Histopathological Evaluation of Capsaicin on Cat Dental Pulp

BACKGROUND AND OBJECTIVE: Dental caries is the most common means of ingress of bacteria to the dental pulp and pulp infection. Different materials have been introduced for pulp therapy but they were not effective in producing an acceptable coronal seal. The aim of this study was to evaluate anti- in...

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Autores principales:	Z Madani, M Seyedmajidi, AA Moghadamnia, A Bijani, A Zahed Pasha
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	capsaicin pulp inflammation pulp dental barrier Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f4551c9207cd46579413d268ea9fe86e
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spelling	oai:doaj.org-article:f4551c9207cd46579413d268ea9fe86e2021-11-10T08:56:34ZHistopathological Evaluation of Capsaicin on Cat Dental Pulp1561-41072251-7170https://doaj.org/article/f4551c9207cd46579413d268ea9fe86e2011-05-01T00:00:00Zhttp://jbums.org/article-1-3797-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Dental caries is the most common means of ingress of bacteria to the dental pulp and pulp infection. Different materials have been introduced for pulp therapy but they were not effective in producing an acceptable coronal seal. The aim of this study was to evaluate anti- inflammatory effect of local capsaicin on dental pulp of cat.METHODS: Twenty–four canine teeth of six domestic short hair cats weighing approximately 3-4 kg were selected for this experimental study. After cats had been anesthetized, the crown of teeth were cut 3 mm upper than cementoenamel junction (CEJ) and exposed under sterile condition. The teeth were divided into two groups. In group I the exposed pulp was capped with zinc oxide–eugenol as control. In group II dental pulp capped with capsaicin as experimental group. All access cavities were sealed with glass ionomer cement (Fuji IX). The animals were sacrificed at 1, 2 and 4 weeks after procedure. The canine teeth were extracted for histopathologic evaluation. The specimens were sectioned serially at 6 µm thickness parallel to tooth long axis. The sections were stained with H & E and studied by light microscopy. FINDINGS: Result of this study showed that signs of necrosis in zinc oxide-eugenol group during 1, 2 and 4 weeks decreased significantly (p=0.026). In capsaicin group hyperemia during 1, 2 and 4 weeks decreased significantly (p=0.019). In comparison of the effect of two drugs on pulp in 4 weeks and all weeks the sign of necrosis in capsaicin group was increased significantly (p=0.029, p=0.039). Two groups showed difference in dental barrier formation, type of inflammatory responses and soft tissue changes but these differences were not statistically significant. CONCLUSION: According to findings of this study capsaicin could decrease the intensity of the inflammation but was not successful in dental barrier formation.Z MadaniM SeyedmajidiAA MoghadamniaA BijaniA Zahed PashaBabol University of Medical Sciencesarticlecapsaicinpulp inflammationpulpdental barrierMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 3, Pp 7-14 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	capsaicin pulp inflammation pulp dental barrier Medicine R Medicine (General) R5-920
spellingShingle	capsaicin pulp inflammation pulp dental barrier Medicine R Medicine (General) R5-920 Z Madani M Seyedmajidi AA Moghadamnia A Bijani A Zahed Pasha Histopathological Evaluation of Capsaicin on Cat Dental Pulp
description	BACKGROUND AND OBJECTIVE: Dental caries is the most common means of ingress of bacteria to the dental pulp and pulp infection. Different materials have been introduced for pulp therapy but they were not effective in producing an acceptable coronal seal. The aim of this study was to evaluate anti- inflammatory effect of local capsaicin on dental pulp of cat.METHODS: Twenty–four canine teeth of six domestic short hair cats weighing approximately 3-4 kg were selected for this experimental study. After cats had been anesthetized, the crown of teeth were cut 3 mm upper than cementoenamel junction (CEJ) and exposed under sterile condition. The teeth were divided into two groups. In group I the exposed pulp was capped with zinc oxide–eugenol as control. In group II dental pulp capped with capsaicin as experimental group. All access cavities were sealed with glass ionomer cement (Fuji IX). The animals were sacrificed at 1, 2 and 4 weeks after procedure. The canine teeth were extracted for histopathologic evaluation. The specimens were sectioned serially at 6 µm thickness parallel to tooth long axis. The sections were stained with H & E and studied by light microscopy. FINDINGS: Result of this study showed that signs of necrosis in zinc oxide-eugenol group during 1, 2 and 4 weeks decreased significantly (p=0.026). In capsaicin group hyperemia during 1, 2 and 4 weeks decreased significantly (p=0.019). In comparison of the effect of two drugs on pulp in 4 weeks and all weeks the sign of necrosis in capsaicin group was increased significantly (p=0.029, p=0.039). Two groups showed difference in dental barrier formation, type of inflammatory responses and soft tissue changes but these differences were not statistically significant. CONCLUSION: According to findings of this study capsaicin could decrease the intensity of the inflammation but was not successful in dental barrier formation.
format	article
author	Z Madani M Seyedmajidi AA Moghadamnia A Bijani A Zahed Pasha
author_facet	Z Madani M Seyedmajidi AA Moghadamnia A Bijani A Zahed Pasha
author_sort	Z Madani
title	Histopathological Evaluation of Capsaicin on Cat Dental Pulp
title_short	Histopathological Evaluation of Capsaicin on Cat Dental Pulp
title_full	Histopathological Evaluation of Capsaicin on Cat Dental Pulp
title_fullStr	Histopathological Evaluation of Capsaicin on Cat Dental Pulp
title_full_unstemmed	Histopathological Evaluation of Capsaicin on Cat Dental Pulp
title_sort	histopathological evaluation of capsaicin on cat dental pulp
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/f4551c9207cd46579413d268ea9fe86e
work_keys_str_mv	AT zmadani histopathologicalevaluationofcapsaicinoncatdentalpulp AT mseyedmajidi histopathologicalevaluationofcapsaicinoncatdentalpulp AT aamoghadamnia histopathologicalevaluationofcapsaicinoncatdentalpulp AT abijani histopathologicalevaluationofcapsaicinoncatdentalpulp AT azahedpasha histopathologicalevaluationofcapsaicinoncatdentalpulp
_version_	1718440339228852224

Histopathological Evaluation of Capsaicin on Cat Dental Pulp

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