Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD

Abstract Structural neuroimaging studies of posttraumatic stress disorder (PTSD) have typically reported reduced cortical thickness (CT) and gray matter volume (GMV) in subcortical structures and networks involved in memory retrieval, emotional processing and regulation, and fear acquisition and ext...

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Autores principales:	Kevin M. Crombie, Marisa C. Ross, Allison M. Letkiewicz, Anneliis Sartin-Tarm, Josh M. Cisler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f448ace764c84151bc484cb6f3da65ea
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spelling	oai:doaj.org-article:f448ace764c84151bc484cb6f3da65ea2021-12-02T10:49:22ZDifferential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD10.1038/s41598-020-80776-22045-2322https://doaj.org/article/f448ace764c84151bc484cb6f3da65ea2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80776-2https://doaj.org/toc/2045-2322Abstract Structural neuroimaging studies of posttraumatic stress disorder (PTSD) have typically reported reduced cortical thickness (CT) and gray matter volume (GMV) in subcortical structures and networks involved in memory retrieval, emotional processing and regulation, and fear acquisition and extinction. Although PTSD is more common in women, and interpersonal violence (IPV) exposure is a more potent risk factor for developing PTSD relative to other forms of trauma, most of the existing literature examined combat-exposed men with PTSD. Vertex-wise CT and subcortical GMV analyses were conducted to examine potential differences in a large, well-characterized sample of women with PTSD stemming from IPV-exposure (n = 99) compared to healthy trauma-free women without a diagnosis of PTSD (n = 22). Subgroup analyses were also conducted to determine whether symptom severity within specific PTSD symptom clusters (e.g., re-experiencing, active avoidance, hyperarousal) predict CT and GMV after controlling for comorbid depression and anxiety. Results indicated that a diagnosis of PTSD in women with IPV-exposure did not significantly predict differences in CT across the cortex or GMV in the amygdala or hippocampus compared to healthy controls. However, within the PTSD group, greater re-experiencing symptom severity was associated with decreased CT in the left inferior and middle temporal gyrus, and decreased CT in the right parahippocampal and medial temporal gyrus. In contrast, greater active avoidance symptom severity was associated with greater CT in the left lateral fissure, postcentral gyrus, and middle/lateral occipital cortex, and greater CT in the right paracentral, posterior cingulate, and superior occipital gyrus. In terms of GMV, greater hyperarousal symptom severity was associated with reduced left amygdala GMV, while greater active avoidance symptom severity was associated with greater right amygdala GMV. These findings suggest that structural brain alterations among women with IPV-related PTSD may be driven by symptom severity within specific symptom clusters and that PTSD symptom clusters may have a differential (increased or decreased) association with brain structures.Kevin M. CrombieMarisa C. RossAllison M. LetkiewiczAnneliis Sartin-TarmJosh M. CislerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kevin M. Crombie Marisa C. Ross Allison M. Letkiewicz Anneliis Sartin-Tarm Josh M. Cisler Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD
description	Abstract Structural neuroimaging studies of posttraumatic stress disorder (PTSD) have typically reported reduced cortical thickness (CT) and gray matter volume (GMV) in subcortical structures and networks involved in memory retrieval, emotional processing and regulation, and fear acquisition and extinction. Although PTSD is more common in women, and interpersonal violence (IPV) exposure is a more potent risk factor for developing PTSD relative to other forms of trauma, most of the existing literature examined combat-exposed men with PTSD. Vertex-wise CT and subcortical GMV analyses were conducted to examine potential differences in a large, well-characterized sample of women with PTSD stemming from IPV-exposure (n = 99) compared to healthy trauma-free women without a diagnosis of PTSD (n = 22). Subgroup analyses were also conducted to determine whether symptom severity within specific PTSD symptom clusters (e.g., re-experiencing, active avoidance, hyperarousal) predict CT and GMV after controlling for comorbid depression and anxiety. Results indicated that a diagnosis of PTSD in women with IPV-exposure did not significantly predict differences in CT across the cortex or GMV in the amygdala or hippocampus compared to healthy controls. However, within the PTSD group, greater re-experiencing symptom severity was associated with decreased CT in the left inferior and middle temporal gyrus, and decreased CT in the right parahippocampal and medial temporal gyrus. In contrast, greater active avoidance symptom severity was associated with greater CT in the left lateral fissure, postcentral gyrus, and middle/lateral occipital cortex, and greater CT in the right paracentral, posterior cingulate, and superior occipital gyrus. In terms of GMV, greater hyperarousal symptom severity was associated with reduced left amygdala GMV, while greater active avoidance symptom severity was associated with greater right amygdala GMV. These findings suggest that structural brain alterations among women with IPV-related PTSD may be driven by symptom severity within specific symptom clusters and that PTSD symptom clusters may have a differential (increased or decreased) association with brain structures.
format	article
author	Kevin M. Crombie Marisa C. Ross Allison M. Letkiewicz Anneliis Sartin-Tarm Josh M. Cisler
author_facet	Kevin M. Crombie Marisa C. Ross Allison M. Letkiewicz Anneliis Sartin-Tarm Josh M. Cisler
author_sort	Kevin M. Crombie
title	Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD
title_short	Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD
title_full	Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD
title_fullStr	Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD
title_full_unstemmed	Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD
title_sort	differential relationships of ptsd symptom clusters with cortical thickness and grey matter volumes among women with ptsd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f448ace764c84151bc484cb6f3da65ea
work_keys_str_mv	AT kevinmcrombie differentialrelationshipsofptsdsymptomclusterswithcorticalthicknessandgreymattervolumesamongwomenwithptsd AT marisacross differentialrelationshipsofptsdsymptomclusterswithcorticalthicknessandgreymattervolumesamongwomenwithptsd AT allisonmletkiewicz differentialrelationshipsofptsdsymptomclusterswithcorticalthicknessandgreymattervolumesamongwomenwithptsd AT anneliissartintarm differentialrelationshipsofptsdsymptomclusterswithcorticalthicknessandgreymattervolumesamongwomenwithptsd AT joshmcisler differentialrelationshipsofptsdsymptomclusterswithcorticalthicknessandgreymattervolumesamongwomenwithptsd
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Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD

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