Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

Collagen production by lung cells is critical to maintain organ architecture but can also drive pathological scarring. Here the authors perform single cell RNA sequencing of collagen-producing lung cells identifying a subset of pathologic fibroblasts characterized by Cthrc1 expression which are conc...

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Autores principales:	Tatsuya Tsukui, Kai-Hui Sun, Joseph B. Wetter, John R. Wilson-Kanamori, Lisa A. Hazelwood, Neil C. Henderson, Taylor S. Adams, Jonas C. Schupp, Sergio D. Poli, Ivan O. Rosas, Naftali Kaminski, Michael A. Matthay, Paul J. Wolters, Dean Sheppard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f45292590a314d048725872415c1b587
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spelling	oai:doaj.org-article:f45292590a314d048725872415c1b5872021-12-02T17:06:32ZCollagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis10.1038/s41467-020-15647-52041-1723https://doaj.org/article/f45292590a314d048725872415c1b5872020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15647-5https://doaj.org/toc/2041-1723Collagen production by lung cells is critical to maintain organ architecture but can also drive pathological scarring. Here the authors perform single cell RNA sequencing of collagen-producing lung cells identifying a subset of pathologic fibroblasts characterized by Cthrc1 expression which are concentrated within fibroblastic foci in fibrotic lungs and show a pro-fibrotic phenotype.Tatsuya TsukuiKai-Hui SunJoseph B. WetterJohn R. Wilson-KanamoriLisa A. HazelwoodNeil C. HendersonTaylor S. AdamsJonas C. SchuppSergio D. PoliIvan O. RosasNaftali KaminskiMichael A. MatthayPaul J. WoltersDean SheppardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tatsuya Tsukui Kai-Hui Sun Joseph B. Wetter John R. Wilson-Kanamori Lisa A. Hazelwood Neil C. Henderson Taylor S. Adams Jonas C. Schupp Sergio D. Poli Ivan O. Rosas Naftali Kaminski Michael A. Matthay Paul J. Wolters Dean Sheppard Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
description	Collagen production by lung cells is critical to maintain organ architecture but can also drive pathological scarring. Here the authors perform single cell RNA sequencing of collagen-producing lung cells identifying a subset of pathologic fibroblasts characterized by Cthrc1 expression which are concentrated within fibroblastic foci in fibrotic lungs and show a pro-fibrotic phenotype.
format	article
author	Tatsuya Tsukui Kai-Hui Sun Joseph B. Wetter John R. Wilson-Kanamori Lisa A. Hazelwood Neil C. Henderson Taylor S. Adams Jonas C. Schupp Sergio D. Poli Ivan O. Rosas Naftali Kaminski Michael A. Matthay Paul J. Wolters Dean Sheppard
author_facet	Tatsuya Tsukui Kai-Hui Sun Joseph B. Wetter John R. Wilson-Kanamori Lisa A. Hazelwood Neil C. Henderson Taylor S. Adams Jonas C. Schupp Sergio D. Poli Ivan O. Rosas Naftali Kaminski Michael A. Matthay Paul J. Wolters Dean Sheppard
author_sort	Tatsuya Tsukui
title	Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
title_short	Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
title_full	Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
title_fullStr	Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
title_full_unstemmed	Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
title_sort	collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f45292590a314d048725872415c1b587
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Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

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