Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism

Hongyang Fan,1,2,* Xiaojia Tang,2,3,* Yuxia Song,2,3,* Peipei Liu,1,2 Yingzhu Chen1,2 1Clinical Medical College, Yangzhou University, Yangzhou City, Jiangsu Province, People’s Republic of China; 2Department of Neurology, Northern Jiangsu Province Hospital, Yangzhou City, Jiangsu Province,...

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Autores principales:	Fan H, Tang X, Song Y, Liu P, Chen Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	novel coronavirus pneumonia 2019-ncov sars-cov-2 cerebral vascular disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f44c0c57091c4eea8e0c258d3d824bae
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spelling	oai:doaj.org-article:f44c0c57091c4eea8e0c258d3d824bae2021-12-02T09:26:05ZInfluence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism1178-2021https://doaj.org/article/f44c0c57091c4eea8e0c258d3d824bae2020-05-01T00:00:00Zhttps://www.dovepress.com/influence-of-covid-19-on-cerebrovascular-disease-and-its-possible-mech-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hongyang Fan,1,2,* Xiaojia Tang,2,3,* Yuxia Song,2,3,* Peipei Liu,1,2 Yingzhu Chen1,2 1Clinical Medical College, Yangzhou University, Yangzhou City, Jiangsu Province, People’s Republic of China; 2Department of Neurology, Northern Jiangsu Province Hospital, Yangzhou City, Jiangsu Province, People’s Republic of China; 3Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou City, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingzhu Chen; Peipei Liu Email yzchendr@163.com; doclpp87@163.comAbstract: The global spread of COVID-19 has caused a substantial societal burden and become a major global public health issue. The COVID-19 elderly population with hypertension, diabetes, cardiovascular, and cerebrovascular diseases are at risk. Mortality rates are highest in these individuals if infected with COVID-19. Although the lungs are the main organs involved in acute respiratory distress syndrome caused by COVID-19 infection, COVID-19 triggers inflammatory and immune mechanisms, inducing a “cytokine storm” that aggravates disease progression and may lead to death. Presently, effective drugs are lacking, although current studies have confirmed that drugs with therapeutic potential include redaciclovir, lopinavir/ritonavir combined with interferon-β, convalescent plasma, and monoclonal antibodies. Currently, the most reasonable and effective way to prevent COVID-19 is to control the source of infection, terminate routes of transmission, and protect susceptible populations. With the rise of COVID-19 in China and worldwide, further prevention, diagnosis, and treatment measures are a critical unmet need. Cerebrovascular disease has high incidence, disability rate, and fatality rate. COVID-19 patient outcomes may also be complicated with acute stroke. This paper summarizes the influence of COVID-19 on cerebrovascular disease and discusses possible pathophysiological mechanisms to provide new angles for the prevention and diagnosis of this disease.Keywords: novel coronavirus pneumonia, 2019-nCoV, SARS-CoV-2, cerebral vascular diseaseFan HTang XSong YLiu PChen YDove Medical Pressarticlenovel coronavirus pneumonia2019-ncovsars-cov-2cerebral vascular diseaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1359-1367 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	novel coronavirus pneumonia 2019-ncov sars-cov-2 cerebral vascular disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	novel coronavirus pneumonia 2019-ncov sars-cov-2 cerebral vascular disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Fan H Tang X Song Y Liu P Chen Y Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism
description	Hongyang Fan,1,2,* Xiaojia Tang,2,3,* Yuxia Song,2,3,* Peipei Liu,1,2 Yingzhu Chen1,2 1Clinical Medical College, Yangzhou University, Yangzhou City, Jiangsu Province, People’s Republic of China; 2Department of Neurology, Northern Jiangsu Province Hospital, Yangzhou City, Jiangsu Province, People’s Republic of China; 3Department of Neurology, Clinical Medical College of Yangzhou, Dalian Medical University, Yangzhou City, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingzhu Chen; Peipei Liu Email yzchendr@163.com; doclpp87@163.comAbstract: The global spread of COVID-19 has caused a substantial societal burden and become a major global public health issue. The COVID-19 elderly population with hypertension, diabetes, cardiovascular, and cerebrovascular diseases are at risk. Mortality rates are highest in these individuals if infected with COVID-19. Although the lungs are the main organs involved in acute respiratory distress syndrome caused by COVID-19 infection, COVID-19 triggers inflammatory and immune mechanisms, inducing a “cytokine storm” that aggravates disease progression and may lead to death. Presently, effective drugs are lacking, although current studies have confirmed that drugs with therapeutic potential include redaciclovir, lopinavir/ritonavir combined with interferon-β, convalescent plasma, and monoclonal antibodies. Currently, the most reasonable and effective way to prevent COVID-19 is to control the source of infection, terminate routes of transmission, and protect susceptible populations. With the rise of COVID-19 in China and worldwide, further prevention, diagnosis, and treatment measures are a critical unmet need. Cerebrovascular disease has high incidence, disability rate, and fatality rate. COVID-19 patient outcomes may also be complicated with acute stroke. This paper summarizes the influence of COVID-19 on cerebrovascular disease and discusses possible pathophysiological mechanisms to provide new angles for the prevention and diagnosis of this disease.Keywords: novel coronavirus pneumonia, 2019-nCoV, SARS-CoV-2, cerebral vascular disease
format	article
author	Fan H Tang X Song Y Liu P Chen Y
author_facet	Fan H Tang X Song Y Liu P Chen Y
author_sort	Fan H
title	Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism
title_short	Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism
title_full	Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism
title_fullStr	Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism
title_full_unstemmed	Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism
title_sort	influence of covid-19 on cerebrovascular disease and its possible mechanism
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f44c0c57091c4eea8e0c258d3d824bae
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_version_	1718398159160344576

Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism

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