Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease

Objective. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients w...

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Autores principales: Wunsch Camile, Dornelles Thais Fernanda, Girardi Pricila, Arndt Marcelo Emilio, Genro Julia Pasqualini, Contini Veronica
Formato: article
Lenguaje:EN
Publicado: Sciendo 2019
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Acceso en línea:https://doaj.org/article/f449a173848c4c138c07c5f4c57e5e69
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spelling oai:doaj.org-article:f449a173848c4c138c07c5f4c57e5e692021-12-02T17:49:32ZLack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease1336-032910.2478/enr-2019-0001https://doaj.org/article/f449a173848c4c138c07c5f4c57e5e692019-01-01T00:00:00Zhttps://doi.org/10.2478/enr-2019-0001https://doaj.org/toc/1336-0329Objective. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients with cardiovascular disease (CAD) risk.Wunsch CamileDornelles Thais FernandaGirardi PricilaArndt Marcelo EmilioGenro Julia PasqualiniContini VeronicaSciendoarticlecoronary artery diseaserisk scoret2dmcadassociation studyDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 53, Iss 1, Pp 1-7 (2019)
institution DOAJ
collection DOAJ
language EN
topic coronary artery disease
risk score
t2dm
cad
association study
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
spellingShingle coronary artery disease
risk score
t2dm
cad
association study
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Wunsch Camile
Dornelles Thais Fernanda
Girardi Pricila
Arndt Marcelo Emilio
Genro Julia Pasqualini
Contini Veronica
Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
description Objective. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients with cardiovascular disease (CAD) risk.
format article
author Wunsch Camile
Dornelles Thais Fernanda
Girardi Pricila
Arndt Marcelo Emilio
Genro Julia Pasqualini
Contini Veronica
author_facet Wunsch Camile
Dornelles Thais Fernanda
Girardi Pricila
Arndt Marcelo Emilio
Genro Julia Pasqualini
Contini Veronica
author_sort Wunsch Camile
title Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_short Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_full Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_fullStr Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_full_unstemmed Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
title_sort lack of association between tcf7l2 gene variants and type 2 diabetes mellitus in a brazilian sample of patients with the risk for cardiovascular disease
publisher Sciendo
publishDate 2019
url https://doaj.org/article/f449a173848c4c138c07c5f4c57e5e69
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AT dornellesthaisfernanda lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
AT girardipricila lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
AT arndtmarceloemilio lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
AT genrojuliapasqualini lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
AT continiveronica lackofassociationbetweentcf7l2genevariantsandtype2diabetesmellitusinabraziliansampleofpatientswiththeriskforcardiovasculardisease
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