Fluorescent gold nanoclusters for efficient cancer cell targeting

Rahul Purohit, Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Well-known surface properties of gold nanoparticles (AuNPs) offer easy surface modification with desired biomolecule, thus enabling them to be used fo...

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Autores principales:	Purohit R, Singh S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Gold nanoclusters Fluorescent AuNCs Cancer cell imaging and targeting Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f45641907f1045099c87651624e622ce
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spelling	oai:doaj.org-article:f45641907f1045099c87651624e622ce2021-12-02T07:45:56ZFluorescent gold nanoclusters for efficient cancer cell targeting1178-2013https://doaj.org/article/f45641907f1045099c87651624e622ce2018-03-01T00:00:00Zhttps://www.dovepress.com/fluorescent-gold-nanoclusters-for-efficient-cancer-cell-targeting-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rahul Purohit, Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Well-known surface properties of gold nanoparticles (AuNPs) offer easy surface modification with desired biomolecule, thus enabling them to be used for targeting and imaging of cancer cells/tissues. However, targeting and imaging capability come through after synthesis coating of AuNPs’ surface with targeting or imaging molecules. Attempts have been made to conjugate both imaging and targeting molecules over the AuNPs, but have seen limited success. Hence, exploiting the fluorescence properties of gold nanoclusters (AuNCs), we have synthesized glucose-coated AuNCs for exhibiting both the imaging and targeting properties. These clusters have shown rapid and selective uptake in cancerous (A549) cells when compared with bovine serum albumin-coated AuNCs. Keywords: gold nanoclusters, fluorescent AuNCs, cancer cell imaging and targetingPurohit RSingh SDove Medical PressarticleGold nanoclustersFluorescent AuNCsCancer cell imaging and targetingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 15-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold nanoclusters Fluorescent AuNCs Cancer cell imaging and targeting Medicine (General) R5-920
spellingShingle	Gold nanoclusters Fluorescent AuNCs Cancer cell imaging and targeting Medicine (General) R5-920 Purohit R Singh S Fluorescent gold nanoclusters for efficient cancer cell targeting
description	Rahul Purohit, Sanjay Singh Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India Abstract: Well-known surface properties of gold nanoparticles (AuNPs) offer easy surface modification with desired biomolecule, thus enabling them to be used for targeting and imaging of cancer cells/tissues. However, targeting and imaging capability come through after synthesis coating of AuNPs’ surface with targeting or imaging molecules. Attempts have been made to conjugate both imaging and targeting molecules over the AuNPs, but have seen limited success. Hence, exploiting the fluorescence properties of gold nanoclusters (AuNCs), we have synthesized glucose-coated AuNCs for exhibiting both the imaging and targeting properties. These clusters have shown rapid and selective uptake in cancerous (A549) cells when compared with bovine serum albumin-coated AuNCs. Keywords: gold nanoclusters, fluorescent AuNCs, cancer cell imaging and targeting
format	article
author	Purohit R Singh S
author_facet	Purohit R Singh S
author_sort	Purohit R
title	Fluorescent gold nanoclusters for efficient cancer cell targeting
title_short	Fluorescent gold nanoclusters for efficient cancer cell targeting
title_full	Fluorescent gold nanoclusters for efficient cancer cell targeting
title_fullStr	Fluorescent gold nanoclusters for efficient cancer cell targeting
title_full_unstemmed	Fluorescent gold nanoclusters for efficient cancer cell targeting
title_sort	fluorescent gold nanoclusters for efficient cancer cell targeting
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f45641907f1045099c87651624e622ce
work_keys_str_mv	AT purohitr fluorescentgoldnanoclustersforefficientcancercelltargeting AT singhs fluorescentgoldnanoclustersforefficientcancercelltargeting
_version_	1718399195242561536

Fluorescent gold nanoclusters for efficient cancer cell targeting

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