Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes
Netrins are secreted guidance factors that promote axon outgrowth and orientation during nervous system development. Here the authors present structural and biological evidence that netrin-4 is not a guidance cue per se, but rather functions to modulate laminin-laminin interactions.
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Nature Portfolio
2016
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oai:doaj.org-article:f4475045ce9e4ba1bd5baacc45fc74b92021-12-02T15:34:53ZStructural decoding of netrin-4 reveals a regulatory function towards mature basement membranes10.1038/ncomms135152041-1723https://doaj.org/article/f4475045ce9e4ba1bd5baacc45fc74b92016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13515https://doaj.org/toc/2041-1723Netrins are secreted guidance factors that promote axon outgrowth and orientation during nervous system development. Here the authors present structural and biological evidence that netrin-4 is not a guidance cue per se, but rather functions to modulate laminin-laminin interactions.Raphael ReutenTrushar R. PatelMatthew McDougallNicolas RamaDenise NikodemusBenjamin GibertJean-Guy DelcrosCarina PreinMarkus MeierStéphanie MetzgerZhigang ZhouJennifer KaltenbergKaren K. McKeeTobias BaldThomas TütingPaola ZigrinoValentin DjonovWilhelm BlochHauke Clausen-SchaumannErnst PoschlPeter D. YurchencoMartin EhrbarPatrick MehlenJörg StetefeldManuel KochNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Raphael Reuten Trushar R. Patel Matthew McDougall Nicolas Rama Denise Nikodemus Benjamin Gibert Jean-Guy Delcros Carina Prein Markus Meier Stéphanie Metzger Zhigang Zhou Jennifer Kaltenberg Karen K. McKee Tobias Bald Thomas Tüting Paola Zigrino Valentin Djonov Wilhelm Bloch Hauke Clausen-Schaumann Ernst Poschl Peter D. Yurchenco Martin Ehrbar Patrick Mehlen Jörg Stetefeld Manuel Koch Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes |
| description |
Netrins are secreted guidance factors that promote axon outgrowth and orientation during nervous system development. Here the authors present structural and biological evidence that netrin-4 is not a guidance cue per se, but rather functions to modulate laminin-laminin interactions. |
| format |
article |
| author |
Raphael Reuten Trushar R. Patel Matthew McDougall Nicolas Rama Denise Nikodemus Benjamin Gibert Jean-Guy Delcros Carina Prein Markus Meier Stéphanie Metzger Zhigang Zhou Jennifer Kaltenberg Karen K. McKee Tobias Bald Thomas Tüting Paola Zigrino Valentin Djonov Wilhelm Bloch Hauke Clausen-Schaumann Ernst Poschl Peter D. Yurchenco Martin Ehrbar Patrick Mehlen Jörg Stetefeld Manuel Koch |
| author_facet |
Raphael Reuten Trushar R. Patel Matthew McDougall Nicolas Rama Denise Nikodemus Benjamin Gibert Jean-Guy Delcros Carina Prein Markus Meier Stéphanie Metzger Zhigang Zhou Jennifer Kaltenberg Karen K. McKee Tobias Bald Thomas Tüting Paola Zigrino Valentin Djonov Wilhelm Bloch Hauke Clausen-Schaumann Ernst Poschl Peter D. Yurchenco Martin Ehrbar Patrick Mehlen Jörg Stetefeld Manuel Koch |
| author_sort |
Raphael Reuten |
| title |
Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes |
| title_short |
Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes |
| title_full |
Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes |
| title_fullStr |
Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes |
| title_full_unstemmed |
Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes |
| title_sort |
structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/f4475045ce9e4ba1bd5baacc45fc74b9 |
| work_keys_str_mv |
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| _version_ |
1718386754568847360 |