The cell wall-associated mycolactone polyketide synthases are necessary but not sufficient for mycolactone biosynthesis.
Mycolactones are polyketide-derived lipid virulence factors made by the slow-growing human pathogen, Mycobacterium ulcerans. Three unusually large and homologous plasmid-borne genes (mlsA1: 51 kb, mlsB: 42 kb and mlsA2: 7 kb) encode the mycolactone type I polyketide synthases (PKS). The extreme size...
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Autores principales: | Jessica L Porter, Nicholas J Tobias, Sacha J Pidot, Steffen Falgner, Kellie L Tuck, Andrea Vettiger, Hui Hong, Peter F Leadlay, Timothy P Stinear |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2013
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Materias: | |
Acceso en línea: | https://doaj.org/article/f4488c8b8faa4147bb82d834045ccc60 |
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