PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment

Takehara et al performed imaging analysis of microcluster formation between the PD-L1 and PD-L2, which are known to play a role in T cell activation in response to tumour cell signaling. Their analysis showed that the cluster formation inhibited T cell receptor signaling and could serve as a visual...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tomohiro Takehara, Ei Wakamatsu, Hiroaki Machiyama, Wataru Nishi, Katsura Emoto, Miyuki Azuma, Kenzo Soejima, Koichi Fukunaga, Tadashi Yokosuka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f45334598a5740f7ad00ef5926a5af20
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f45334598a5740f7ad00ef5926a5af20
record_format	dspace
spelling	oai:doaj.org-article:f45334598a5740f7ad00ef5926a5af202021-12-02T15:43:08ZPD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment10.1038/s42003-021-02111-32399-3642https://doaj.org/article/f45334598a5740f7ad00ef5926a5af202021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02111-3https://doaj.org/toc/2399-3642Takehara et al performed imaging analysis of microcluster formation between the PD-L1 and PD-L2, which are known to play a role in T cell activation in response to tumour cell signaling. Their analysis showed that the cluster formation inhibited T cell receptor signaling and could serve as a visual index for PD-L1/2-targeted cancer therapies.Tomohiro TakeharaEi WakamatsuHiroaki MachiyamaWataru NishiKatsura EmotoMiyuki AzumaKenzo SoejimaKoichi FukunagaTadashi YokosukaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Tomohiro Takehara Ei Wakamatsu Hiroaki Machiyama Wataru Nishi Katsura Emoto Miyuki Azuma Kenzo Soejima Koichi Fukunaga Tadashi Yokosuka PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment
description	Takehara et al performed imaging analysis of microcluster formation between the PD-L1 and PD-L2, which are known to play a role in T cell activation in response to tumour cell signaling. Their analysis showed that the cluster formation inhibited T cell receptor signaling and could serve as a visual index for PD-L1/2-targeted cancer therapies.
format	article
author	Tomohiro Takehara Ei Wakamatsu Hiroaki Machiyama Wataru Nishi Katsura Emoto Miyuki Azuma Kenzo Soejima Koichi Fukunaga Tadashi Yokosuka
author_facet	Tomohiro Takehara Ei Wakamatsu Hiroaki Machiyama Wataru Nishi Katsura Emoto Miyuki Azuma Kenzo Soejima Koichi Fukunaga Tadashi Yokosuka
author_sort	Tomohiro Takehara
title	PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment
title_short	PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment
title_full	PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment
title_fullStr	PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment
title_full_unstemmed	PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment
title_sort	pd-l2 suppresses t cell signaling via coinhibitory microcluster formation and shp2 phosphatase recruitment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f45334598a5740f7ad00ef5926a5af20
work_keys_str_mv	AT tomohirotakehara pdl2suppressestcellsignalingviacoinhibitorymicroclusterformationandshp2phosphataserecruitment AT eiwakamatsu pdl2suppressestcellsignalingviacoinhibitorymicroclusterformationandshp2phosphataserecruitment AT hiroakimachiyama pdl2suppressestcellsignalingviacoinhibitorymicroclusterformationandshp2phosphataserecruitment AT watarunishi pdl2suppressestcellsignalingviacoinhibitorymicroclusterformationandshp2phosphataserecruitment AT katsuraemoto pdl2suppressestcellsignalingviacoinhibitorymicroclusterformationandshp2phosphataserecruitment AT miyukiazuma pdl2suppressestcellsignalingviacoinhibitorymicroclusterformationandshp2phosphataserecruitment AT kenzosoejima pdl2suppressestcellsignalingviacoinhibitorymicroclusterformationandshp2phosphataserecruitment AT koichifukunaga pdl2suppressestcellsignalingviacoinhibitorymicroclusterformationandshp2phosphataserecruitment AT tadashiyokosuka pdl2suppressestcellsignalingviacoinhibitorymicroclusterformationandshp2phosphataserecruitment
_version_	1718385846860644352

PD-L2 suppresses T cell signaling via coinhibitory microcluster formation and SHP2 phosphatase recruitment

Ejemplares similares