan Ferré Patricia Casino Ernesto Arias-Palomo Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis
description	Bacillus thuringiensis Vip3 (Vegetative Insecticidal Protein 3) toxins are widely used in biotech crops to control Lepidopteran pests. Here authors present the cryo-EM structures of the protoxin and the protease-activated state of Vip3Aa which shed light on the molecular basis for Vip3 activation.
format	article
author	Rafael Núñez-Ramírez Juanjo Huesa Yolanda Bel Juan Ferré Patricia Casino Ernesto Arias-Palomo
author_facet	Rafael Núñez-Ramírez Juanjo Huesa Yolanda Bel Juan Ferré Patricia Casino Ernesto Arias-Palomo
author_sort	Rafael Núñez-Ramírez
title	Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis
title_short	Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis
title_full	Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis
title_fullStr	Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis
title_full_unstemmed	Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis
title_sort	molecular architecture and activation of the insecticidal protein vip3aa from bacillus thuringiensis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f4448b8a86204737aec24834ae368c1f
work_keys_str_mv	AT rafaelnunezramirez moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT juanjohuesa moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT yolandabel moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT juanferre moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT patriciacasino moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis AT ernestoariaspalomo moleculararchitectureandactivationoftheinsecticidalproteinvip3aafrombacillusthuringiensis
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Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis

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