Robust phenotype prediction from gene expression data using differential shrinkage of co-regulated genes

Abstract Discovery of robust diagnostic or prognostic biomarkers is a key to optimizing therapeutic benefit for select patient cohorts - an idea commonly referred to as precision medicine. Most discovery studies to derive such markers from high-dimensional transcriptomics datasets are weakly powered...

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Bibliographic Details
Main Authors: Kourosh Zarringhalam, David Degras, Christoph Brockel, Daniel Ziemek
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/f44a5a3539404d7d921e917d3bb63b7d
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