Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity

Alternative splicing coupled to nonsense-mediated decay (AS-NMD) is a conserved mechanism for post-transcriptional gene regulation. Here, the authors provide evidence that AS-NMD is enhanced during dietary restriction (DR) and is required for DR-mediated longevity assurance in C. elegans.

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Autores principales:	Syed Shamsh Tabrez, Ravi Datta Sharma, Vaibhav Jain, Atif Ahmed Siddiqui, Arnab Mukhopadhyay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f44c3f8b8fa7410ea1bd00d3f0cd9658
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spelling	oai:doaj.org-article:f44c3f8b8fa7410ea1bd00d3f0cd96582021-12-02T13:24:33ZDifferential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity10.1038/s41467-017-00370-52041-1723https://doaj.org/article/f44c3f8b8fa7410ea1bd00d3f0cd96582017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00370-5https://doaj.org/toc/2041-1723Alternative splicing coupled to nonsense-mediated decay (AS-NMD) is a conserved mechanism for post-transcriptional gene regulation. Here, the authors provide evidence that AS-NMD is enhanced during dietary restriction (DR) and is required for DR-mediated longevity assurance in C. elegans.Syed Shamsh TabrezRavi Datta SharmaVaibhav JainAtif Ahmed SiddiquiArnab MukhopadhyayNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Syed Shamsh Tabrez Ravi Datta Sharma Vaibhav Jain Atif Ahmed Siddiqui Arnab Mukhopadhyay Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity
description	Alternative splicing coupled to nonsense-mediated decay (AS-NMD) is a conserved mechanism for post-transcriptional gene regulation. Here, the authors provide evidence that AS-NMD is enhanced during dietary restriction (DR) and is required for DR-mediated longevity assurance in C. elegans.
format	article
author	Syed Shamsh Tabrez Ravi Datta Sharma Vaibhav Jain Atif Ahmed Siddiqui Arnab Mukhopadhyay
author_facet	Syed Shamsh Tabrez Ravi Datta Sharma Vaibhav Jain Atif Ahmed Siddiqui Arnab Mukhopadhyay
author_sort	Syed Shamsh Tabrez
title	Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity
title_short	Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity
title_full	Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity
title_fullStr	Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity
title_full_unstemmed	Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity
title_sort	differential alternative splicing coupled to nonsense-mediated decay of mrna ensures dietary restriction-induced longevity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f44c3f8b8fa7410ea1bd00d3f0cd9658
work_keys_str_mv	AT syedshamshtabrez differentialalternativesplicingcoupledtononsensemediateddecayofmrnaensuresdietaryrestrictioninducedlongevity AT ravidattasharma differentialalternativesplicingcoupledtononsensemediateddecayofmrnaensuresdietaryrestrictioninducedlongevity AT vaibhavjain differentialalternativesplicingcoupledtononsensemediateddecayofmrnaensuresdietaryrestrictioninducedlongevity AT atifahmedsiddiqui differentialalternativesplicingcoupledtononsensemediateddecayofmrnaensuresdietaryrestrictioninducedlongevity AT arnabmukhopadhyay differentialalternativesplicingcoupledtononsensemediateddecayofmrnaensuresdietaryrestrictioninducedlongevity
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Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity

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