ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I> (ANNONACEAE)
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Universidad de Antioquia
2009
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antiplasmodial activity Annonaceae colombian plants and aporphine alkaloids. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 |
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antiplasmodial activity Annonaceae colombian plants and aporphine alkaloids. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Edison J. OSORIO D. Guillermo L. MONTOYA P. Katalina MUÑOZ D. Gabriel J. ARANGO A. ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I> (ANNONACEAE) |
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antiparasitic effects from Anonaceae colombian plants, substantial antiplasmodial activity was observed
from the ethyl acetate extract of the stem of Rollinia pittieri and Pseudomalmea boyacana (Annonaceae),
the alkaloids isolated from these were studied. Of the alkaloids, liriodenine exhibited the highest activity
against chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum (CI50 = 8.0-10.0 μg/ml). In addition, inhibition of β-hematin formation (If????-h) by isolated compounds was evaluated
(Ifs-h). O-methylmoschatoline and melosmine showed inhibition percentage >96% at 2 mg/ml. Some
degree of cytotoxic to U-937 cells activity was observed by oxoporphine alkaloids.
|
| format |
article |
| author |
Edison J. OSORIO D. Guillermo L. MONTOYA P. Katalina MUÑOZ D. Gabriel J. ARANGO A. |
| author_facet |
Edison J. OSORIO D. Guillermo L. MONTOYA P. Katalina MUÑOZ D. Gabriel J. ARANGO A. |
| author_sort |
Edison J. OSORIO D. |
| title |
ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I> (ANNONACEAE) |
| title_short |
ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I> (ANNONACEAE) |
| title_full |
ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I> (ANNONACEAE) |
| title_fullStr |
ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I> (ANNONACEAE) |
| title_full_unstemmed |
ANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I> (ANNONACEAE) |
| title_sort |
antiplasmodial activity of aporphine alkaloids from <i>rollinia pittieri</i> and <i>pseudomalmea boyacana</i> (annonaceae) |
| publisher |
Universidad de Antioquia |
| publishDate |
2009 |
| url |
https://doaj.org/article/f44acfe3a371413e8c9d3971af23c1c6 |
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AT edisonjosoriod antiplasmodialactivityofaporphinealkaloidsfromirolliniapittieriiandipseudomalmeaboyacanaiannonaceae AT guillermolmontoyap antiplasmodialactivityofaporphinealkaloidsfromirolliniapittieriiandipseudomalmeaboyacanaiannonaceae AT katalinamunozd antiplasmodialactivityofaporphinealkaloidsfromirolliniapittieriiandipseudomalmeaboyacanaiannonaceae AT gabrieljarangoa antiplasmodialactivityofaporphinealkaloidsfromirolliniapittieriiandipseudomalmeaboyacanaiannonaceae |
| _version_ |
1718420446684119040 |
| spelling |
oai:doaj.org-article:f44acfe3a371413e8c9d3971af23c1c62021-11-19T04:22:30ZANTIPLASMODIAL ACTIVITY OF APORPHINE ALKALOIDS FROM <I>Rollinia pittieri</I> AND <I>Pseudomalmea boyacana</I> (ANNONACEAE)0121-40042145-2660https://doaj.org/article/f44acfe3a371413e8c9d3971af23c1c62009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/525https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 <!-- /* Font Definitions */ @font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-1610611985 1107304683 0 0 159 0;} @font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4; mso-font-charset:0; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-1610611985 1073750139 0 0 159 0;} @font-face {font-family:Aldine401BT-RomanA; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-alt:"MS Mincho"; mso-font-charset:128; mso-generic-font-family:auto; mso-font-format:other; mso-font-pitch:auto; mso-font-signature:3 134676480 16 0 131073 0;} @font-face {font-family:Verdana; panose-1:2 11 6 4 3 5 4 4 2 4; mso-font-charset:0; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:536871559 0 0 0 415 0;} @font-face {font-family:"\@Aldine401BT-RomanA"; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-charset:128; mso-generic-font-family:auto; mso-font-format:other; mso-font-pitch:auto; mso-font-signature:0 134676480 16 0 131072 0;} @font-face {font-family:TimesNewRomanPS-ItalicMT; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-charset:0; mso-generic-font-family:auto; mso-font-format:other; mso-font-pitch:auto; mso-font-signature:3 0 0 0 1 0;} @font-face {font-family:SymbolMT; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-alt:"MS Mincho"; mso-font-charset:128; mso-generic-font-family:auto; mso-font-format:other; mso-font-pitch:auto; mso-font-signature:1 134676480 16 0 131072 0;} @font-face {font-family:"\@SymbolMT"; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-charset:128; mso-generic-font-family:auto; mso-font-format:other; mso-font-pitch:auto; mso-font-signature:0 134676480 16 0 131072 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-fareast-language:EN-US;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:Calibri; mso-fareast-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi; mso-fareast-language:EN-US;} @page Section1 {size:595.3pt 841.9pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:35.4pt; mso-footer-margin:35.4pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> In the course of from ethnobotanical or chemotaxonomical studies on biologically active substances with antiparasitic effects from Anonaceae colombian plants, substantial antiplasmodial activity was observed from the ethyl acetate extract of the stem of Rollinia pittieri and Pseudomalmea boyacana (Annonaceae), the alkaloids isolated from these were studied. Of the alkaloids, liriodenine exhibited the highest activity against chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum (CI50 = 8.0-10.0 μg/ml). In addition, inhibition of β-hematin formation (If????-h) by isolated compounds was evaluated (Ifs-h). O-methylmoschatoline and melosmine showed inhibition percentage >96% at 2 mg/ml. Some degree of cytotoxic to U-937 cells activity was observed by oxoporphine alkaloids. Edison J. OSORIO D.Guillermo L. MONTOYA P.Katalina MUÑOZ D.Gabriel J. ARANGO A.Universidad de Antioquiaarticleantiplasmodial activityAnnonaceaecolombian plants and aporphine alkaloids.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 13, Iss 1 (2009) |