Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury

Abstract Spinal cord injury (SCI) leads to reactive inflammation and other harmful events that limit spinal cord regeneration. We propose an approach for studying the mechanisms at the levels of network topology, gene ontology, signaling pathways, and disease inference. We treated inflammatory media...

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Autores principales:	Weiping Zhu, Xuning Chen, Le Ning, Kan Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f455917402e245d8a41cb8be0b179313
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spelling	oai:doaj.org-article:f455917402e245d8a41cb8be0b1793132021-12-02T15:08:46ZNetwork Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury10.1038/s41598-018-37357-12045-2322https://doaj.org/article/f455917402e245d8a41cb8be0b1793132019-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-37357-1https://doaj.org/toc/2045-2322Abstract Spinal cord injury (SCI) leads to reactive inflammation and other harmful events that limit spinal cord regeneration. We propose an approach for studying the mechanisms at the levels of network topology, gene ontology, signaling pathways, and disease inference. We treated inflammatory mediators as toxic chemicals and retrieved the genes and interacting proteins associated with them via a set of biological medical databases and software. We identified >10,000 genes associated with SCI. Tumor necrosis factor (TNF) had the highest scores, and the top 30 were adopted as core data. In the core interacting protein network, TNF and other top 10 nodes were the major hubs. The core members were involved in cellular responses and metabolic processes, as components of the extracellular space and regions, in protein-binding and receptor-binding functions, as well as in the TNF signaling pathway. In addition, both seizures and SCI were highly associated with TNF levels; therefore, for achieving a better curative effect on SCI, TNF and other major hubs should be targeted together according to the theory of network intervention, rather than a single target such as TNF alone. Furthermore, certain drugs used to treat epilepsy could be used to treat SCI as adjuvants.Weiping ZhuXuning ChenLe NingKan JinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weiping Zhu Xuning Chen Le Ning Kan Jin Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury
description	Abstract Spinal cord injury (SCI) leads to reactive inflammation and other harmful events that limit spinal cord regeneration. We propose an approach for studying the mechanisms at the levels of network topology, gene ontology, signaling pathways, and disease inference. We treated inflammatory mediators as toxic chemicals and retrieved the genes and interacting proteins associated with them via a set of biological medical databases and software. We identified >10,000 genes associated with SCI. Tumor necrosis factor (TNF) had the highest scores, and the top 30 were adopted as core data. In the core interacting protein network, TNF and other top 10 nodes were the major hubs. The core members were involved in cellular responses and metabolic processes, as components of the extracellular space and regions, in protein-binding and receptor-binding functions, as well as in the TNF signaling pathway. In addition, both seizures and SCI were highly associated with TNF levels; therefore, for achieving a better curative effect on SCI, TNF and other major hubs should be targeted together according to the theory of network intervention, rather than a single target such as TNF alone. Furthermore, certain drugs used to treat epilepsy could be used to treat SCI as adjuvants.
format	article
author	Weiping Zhu Xuning Chen Le Ning Kan Jin
author_facet	Weiping Zhu Xuning Chen Le Ning Kan Jin
author_sort	Weiping Zhu
title	Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury
title_short	Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury
title_full	Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury
title_fullStr	Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury
title_full_unstemmed	Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury
title_sort	network analysis reveals tnf as a major hub of reactive inflammation following spinal cord injury
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f455917402e245d8a41cb8be0b179313
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_version_	1718388036433084416

Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury

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